Cervical spondylitis and spinal abscess due to Actinomyces meyeri

Duvignaud, Alexandre; Ribeiro, E.; Moynet, Daniel; Longy‐Boursier, M.; Malvy, Denis

doi:10.1016/j.bjid.2013.05.016

Cited by 17 publications

(8 citation statements)

References 9 publications

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“…Typically, the patients' dentition and oral hygiene are poor, which are predisposing factors for the disease to occur. A recent report described an actinomycotic case with an involvement of the cervical spine, where A. meyeri was isolated from prevertebral pus samples and blood (136). Among 15 actinomycotic cases with an involvement of thoracic vertebral bone, however, A. israelii was detected in 9 of the cases, and A. meyeri was detected in 1 (137).…”

Section: Other Types Of Actinomycosismentioning

confidence: 99%

Actinomyces and Related Organisms in Human Infections

2015

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SUMMARY Actinomyces israelii has long been recognized as a causative agent of actinomycosis. During the past 3 decades, a large number of novel Actinomyces species have been described. Their detection and identification in clinical microbiology laboratories and recognition as pathogens in clinical settings can be challenging. With the introduction of advanced molecular methods, knowledge about their clinical relevance is gradually increasing, and the spectrum of diseases associated with Actinomyces and Actinomyces -like organisms is widening accordingly; for example, Actinomyces meyeri , Actinomyces neuii , and Actinomyces turicensis as well as Actinotignum (formerly Actinobaculum ) schaalii are emerging as important causes of specific infections at various body sites. In the present review, we have gathered this information to provide a comprehensive and microbiologically consistent overview of the significance of Actinomyces and some closely related taxa in human infections.

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Section: Other Types Of Actinomycosismentioning

confidence: 99%

Actinomyces and Related Organisms in Human Infections

2015

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“…21 Surgery may be recommended to drain the lesion and remove the site of infection, but high doses of penicillin for a prolonged time is the treatment of choice. 9,21 Mortality rates of treated human patients can be high, up to 28% in a previous report. 10 In dogs, Actinomyces spp.…”

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confidence: 88%

Long-term survival in a dog with meningoencephalitis and epidural abscessation due to Actinomyces species

et al. 2015

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A 2-year-old, female spayed Golden Retriever dog was presented to The Ohio State University Veterinary Medical Center for evaluation of ataxia, cervical pain, 1 episode of acute collapse, dull mentation, and inappetence. Physical examination revealed an elevated temperature of 39.7°C and severe cervical pain. Blood work revealed a mature neutrophilia. Cerebrospinal fluid (CSF) analysis revealed nondegenerative neutrophilic pleocytosis with no infectious agents. A presumptive diagnosis of steroid-responsive meningitis-arteritis was made, and corticosteroid therapy was started. The patient improved initially but experienced a vestibular episode characterized by falling and vertical nystagmus. A magnetic resonance imaging of the brain revealed an epidural abscess in the cervical vertebral canal and diffuse meningeal enhancement in the brain and cranial cervical spine. Abscess drainage revealed degenerate neutrophils and several filamentous, branching organisms. Culture of the initial CSF using an enrichment broth revealed growth of a Gram-positive organism 5 days after fluid collection. The isolate was identified by partial 16S ribosomal DNA sequencing as Actinomyces spp. The patient was successfully treated with long-term antibiotics. Our study reports the long-term survival after medical treatment of bacterial meningoencephalitis and epidural abscessation due to Actinomyces sp. infection in a dog. Bacterial meningoencephalitis should be included as a differential diagnosis in patients with cervical pain and fever, even when a nondegenerative neutrophilic pleocytosis is found on CSF analysis. Culture of the CSF with use of an enrichment broth should be considered in all cases of neutrophilic pleocytosis to rule out infections of the central nervous system.

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“…Other cases reported intracranial actinomycosis [3][4][5][6]9], but in none of them A. meyeri was recognized as the causative pathogen of primary brain abscess. Only one recent article [10] has reported a cervical actinomycosis with paravertebral abscess and spondylitis imputed to an infection by A. meyeri: in this case an avulsion of teeth 46 and 47, presumed to be the entry point of the infectious process.…”

Section: Less Common Species Include a Naeslundii A Odontolyticusmentioning

confidence: 99%

Brain Abscess Sustained by Actinomyces meyeri in an Immunocompetent Patient

Guardigni¹

2013

J Neurol Neurophysiol

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Actinomycosis is a rare granulomatous disease, caused by filamentous Gram positive anaerobic bacteria, which may become pathogenic following disruption of anatomical barriers with invasion of host’s deep tissues and dissemination of infection to any site of the organism. A. israelii is found in most clinical presentations. We describe a case of a 41 years-old immunocompetent woman affected by thalamic abscess due to Actinomyces meyeri, presenting with fever, headache, vomit, confusion. A brain Computed Tomography (CT) and a Magnetic Resonance Imaging (MRI) revealed an expansive thalamic lesion with wide central necrosis and perilesionaledema. The patient was immediately addressed to a first evacuation of the mass, followed by a second drainage because of recurrence of the abscess. Microbiological and histological findings from intraoperatory specimens, resulted positive for A. meyeri. Ampicillin 20 g plus rifampicin 1200 mg/day was started, followed by ceftriaxon 4 g/day for 2 weeks and by amoxicillin 3 g/day. The treatment was discontinued after 9 months; brain MRIs performed at the end of therapy and after 3 and 6 months from the interruption of therapy revealed a gradual but complete resolution of cerebral abscess. Actinomycosis is an infrequent but severe disease that can mimic tuberculosis, nocardiosis and malignancies. Cases of cerebral actinomycosis reported in literature are limited, but those from A. meyeri are extremely rare. Moreover this pathogen is often related to disseminated disease, especially in immunocompromised patients. There is no consensus about treatment of cerebral actinomycosis: different types of regimens are proposed; we firstly administered ampicillin (12-16 g/day for at least six months), plus rifampicin, to enhance their penetration in CNS. Actinomycosis requires a prompt diagnosis and antibiotic treatment (often in combination with surgery) in order to avoid dissemination and prevent complications

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Cervical spondylitis and spinal abscess due to Actinomyces meyeri

Cited by 17 publications

References 9 publications

Actinomyces and Related Organisms in Human Infections

Actinomyces and Related Organisms in Human Infections

Long-term survival in a dog with meningoencephalitis and epidural abscessation due to Actinomyces species

Brain Abscess Sustained by Actinomyces meyeri in an Immunocompetent Patient

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