Clinical and epidemiological characteristics and risk factors for mortality in patients with candidemia in hospitals from Bogotá, Colombia

Cortés, Jorge Alberto; Reyes, Patricia; Gómez, Carlos; Cuervo, Sonia Isabel; Rivas, Pilar Cebollero; Casas, Christian A.; Pedraza, Ricardo Sánchez

doi:10.1016/j.bjid.2014.06.009

Cited by 30 publications

(29 citation statements)

References 29 publications

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“…However, some studies suggested an association between high rates of mortality of CBSI and cultivation of biofilm-forming C. albicans and C. parapsilosis from the blood, which confirms that biofilm formation significantly affects the virulence of C. albicans or enhances pathogenic potential of C. parapsilosis [6]. Delays in the initiation of antifungal therapy, longer than 12-15 h after the identification of positive blood cultures, correlated with an increased risk of death [26]. The type of the administered antifungal therapy could also have a major impact on the outcome of CBSI.…”

Section: Discussionmentioning

confidence: 92%

Surveillance and characterization of Candida bloodstream infections in a Serbian tertiary care hospital

Stojanović

Stojanović-Radić

et al. 2016

J Infect Dev Ctries

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Introduction: Candida spp. frequently cause hospital-acquired bloodstream infections (BSI) with a high mortality rate (up to 70%). We analyzed the frequency, infection characteristics, potential predisposing factors, susceptibility to antifungal drugs, biofilm production and other virulence characteristics of Candida spp. isolates obtained from a tertiary care hospital in Niš, Serbia, during a one year period. Methods: Medical histories, characteristics of isolated strains and drug susceptibility, as well as the effect on the function of isolated macrophages and other virulence features were evaluated. The obtained results were subjected to student's t-test and multivariate statistical analyzes. Results: Herein we report an annual incidence of 3.65 cases of C. albicans, C. lusitaniae and C. lipolytica infections per 10 5 population. Out of eight isolated strains, two (25%) were shown to be strong biofilm producers, one (12.5%) caused hemolysis on blood agar and in two (25%) cases macrophages were able to completely eliminate the yeast colonies. Chronic kidney disease, diabetes, malignant and other diseases were present in 37.5, 62.5, 50 and 75%, respectively, in the study group. All patients with Candida BSI received antifungal therapy (amphotericin B), however, hospital mortality was observed in 25% of patients. Conclusions: Evaluation of local Candida epidemiology, antifungal susceptibility and virulence factors, as well as personalized patient risk factors are important for the surveillance of Candida BSI, especially in intensive care unit patients and may contribute to the improved options and outcome for patients with Candida BSI.

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Section: Discussionmentioning

confidence: 92%

Surveillance and characterization of Candida bloodstream infections in a Serbian tertiary care hospital

Stojanović

Stojanović-Radić

et al. 2016

J Infect Dev Ctries

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“…A significant trend towards an increased number of cases of candidemia has been noted [10]. There has been also a shift in the number or cases caused by Candida albicans in contrast to non- C. albicans cases, with more recent studies showing an increase in the cases of C. tropicalis , C. parapsillopsis , and C. glabrata [4,45,46,47]. A low frequency of fluconazole resistance has been observed among the three main identified species [4].…”

Section: Resultsmentioning

confidence: 99%

Burden of Fungal Infections in Colombia

Álvarez-Moreno

Cortés

Denning

2018

JoF

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Data with respect to the epidemiological situation of fungal diseases in Colombia is scarce. Thus, the aim of this study is to estimate the burden of fungal infections. A population projection for 2017 from the Colombian Department for National Statistics was used, as well as official information from the Ministry of Health and National Institute of Health. A bibliographical search for Colombian data on mycotic diseases and population at risk (chronic obstructive pulmonary disease, HIV infection/AIDS, cancer, and transplant patients) was done. The Colombian population for 2017 was estimated at 49,291,609 inhabitants, and the estimated number of fungal infections for Colombia in 2017 was between 753,523 and 757,928, with nearly 600,000 cases of candidiasis, 130,000 cases of aspergillosis, and 16,000 cases of opportunistic infection in HIV, affecting around 1.5% of the population. In conclusion, fungal infections represent an important burden of disease for the Colombian population. Different clinical, epidemiological, and developmental scenarios can be observed in which fungal infections occur in Colombia.

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“…OR IC95% P A-OR IC95% P Se encontró que el principal agente causal de candidemia fue Candida albicans predominando sobre las especies no albicans; resultado que concuerda con los reportados por otros estudios realizados en nuestro país (15,20,21), y los descritos en otras investigaciones similares (22-24) realizadas en otros países, no obstante, difi eren a los reportados por Horn et al (3), quienes en una cohorte de 2009 pacientes con candidemia reportaron a las especies no albicans como agente causal en el 54,4% de los pacientes, pese a la presencia predominante de estas especies que pudo ser causada por la presión selectiva ejercida sobre Candida albicans por el uso previo de fl uconazol, el cual fue descrito por Chow et al (25) como factor de riesgo para candidemia por especies no albicans.…”

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Influencia de la colonización de vía aérea por Candida spp. en pacientes con Enfermedad Pulmonar Obstructiva Crónica en una unidad de cuidado intensivo de Colombia, durante el periodo 2010 a 2015.

Fandiño¹,

Caicedo²,

Urrutia-Gómez

et al. 2017

rev cuarzo

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ResumenCandida spp. es el agente más comúnmente aislado de origen fúngico en el contexto de Unidad de Cuidados Intensivos (UCI), La EPOC es una enfermedad caracterizada por una obstrucción crónica del flujo aéreo pulmonar, constituye un factor predisponente de colonización de la vía aérea por Candida spp. Metodología: Se realizó un estudio de caso comparativo de tipo retrospectivo revisando los registros microbiológicos de aislamientos de muestras orotraqueales de Candida spp entre 2010 y 2015 de pacientes con diagnóstico espirométrico de EPOC, el grupo de comparación fue formado por pacientes con aislamiento de Candida spp. sin diagnóstico de EPOC, se revisó la historia clínica en busca de variables, demográficas, clínicas, terapéuticas y microbiológicas. Las variables discretas se describieron mediante frecuencia relativa y absoluta, mientras que las variables continuas se describieron mediante promedio e IC del 95%. Resultados: 116 pacientes fueron incluidos, 43 en el grupo de EPOC y 73 pacientes en grupo de comparación. No hubo diferencias significativas entre las especies aisladas, siendo el más prevalente Candida albicans con 76.74% de los aislamientos de los pacientes con EPOC y 75.34% de Pacientes sin EPOC, los pacientes con EPOC eran de mayor edad comparados con los de no-EPOC y presentaron un mayor Índice de Charlson comparado con el otro grupo. Dentro de las condiciones clínicas no se observaron diferencias significativas entre los grupos; sin embargo, se presentó mayor mortalidad en los pacientes con EPOC con un 53.49% comparado con el 20.55% del otro grupo de estudio (p<0.01). Conclusión: La colonización por Candida spp se hace relevante como un factor asociado a aumento de la mortalidad en pacientes con. EPOC en contexto de UCI.

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Clinical and epidemiological characteristics and risk factors for mortality in patients with candidemia in hospitals from Bogotá, Colombia

Abstract: Candidemia is associated with a high mortality rate. Age and shock increase mortality, while the use of fluconazole was shown to be a protective factor. A higher resistance rate with new breakpoints was noted.

Cited by 30 publications

References 29 publications

Surveillance and characterization of Candida bloodstream infections in a Serbian tertiary care hospital

Surveillance and characterization of Candida bloodstream infections in a Serbian tertiary care hospital

Burden of Fungal Infections in Colombia

Influencia de la colonización de vía aérea por Candida spp. en pacientes con Enfermedad Pulmonar Obstructiva Crónica en una unidad de cuidado intensivo de Colombia, durante el periodo 2010 a 2015.

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