Health related quality of life among patients with chronic hepatitis C: a cross-sectional study of sociodemographic, psychopathological and psychiatric determinants

Fábregas, Bruno Cópio; Ávila, Renata Eliane de; Faria, Marjore Novaes; Moura, Alexandre Sampaio; Carmo, Ricardo Andrade; Teixeira, Antônio Lúcio

doi:10.1016/j.bjid.2013.03.008

Cited by 36 publications

(40 citation statements)

References 43 publications

(42 reference statements)

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“…Patients were excluded from the study if they exhibited co-infection with the hepatitis B virus or human immunodefi ciency virus (HIV) or a low score on the MiniMental Status Examination, which was suggestive of a cognitive defi cit. This report is a component of a major project investigating the psychopathological characteristics of CHC patients and the clinical and laboratorial correlates of these characteristics 16,17 .…”

Section: Study Design Setting and Participantsmentioning

confidence: 99%

“…The patients were recruited from a referral center and may not have refl ected the overall population of CHC patients. This study did not use structured interviews or specific instruments for the comprehensive assessment of SD because the data were extracted from a broader project investigating the psychopathological characteristics of CHC patients 16,17 . In this context, we did not distinguish between specific SD symptoms, such as the loss of libido, premature ejaculation, erectile dysfunction and impotence.…”

Section: Rev Soc Bras Med Trop 47(5):564-572 Sep-oct 2014mentioning

confidence: 99%

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Sexual dysfunction and dissatisfaction in chronic hepatitis C patients

Fábregas

Moura

Ávila

et al. 2014

Rev. Soc. Bras. Med. Trop.

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564www.scielo.br/rsbmt I www.rsbmt.org.br Revista da Sociedade Brasileira de Medicina Tropical 47(5):564-572, Sep-Oct, 2014http://dx.doi. org/10.1590/0037-8682-0147-2014 Major Article ABSTRACT Introduction: The prevalence of sexual dysfunction (SD) and dissatisfaction with sexual life (DSL) in patients with chronic hepatitis C virus infection (CHC) was jointly investigated via a thorough psychopathological analysis, which included dimensions such as fatigue, impulsiveness, psychiatric comorbidity, health-related quality of life (HRQL) and sociodemographic and clinical characteristics. Methods: Male and female CHC patients from an outpatient referral center were assessed using the Brief Fatigue Inventory, the Barrat Impulsiveness Scale, the Beck Depression Inventory (BDI), the Hospital Anxiety and Depression Scale, the Hamilton Anxiety Scale (HAM-A), and the World Health Organization Quality of Life Scale-Brief Version (WHOQOL-BREF). Structured psychiatric interviews were performed according to the Mini-International Neuropsychiatric Interview. SD was assessed based on specifi c items in the BDI (item 21) and the HAM-A (item 12). DSL was assessed based on a specifi c question in the WHOQOL-BREF (item 21). Multivariate analysis was performed according to an ordinal linear regression model in which SD and DSL were considered as outcome variables. Results: SD was reported by 60 (57.1%) of the patients according to the results of the BDI and by 54 (51.4%) of the patients according to the results of the HAM-A. SD was associated with older age, female gender, viral genotype 2 or 3, interferon-α use, impulsiveness, depressive symptoms, antidepressant and benzodiazepine use, and lower HRQL. DSL was reported by 34 (32.4%) of the patients and was associated with depressive symptoms, anxiety symptoms, antidepressant use, and lower HRQL. Conclusions: The prevalence of SD and DSL in CHC patients was high and was associated with factors, such as depressive symptoms and antidepressant use. Screening and managing these conditions represent signifi cant steps toward improving medical assistance and the HRQL of CHC patients.

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Section: Study Design Setting and Participantsmentioning

confidence: 99%

Section: Rev Soc Bras Med Trop 47(5):564-572 Sep-oct 2014mentioning

confidence: 99%

Sexual dysfunction and dissatisfaction in chronic hepatitis C patients

Fábregas

Moura

Ávila

et al. 2014

Rev. Soc. Bras. Med. Trop.

Self Cite

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“…11,12 Few prospective studies have assessed HRQOL in CHC patients using detailed clinical and psychiatric approaches in combination with semi-structured interviews for psychiatric diagnosis. 13,14 Depressive symptoms have been extensively identified in adults with chronic health conditions, 15 and correlate negatively with HRQOL. Patients with CHC have a high prevalence of depressive disorders, 11,16 up to 70%, which is seven-fold higher than that found in the general population, independently of the degree of hepatic injury.…”

Section: Introductionmentioning

confidence: 99%

Depression rather than liver impairment reduces quality of life in patients with hepatitis C

Silva

Cunha

et al. 2015

Rev. Bras. Psiquiatr.

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Objective: Patients with chronic hepatitis C (CHC) have a poorer quality of life than those with other chronic liver diseases. However, some of the factors that determine health-related quality of life (HRQOL) in these patients, such as the degree of liver fibrosis, are still controversial. Therefore, the aim of the present study was to investigate the impact of CHC on HRQOL by conducting clinical, psychiatric, and sociodemographic evaluations. Methods: One hundred and twenty-four consecutive patients attending a referral center for hepatitis were evaluated using the Mini-International Neuropsychiatry Interview, the Hamilton Depression Rating Scale, the Hospital Anxiety and Depression Scale, and the Medical Outcomes Study 36-Item Short-Form Health Survey. Multiple linear regression analyses were used to quantify independent associations between HRQOL and the clinical, psychiatric, and sociodemographic variables of interest. Results: Reduced HRQOL was independently associated with major depressive disorder (MDD) and with elevated levels of alanine aminotransferase, but was not associated with hepatic cirrhosis. Conclusions: MDD rather than the grade of liver fibrosis was strongly associated with HRQOL impairment in patients with CHC. These findings highlight that, in patients with CHC, the psychological effects of the disease deserve more attention and the implementation of integrated medical, psychiatric, and psychological care may be helpful.

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“…Brazilian studies on this subject remain scarce 9,10,[15][16][17][18] and have focused on the prevalence of impulsive behaviors 10 and psychiatric disorders 9,15,17 in CHC sufferers and the impact of the disease on their quality of life 16,18 . The aim of this investigation was to estimate the prevalence of depressive symptoms and harmful alcohol use in patients with CHC at the onset of antiviral treatment and to evaluate the possible demographic, clinical and psychosocial correlates.…”

Section: Methodsmentioning

confidence: 99%

“…The prevalence of depressive symptoms and harmful alcohol use and their associated factors were estimated. To our knowledge, very few Brazilian studies have systematically investigated the sociodemographic and lifestyle characteristics (e.g., tobacco and illicit drug use, social support) of CHC patients at the beginning of antiviral treatment or examined the association of these characteristic with psychiatric conditions 10,[15][16][17] . Moreover, in the present study depressive symptoms and harmful alcohol use were evaluated using standardized instruments.…”

Section: Prevalence Of Depressive Symptoms and Harmful Alcohol Usementioning

confidence: 99%

Depressive symptoms and harmful alcohol use in hepatitis C patients: prevalence and correlates

Machado

Silva

Torres

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Introduction:It is important to understand the characteristics and vulnerabilities of people who have hepatitis C because this disease is currently an important public health problem. The objective of this study was to estimate the prevalence of depressive symptoms and harmful alcohol use in patients with hepatitis C and to study the association between these outcomes and demographic, psychosocial and clinical variables. Methods: This cross-sectional, descriptive and analytical study involved 82 hepatitis C patients who were being treated with pegylated interferon and ribavirin at a public university hospital. The primary assessments used in the study were the Alcohol Use Disorders Identifi cation Test and the Beck Depression Inventory. Bivariate analyses were followed by logistic regression. Results: The prevalence of depressive symptoms was 30.5% (n=25), and that of harmful alcohol use was 34.2% (n=28). Logistic regression analysis showed that individuals who were dissatisfi ed with their social support (OR=4.41; CI=1.00-19.33) and were unemployed (OR=6.31; CI=1.44-27.70) were at a higher risk for depressive symptoms, whereas harmful alcohol use was associated with the male sex (OR=6.78; CI=1. 38-33.19) and the use of illicit substances (OR=7.42; CI=1.12-49.00). Conclusions: High prevalence rates of depressive symptoms and harmful alcohol use were verifi ed, indicating vulnerabilities that must be properly monitored and treated to reduce emotional suffering in this population.

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Health related quality of life among patients with chronic hepatitis C: a cross-sectional study of sociodemographic, psychopathological and psychiatric determinants

Abstract: Depression and fatigue must be properly investigated and managed in HCV patients in order to improve HRQL. WHOQOL-BREF proved to be a useful instrument to assess HRQL in HCV patients.

Cited by 36 publications

References 43 publications

Sexual dysfunction and dissatisfaction in chronic hepatitis C patients

Sexual dysfunction and dissatisfaction in chronic hepatitis C patients

Depression rather than liver impairment reduces quality of life in patients with hepatitis C

Depressive symptoms and harmful alcohol use in hepatitis C patients: prevalence and correlates

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