The association of HLA-DRB1 alleles and drug use with HIV infection in a Chinese Han Cohort

Abstract

There is close relationship between the polymorphism of HLA-DRB1 alleles and drug use with HIV infection, which plays an important role in elucidating the pathogenesis and providing the basis for therapeutics and prophylaxis of patients with drug use and HIV infection.

Polymorphisms in HLA-DRB1 Gene and the Risk of Tuberculosis: A Meta-analysis of 31 Studies

“…T cells play a central role in immune protection which recruits neutrophils, eosinophils, and basophils to sites of infection and inflammation, to help B cells make antibodies, to induce macrophages to develop enhanced microbicidal activity, and through their production of cytokines and chemokines, to orchestrate the full panoply of immune responses [7]. Thereby, lot of studies demonstrated that there is close relationship between the HLA gene polymorphisms and infection disease, cancer, inflammatory, and autoimmune disease [8][9][10][11][12][13]. In addition, growing studies found that the HLA Class II gene, especially HLA-DRB1 gene polymorphisms, might significantly influence of TB risk [14][15][16], but the results have been inconclusive.…”

Hla-Drb1 Gene Polymorphisms in Pediatric Patients With Type 1 Autoimmune Hepatitis and Type 1 Autoimmune Hepatitis Overlap Syndrome With Autoimmune Cholangitis

“…The polymorphisms evaluated were HLA-DRB1*03, HLA-DRB1*04, HLA-DRB1*07, and HLA-DRB1*13. The alleles sequence specific primers were designed based on previously reported reference (23) and confirmed from GenBank database. The primers were synthesized by Thermo Fisher Scientific, Invitrogen and Integrated DNA Technologies (IDT).…”