Leprosy and hepatitis B coinfection in southern Brazil

Leitão, Cleverson Alex; Ueda, Denis Massatsugu; Braga, Anna Carolina de Moraes; Boldt, Angelica Beate Winter; Messias-Reason, Iara

doi:10.1016/j.bjid.2013.04.003

Cited by 9 publications

(7 citation statements)

References 18 publications

(25 reference statements)

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“…However, we could find no evidence for any Mycobacterium tuberculosis (MTB) complex species. In some parts of the world, institutionalized patients suffering with multibacillary leprosy seem to be more susceptible to hepatitis due to hepatitis B virus [ 78 ]. Such associations have been reported in Brasil [ 79 ], Africa [ 80 , 81 ], India [ 82 ] and Greece [ 83 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of a Medieval Pilgrim Burial Excavated from the Leprosarium of St Mary Magdalen Winchester, UK

et al. 2017

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We have examined the remains of a Pilgrim burial from St Mary Magdalen, Winchester. The individual was a young adult male, aged around 18–25 years at the time of death. Radiocarbon dating showed the remains dated to the late 11th–early 12th centuries, a time when pilgrimages were at their height in Europe. Several lines of evidence in connection with the burial suggested this was an individual of some means and prestige. Although buried within the leprosarium cemetery, the skeleton showed only minimal skeletal evidence for leprosy, which was confined to the bones of the feet and legs. Nonetheless, molecular testing of several skeletal elements, including uninvolved bones all showed robust evidence of DNA from Mycobacterium leprae, consistent with the lepromatous or multibacillary form of the disease. We infer that in life, this individual almost certainly suffered with multiple soft tissue lesions. Genotyping of the M.leprae strain showed this belonged to the 2F lineage, today associated with cases from South-Central and Western Asia. During osteological examination it was noted that the cranium and facial features displayed atypical morphology for northern European populations. Subsequently, geochemical isotopic analyses carried out on tooth enamel indicated that this individual was indeed not local to the Winchester region, although it was not possible to be more specific about their geographic origin.

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Section: Discussionmentioning

confidence: 99%

Investigation of a Medieval Pilgrim Burial Excavated from the Leprosarium of St Mary Magdalen Winchester, UK

et al. 2017

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“…As a result, patients with lepromatous leprosy cannot generate an adequate immune response for HBV clearance, and this makes them vulnerable to co-infections. 15 In our study, three of the four patients with HBsAg presence were patients with lepromatous leprosy. Moreover, nine of the 16 patients with Anti-HCV presence were again patients with lepromatous leprosy and these numbers are in accordance with the previous literature findings.…”

Section: Discussionmentioning

confidence: 57%

“…In studies from Brazil, 25.5% to 39.7% of the patients with leprosy had a positive HBV marker. 15,16 In Senegal, a study evaluated 987 leprosy patients and revealed similar results (23-25.5%). 17 In our study, we did not encounter any isolated Anti-HBc presence and there was a 47.0% anti-HBs presence.…”

Section: Discussionmentioning

confidence: 74%

Hepatitis B and C Seroprevalence in Leprosy Patients

Kaygusuz¹,

Özgüler²,

Güngör³

et al. 2015

Journal of Microbiology and Infectious Diseases

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Objective: Leprosy is a contagious chronic granulomatous disease and commonly affects the eyes and the internal organs. Leprosy can be classified according to the level of immune response. Leprosy is a disease that is associated with defects in cellular immunity. This is why we have investigated the leprosy patients that were referred to our hospital for chronic hepatitis B and C co-infections.Methods: Fifty patients who were treated in the leprosy unit of Elazığ Research and Training hospital between the dates of June-December 2011 were enrolled to this descriptive study. Macro ELISA assay was performed for Hepatitis B,C and HIV.Results: Fifty patients who were treated in the leprosy unit of our hospital participated in the study. A total of 8% HBsAg presence was noted. A total of 16 Anti HCV presence was noted in the patient group. Anti HCV positivity was determined at seven of 14 patients with tuberculoid form leprosy (50%) and nine of 33 lepromatous leprosy form (27,2%). Conclusion:In conclusion, leprosy patients, especially lepromatous leprosy group, are immunologically vulnerable to HBV and HCV co-infections. Thus, physicians should be aware of HBV coinfections in these patients and education should be given to patients to increase their knowledge regarding risky situations for transmission of the disease.

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“…Patients with leprosy may have an immunological impairment related to some clinical forms of the disease or due to the use of corticosteroids to control leprosy reactions . In addition, compared with the general population, a higher prevalence of serological markers of HBV in leprosy patients has been reported …”

Section: Introductionmentioning

confidence: 99%

“…2 In addition, compared with the general population, a higher prevalence of serological markers of HBV in leprosy patients has been reported. [3][4][5] Studies on the seroprevalence of HBV in leprosy have also analyzed the association of serological markers with the clinical form of the disease, with the leprosy operational classification 4,6-9 and with the occurrence of leprosy reactions. [9][10][11] However, HBV DNA, the molecular marker of HBV infection, has been poorly investigated in this group of patients.…”

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confidence: 99%

Occult hepatitis B virus infection in patients with leprosy

Costa

Morais

Gonçales

et al. 2018

Journal of Medical Virology

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Leprosy patients may present with immune system impairment and have a higher hepatitis B virus (HBV) seroprevalence, justifying the investigation of occult HBV infection in these individuals. The aim of this study was to verify the frequency and the clinical factors associated with occult HBV infection in leprosy patients. Between 2015 and 2016, leprosy patients from a reference center in Brazil were interviewed to assess clinical data. Blood samples were collected for the screening of HBV serological markers using enzyme‐linked immunosorbent assay. Patients with negative hepatitis B surface antigen (HBsAg) that had positive anti‐HBc and/or anti‐HBs were selected for HBV DNA detection using real‐time polymerase chain reaction. SPSS was used for data analysis. Among 114 selected patients, six were identified with occult infection (5.3%) and five of them with multibacillary leprosy. Three patients with occult infection had a history of a type 2 reaction (P = 0.072; OR, 4.97; 95% CI, 0.87‐28.52). Only two patients with occult infection had isolated anti‐HBc, while three had isolated anti‐HBs, including those with the highest HBV DNA titers. In conclusion, in leprosy patients with negative HBsAg and positive anti‐HBc and/or anti‐HBs, occult HBV infection occurs in 5.3% and can be found even in patients with isolated anti‐HBs.

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Leprosy and hepatitis B coinfection in southern Brazil

Cited by 9 publications

References 18 publications

Investigation of a Medieval Pilgrim Burial Excavated from the Leprosarium of St Mary Magdalen Winchester, UK

Investigation of a Medieval Pilgrim Burial Excavated from the Leprosarium of St Mary Magdalen Winchester, UK

Hepatitis B and C Seroprevalence in Leprosy Patients

Occult hepatitis B virus infection in patients with leprosy

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