Epidemiologic profile of Streptococcus agalactiae colonization in pregnant women attending prenatal care in a city of southern of Brazil

Kruk, Cássia Rejane; Feuerschuette, Otto Henry May; Silveira, Sheila Koetker; Cordazo, Mayara; Júnior, Alberto Trapani

doi:10.1016/j.bjid.2013.07.003

Cited by 9 publications

(8 citation statements)

References 4 publications

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“… 21 (p <0.05), but it differs from the study by Kruk et al . 20 , in which urinary infection was not significant in GBS colonization in women (p = 0.191). It was not possible to identify which pathogen caused urinary tract infections in pregnant women because this variable was not reported by the interviewees.…”

Section: Discussionmentioning

confidence: 90%

“…Colonization of pregnant women at the beginning of gestation has no predictive value regarding neonatal infection. This period was determined because it is considered that GBS colonization can be transient, and it is relevant to know the colonization frequency in the period near birth 20 . In the present study, the majority (43.1%) of women was in the 35 th week of gestation, and 38.3% of these were colonized by GBS; however, the gestational age at the time of collection was not associated with the presence of GBS (p = 0.387).…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Streptococcus agalactiae colonization in pregnant women from the 18th Health Region of Paraná State

Melo

Costa

Silva

et al. 2018

Rev. Inst. Med. trop. S. Paulo

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Introduction The aim of this study was to determine the prevalence of GBS colonization in pregnant women in a public health service.Methods A study of 496 pregnant women at 35-37 gestational weeks was conducted from September 2011 to March 2014 in 21 municipalities of the 18th Health Region of Paraná State. Vaginal and anorectal samples of each woman were plated on sheep blood agar, and in HPTH and Todd-Hewitt enrichment broths.Results Of the 496 pregnant women, 141 (28.4%) were positive for GBS based on the combination of the three culture media with vaginal and anorectal samples. The prevalence was 23.7% for vaginal samples and 21.9% for anorectal ones. Among the variables analyzed in this study, only urinary infection was a significant factor (0.026) associated with GBS colonization in women.Conclusions Based on these results, health units should performs universal screening of pregnant women and hospitals should provide adequate prophylaxis, when indicated.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Prevalence of Streptococcus agalactiae colonization in pregnant women from the 18th Health Region of Paraná State

Melo

Costa

Silva

et al. 2018

Rev. Inst. Med. trop. S. Paulo

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“…In the present study, presence of vaginal discharge was the only characteristic statistically associated with a higher occurrence of GBS colonization, although a strong trend between white pregnant women and lower occurrence of GBS colonization was also seen. Likewise, in a study performed in Santa Catarina, a state located in the South region of Brazil, presence of vaginal discharge and Afro-American ethnicity were characteristics associated with higher prevalence of GBS colonization among pregnant women [ 35 ]. In addition, in a study conducted in Ceará, a state located in the Northeast region of Brazil, belonging to white ethnicity was the only characteristic associated with lower prevalence of GBS colonization among 213 pregnant women investigated from 2008 to 2010 [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Streptococcus agalactiae carriage among pregnant women living in Rio de Janeiro, Brazil, over a period of eight years

et al. 2018

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Group B Streptococcus (GBS) carriage by pregnant women is the primary risk factor for early-onset GBS neonatal sepsis. Intrapartum antibiotic prophylaxis (IAP) can prevent this transmission route, and two main approaches are recommended to base the selection of pregnant women to be submitted to IAP: the risk-based and the culture-based strategies. In Brazil, compliance to such recommendations is poor, and not much is known about GBS carriage. In the present study, 3,647 pregnant women living in Rio de Janeiro State, Brazil, were screened for GBS anogenital colonization, over a period of 8 years (2008–2015). GBS was detected in 956 (26.2%) of them, and presence of vaginal discharge was the only trait associated with a higher risk for GBS colonization. Serotypes Ia (257; 37.3%) and II (137; 19.9%) were the most frequent among 689 (72.1% of the total) GBS isolates evaluated, followed by NT isolates (84; 12.1%), serotype Ib (77; 11.1%), V (63; 9.1%), III (47; 6.8%) and IV (24; 3.5%). Estimated coverage of major serotype-based GBS vaccines currently under clinical trials would vary from 65.2% to 84.3%. All 689 isolates tested were susceptible to ampicillin and vancomycin. Resistance to chloramphenicol, clindamycin, erythromycin, levofloxacin, and tetracycline was observed in 5% (35), 2% (14), 14% (97), 5% (35) and 86% (592) of the isolates, respectively. No significant fluctuations in colonization rates, serotype distribution and antimicrobial susceptibility profiles were observed throughout the period of time investigated. The culture-based approach for IAP recommendation showed to be the best choice for the population investigated when compared to the risk-based, since the first did not increase the number of pregnant women submitted to antibiotic therapy and covered a larger number of women who were actually colonized by GBS. The fact the not all isolates were available for additional characterization, and serotype IX antiserum was not available for testing represent limitations of this study. Nevertheless, to the best of our knowledge, this is the largest investigation on GBS carriage among pregnant women in Brazil up to date, and results are useful for improving GBS prevention and treatment strategies.

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“…However, we did not identify, as described elsewhere, maternal age, gestational diabetes, premature rupture of membranes and premature delivery threat as risk factors for GBS colonization [9,23]. Other risk factors were also associated to GBS colonization such as leukorrhea and prolonged labor [6,24]. Knowledge about risk factors associated to maternal colonization will be useful for better care of pregnant women and to reduce morbidity and mortality related to GBS diseases.…”

Section: Resultsmentioning

confidence: 88%

Prevalence, Antimicrobial Susceptibility and Macrolide Molecular Study in Vaginal Group B Streptococcus: A Five-Year Study among Pregnant Women Attending Antenatal Clinics in a Tertiary Care Hospital in Tunisia

Hela¹,

Syrine²,

Manel³

et al. 2020

Res Rev Infect Dis

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Background: Group B Streptococcus (GBS) is an important perinatal pathogen. It is considered as a leading cause of stillbirth and early onset neonatal infections. The epidemiology of maternal GBS colonization is poorly understood in Tunisia. We investigated genital GBS carriage prevalence and its associated risk factors in pregnant women. Antibiotic susceptibility was evaluated for isolated strains; macrolide gene resistance and capsular serotyping were also performed.Methods: A retrospective study conducted during 4 years at Aziza Othmana hospital of Tunis, Tunisia in pregnant women. Sampling was performed by vaginal swab. GBS was isolated by culture on selective medium; capsular serotyping was performed by rapid agglutination on Latex (PastorexStrepto B, Biorad®).Antibiotic susceptibility was performed according to the recommendations of the Antibiogram Committee of the French Society of Microbiology. Macrolide resistance was studied by a multiplex PCR assay.Results: A total of 3839 pregnant women was enrolled in the study; mean age was 31 ± 5 years A carriage GBS prevalence was estimated to 12.7% (486/3869). It was significantly associated to primiparity, third gestational trimester, altered vaginal flora and Candida co-infection. No significant association wasobserved with gestational diabetes, membranes premature rupture and premature delivery threat. The most frequent serotypes were serotype III (33.3%), II (12.8%) and I (5.1%). All GBS strains were sensitive to beta-lactams and glycopeptides; only one strain was resistant to pristinamycin and another had high level resistance to gentamycin. Tetracycline resistance was observed in 96.1% of cases. Resistance to macrolides and lincosamides was detected in 37% and 32.4% respectively. A constitutive macrolide-lincosamidestreptogramin B (MLS(B)) phenotype was observed in 73.5% of cases, the inducible type MLS(B) in 14.8% of cases and the M phenotype in 11.7% of cases. Erm(B), erm(TR) and mef (A) genes were found in 79.4%, 15.3% and 12.9% of erythromycin resistant strains. Conclusion:Vaginal GBS screening and intrapartum antibiotic prophylaxis are the most effective way to reduce early neonatal bacterial infections. Beta-lactams remain the antibiotics of choice. When allergy is diagnosed, antibiotic susceptibility is compulsory to choose an alternative such as clindamycine.

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Epidemiologic profile of Streptococcus agalactiae colonization in pregnant women attending prenatal care in a city of southern of Brazil

Cited by 9 publications

References 4 publications

Prevalence of Streptococcus agalactiae colonization in pregnant women from the 18th Health Region of Paraná State

Prevalence of Streptococcus agalactiae colonization in pregnant women from the 18th Health Region of Paraná State

Streptococcus agalactiae carriage among pregnant women living in Rio de Janeiro, Brazil, over a period of eight years

Prevalence, Antimicrobial Susceptibility and Macrolide Molecular Study in Vaginal Group B Streptococcus: A Five-Year Study among Pregnant Women Attending Antenatal Clinics in a Tertiary Care Hospital in Tunisia

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