Microsporum spp. onychomycosis: disease presentation, risk factors and treatment responses in an urban population

Martínez, Emmanuel; Ameen, Mahreen; Tejada, Diana; Arenas, Roberto

doi:10.1016/j.bjid.2013.08.005

Cited by 26 publications

(11 citation statements)

References 32 publications

(36 reference statements)

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“…The global prevalence of onychomycosis is estimated to be around 5.5%, attributing to 50.0% of all nail disease cases . The risk of onychomycosis increases with age due to poor peripheral circulation, diabetes, repeated nail trauma, longer exposure to pathogenic fungi, suboptimal immune function, inactivity, and/or the inability to maintain good foot care . Toenail onychomycosis is more common in males with Candida fingernail onychomycosis more common in women .…”

Section: Epidemiologymentioning

confidence: 99%

Global perspectives for the management of onychomycosis

et al. 2018

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Onychomycosis is a fungal nail infection caused by dermatophytes, nondermatophyte molds, and yeasts. This difficult‐to‐treat chronic infection has a tendency to relapse despite treatment. This paper aims to offer a global perspective on onychomycosis management from expert physicians from around the world. Overall, the majority of experts surveyed used systemic, topical, and combination treatments approved in their countries and monitored patients based on the product insert or government recommendations. Although the basics of treating onychomycosis were similar between countries, slight differences in onychomycosis management between countries were found. These differences were mainly due to different approaches to adjunctive therapy, rating the severity of disease and use of prophylaxis treatment. A global perspective on the treatment of onychomycosis provides a framework of success for the committed clinician with appreciation of how onychomycosis is managed worldwide.

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Section: Epidemiologymentioning

confidence: 99%

Global perspectives for the management of onychomycosis

et al. 2018

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“…In addition, the location of the clinical lesions, which covered the edge of the foot and toenails in two of the three described cases, did not indicate a zoonotic origin of the dermatomycosis and might suggest rather a geophilic source. In the literature, there are also reports on exceptional cases of tinea pedis and onychomycosis caused by N. nana [26,27]. Furthermore, N. nana reservoirs should also be sought in soil, and the information on the dual nature of this dermatophyte, both zoophilic and geophilic, seems to be relevant [28].…”

Section: Discussionmentioning

confidence: 99%

Unusual dermatomycoses caused by Nannizzia nana: the geophilic origin of human infections

et al. 2020

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Background Fungal infections of the skin, hair, and nails are the largest and most widespread group of all mycoses. Nannizzia nana is a relatively rare etiological factor of dermatomycosis in humans, as it usually affects animals, e.g. pigs and boars. In addition to the zoophilic nature, there are also reports of the geophilic reservoir of this dermatophyte species. Objective In this study, we present symptomatic infections with N. nana aetiology in humans reported recently in Poland. Interestingly, these cases had a non-specific clinical picture and occurred as skin lesions on the neck and foot as well as onychomycosis of the toenails. From the medical history, the patients had no contact with pigs. Methods Diagnostics of these infections was performed with a combination of classical phenotypic and molecular genomic methods. The genomic diversity of the isolates was determined using the MP-PCR method. In vitro antifungal susceptibility tests against itraconazole, ketoconazole, terbinafine and naftifine hydrochloride were also performed. Results Nannizzia nana has been identified as an etiological factor of dermatomycosis. Moreover, heterogeneity of the genomes was revealed for the obtained strains. In vitro activities of antifungal agents showed that isolates were susceptible to all tested drugs. The patients were treated with oral terbinafine and topical ketoconazole cream, which led to a complete recovery. Conclusions In conclusion, the cases studied by us may indicate that the infrequency of N. nana infections may not necessarily be related to the low infectivity of this fungal agent, but they are rather associated with misdiagnosis. Furthermore, N. nana reservoirs should also be sought in soil.

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“…Geophilic dermatophytes are keratinophilic fungi able to grow on keratin baits in soil. These fungal species represent the largest group among dermatophytes and are not frequently found to infect humans or animals [14] , except for M. gypseum , occurring in about 0.1% of human patients [15] , [16] and in 1.1% of dermatologically diseased dogs and cats [17] . Infections due to geophilic fungi usually do not occur simultaneously in several animals, although an outbreak of dermatophytosis caused by Microsporum nanum has been described in an extensive Iberian pig farm [18] .…”

Section: Discussionmentioning

confidence: 99%

Dermatophytosis in donkeys (Equus asinus) due to Microsporum racemosum, an unusual geophilic agent

Nardoni

Rocchigiani

Papini

et al. 2016

Medical Mycology Case Reports

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Reports about ringworm in donkeys are scanty and refer to zoonotic agents such as Trichophyton mentagrophytes and Trichophyton verrucosum. Seventeen Asino Amiatina donkeys semi-extensively farmed in paddocks showed alopecic nummular, scaling areas mainly on head and neck. Microsporum racemosum cultivated from the lesions was identified by morphology and PCR. Affected animals healed spontaneously. The present record reports for the first time the occurrence of ringworm due to M. racemosum in naturally infected animals.

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Microsporum spp. onychomycosis: disease presentation, risk factors and treatment responses in an urban population

Cited by 26 publications

References 32 publications

Global perspectives for the management of onychomycosis

Global perspectives for the management of onychomycosis

Unusual dermatomycoses caused by Nannizzia nana: the geophilic origin of human infections

Dermatophytosis in donkeys (Equus asinus) due to Microsporum racemosum, an unusual geophilic agent

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