A simple mathematical model to determine the ideal empirical antibiotic therapy for bacteremic patients

Tuon, Felipe Francisco; Rocha, Jaime L.; Leite, Talita M.; Dias, Camila

doi:10.1016/j.bjid.2013.11.006

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Although there has been several reports dealing with the increasing resistance to meropenem, in the last two years, from microorganisms that grow in intensive care units and hospital facilities, this antimicrobial substance still is one of the best empirical drug for first option for severe critically infected ill patients without knowing the bacteriological tests 15 .…”

Section: Several Interventional Approaches For Treatingmentioning

confidence: 99%

Severe autogenously fecal peritonitis in ageing Wistar rats. Response to intravenous meropenem

Mascena

Melo²,

Gadelha³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate the treatment outcome of severe peritonitis in rats with increasing age. METHODS:Thirty Wistar rats stratified in three groups: group I -six month-old; group II -12 month-old; and group III -18 monthold, underwent autogenously fecal peritonitis (6 ml/kg rat), and were treated with intravenous meropenem. The survival animals were followed-up for 45 days. The variables were expressed by their mean and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee. RESULTS:There was a significant increase in the mortality and morbidity in elderly rats. Of interest, even among young survival rats presenting with severe residual abscesses both in the abdomen and thorax cavities, they present an almost normal life. CONCLUSIONS:The treatment of severe autogenously fecal peritonitis with intravenous meropenem reached reasonable results in rats with six and twelve months of age, even considering residual abscesses on abdomen and thorax cavities. However, the great majority (80%) of elderly rats could not overcome the initial severe infectious challenge, proving that ageing is a very important risk factor for impairing immune response. Thus, sepsis remains a challenging situation, especially in elderly.

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Section: Several Interventional Approaches For Treatingmentioning

confidence: 99%

Severe autogenously fecal peritonitis in ageing Wistar rats. Response to intravenous meropenem

Mascena

Melo²,

Gadelha³

et al. 2014

Acta Cir. Bras.

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show abstract

“…In patients with severe sepsis, the decision of selection of the combination therapy must be taken in the first hours of diagnosis [ 7 ]. It has been reported that the initial use of proper combination therapy improves outcomes in patients with sepsis or ventilator-associated pneumonia (VAP) caused by Gram-negative bacteria [ 3 , 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Microdilution Method to Assess Double and Triple Antibiotic Combination TherapyIn Vitro

El-Azizi

2016

International Journal of Microbiology

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An in vitro microdilution method was developed to assess double and triple combinations of antibiotics. Five antibiotics including ciprofloxacin, amikacin, ceftazidime, piperacillin, and imipenem were tested against 10 clinical isolates of Pseudomonas aeruginosa. Each isolate was tested against ten double and nine triple combinations of the antibiotics. A 96-well plate was used to test three antibiotics, each one alone and in double and triple combinations against each isolate. The minimum bacteriostatic and bactericidal concentrations in combination were determined with respect to the most potent antibiotic. An Interaction Code (IC) was generated for each combination, where a numerical value was designated based on the 2-fold increase or decrease in the MICs with respect to the most potent antibiotic. The results of the combinations were verified by time-kill assay at constant concentrations of the antibiotics and in a chemostat. Only 13% of the double combinations were synergistic, whereas 5% showed antagonism. Forty-three percent of the triple combinations were synergistic with no antagonism observed, and 100% synergism was observed in combination of ciprofloxacin, amikacin, and ceftazidime. The presented protocol is simple and fast and can help the clinicians in the early selection of the effective antibiotic therapy for treatment of severe infections.

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Clinical utility of prior positive cultures to optimize empiric antibiotic therapy selection: A cross-sectional analysis

Khasawneh,

Almomani,

Al‐Shatnawi

et al. 2023

New Microbes and New Infections

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A simple mathematical model to determine the ideal empirical antibiotic therapy for bacteremic patients

Abstract: Association of three drugs is necessary for adequate coverage of empirical treatment of bacteremia in both the intensive care unit and the ward.

Cited by 4 publications

References 14 publications

Severe autogenously fecal peritonitis in ageing Wistar rats. Response to intravenous meropenem

Severe autogenously fecal peritonitis in ageing Wistar rats. Response to intravenous meropenem

Novel Microdilution Method to Assess Double and Triple Antibiotic Combination TherapyIn Vitro

Clinical utility of prior positive cultures to optimize empiric antibiotic therapy selection: A cross-sectional analysis

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