First reported case of pneumonia caused by Cedecea lapagei in America

López, Luis Antonio Sánchez; Ibarra, Bárbara Saenz; Garza, Jess Alberto Cárdenas de la; Rada, Felipe de Jesús Martín Pérez; Nuñez, Ana Isabel Sepúlveda; López, María Guadalupe Rodríguez

doi:10.1016/j.bjid.2013.03.003

Cited by 15 publications

(8 citation statements)

References 11 publications

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“…Bu olgulardan 2'si pnömoni, 1'i idrar yolu enfeksiyonu ve 1'i de bakteriyemi olarak raporlanmıştır (10)(11)(12)(13). Tüm literatür bilgileri incelendiğinde Cadecea Lapagei'nin izole edilmiş olduğu enfeksiyon olgularının tamamı Tablo 2'de özetlenmiştir (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

Section: Discussionunclassified

İleri Evre Orofarenks Kanserli Bir Hastada Nekroze Enfekte Tümöral Kitlede Cedecea Lapagei Süperenfeksiyonu: Olgu Sunumu (Cedecea lapagei süperenfeksiyonu)

Tanrıverdi¹,

Sandal²,

Ateş³

et al. 2020

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

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Sıklıkla balgamdan izole edilen ve Enterobacteriaceae ailesinin bir üyesi olan Cedecea cinsi bakteriler ciltte normal florada bulunmazlar ancak gastrointestinal sistemde kolonize olabilirler. Buna karşın klinik önemleri henüz net değildir. Sıklıkla immunsupresyonu olan hastalarda gelişen Cedecea enfeksiyonlarının nadir olduğu belirtilmiştir. Literatürde bakteriyemi, abse, ülser, idrar yolu, pnömoni, göz ve yara enfeksiyonları nadir olgular olarak bildirilmiştir. Bu yazıda sisplatin, 5-fluorourasil, setuksimab anti-kanser ilaçlarından oluşan kombinasyon rejimi ile tedavi edilen ileri evre orofarenks skuamöz hücreli karsinom tanılı erkek hastada gelişen C. lapagei yara enfeksiyonu sunulmuştur.Cedecea type of bacteria that is isolated from sputum and a member of Enterobacteriaceae is not found in skin flora. However, it may be colonised in the gastrointestinal system. On the other hand, the clinical importance of it has not been well documented. It has been rarely reported in immunosuppressive individuals. In literature, it is reported that bacteraemia, abscess, ulcer, urinary tract infection, pneumonia, eye and wound infections associated with Cedecea lapagei are the rare cases. Here, were present a Cedecea lapagei related wound infection in a locally advanced oropharyngeal squamous cell carcinoma treated with cisplatin, 5-fluorouracil and cetuximab.

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Section: Discussionunclassified

İleri Evre Orofarenks Kanserli Bir Hastada Nekroze Enfekte Tümöral Kitlede Cedecea Lapagei Süperenfeksiyonu: Olgu Sunumu (Cedecea lapagei süperenfeksiyonu)

Tanrıverdi¹,

Sandal²,

Ateş³

et al. 2020

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

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“…Cedecea infections have been reported worldwide, with clinical cases occurring in the United States, India, Greece, Mexico, and Spain, as well as other countries (Table 1). In most cases, infections attributed to Cedecea have occurred in immunocompromised patients with underlying medical conditions such as uncontrolled diabetes mellitus (Bae and Sureka, 1981;Dalamaga et al, 2008a,b), chronic kidney disease (Peretz et al, 2013), renal or liver transplantation (Davis and Wall, 2006;Mawardi et al, 2010), chronic obstructive pulmonary disease (COPD) (Perkins et al, 1986;Hong et al, 2015), and various malignancies (Abate et al, 2011;Akinosoglou et al, 2012;Lopez et al, 2013;Biswal et al, 2015). Cedecea species have also been isolated from venous and urinary access catheters (Ginn et al, 2018;Perkins et al, 1986;Abate et al, 2011).…”

Section: Human Infectionsmentioning

confidence: 99%

“…C. lapagei has been isolated from the following clinical specimens: blood (5 isolates) (Dalamaga et al, 2008a;Islam et al, 2016;Ahmad et al, 2017;Kury et al, 2017;Ramaswamy et al, 2019), sputum (4 isolates) (Hong et al, 2015;Lopez et al, 2013;Kury et al, 2017;Ramaswamy et al, 2019), lung tissue (1 isolate) (Coudron and Markowitz, 1987), knee wound site (1 isolate) (Dalamaga et al, 2008a), peritoneal dialysis fluid (1 isolate) (Davis and Wall, 2006), oral ulcer (1 isolate) (Biswal et al, 2015), and bulla liquid (1 isolate) (Chavez Herrera et al, 2018). Patients with C. lapagei had risk factors for opportunistic infection, such as acute leukemia, type II diabetes mellitus, pulmonary tuberculosis, liver transplantation, liver cirrhosis, and COPD (Table 1).…”

Section: Cedecea Lapageimentioning

confidence: 99%

Expanding spectrum of opportunistic Cedecea infections: Current clinical status and multidrug resistance

Thompson

Sharkady

2020

International Journal of Infectious Diseases

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Members of the bacterial genus Cedecea cause acute infections worldwide in compromised hosts with serious underlying medical conditions. While global reports of Cedecea infections remain sporadic in the medical literature, cases of multidrug-resistant clinical isolates have been documented each year over the past decade, warranting a comprehensive update on this emerging opportunistic pathogen. Here, we review the clinical manifestations, pathogenesis, natural distribution, epidemiology, and antimicrobial resistance of Cedecea species. Acute infection commonly manifests as bacteremia and pneumonia; however, the spectrum of infectious pathologies associated with Cedecea has expanded to include oral and cutaneous ulcers, orbital cellulitis, and peritonitis. The frequency of resistance among reported clinical isolates was highest to ampicillin, cephalothin, cefoxitin, cefazolin, and ceftazidime. Cedecea isolates harboring metallo-β-lactamases exhibited resistance to carbapenems and fourth-generation cephalosporins. Further research is needed to understand the pathogenicity and multidrug resistance of Cedecea species. Appropriate therapeutic management of Cedecea infections depends on antibiotic susceptibility testing because of variable resistance patterns and the enhanced infection risk in vulnerable populations.

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“…Documented infections associated with C. davisae include bacteremia in patients with cancer [ 3 ], chronic renal disease, [ 4 ] and diabetes mellitus [ 5 ], as well as a scrotal abscess in an individual with chronic heart disease and alcoholic hepatitis [ 6 ]. C. lapagei has been reported to cause pneumonia in patients with acute promyelocytic leukemia [ 7 ], chronic obstructive pulmonary disease [ 8 , 9 ], and hypoxic ischemic encephalopathy [ 10 ]. To date, C. neteri has been reported previously in only three documented clinical cases: a bacteremic patient with valvular heart disease [ 11 ], a systemic lupus erythematosus individual who developed an acute flare-up with bacteremia due to C. neteri [ 12 ], and a patient with a polymicrobial peritonitis infection following abdominal surgery [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary Catheter Colonization by Multidrug-ResistantCedecea neteriin Patient with Benign Prostatic Hyperplasia

Ginn

Tart

Sharkady

et al. 2018

Case Reports in Infectious Diseases

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Cedecea neteri, a member of the Enterobacteriaceae family, has only been identified as a human pathogen in a few previous clinical cases, thus complicating assessment of this organism's pathogenicity and medical relevance. Documented infections attributed to C. neteri primarily involved bacteremia in severely immunocompromised patients. We report a rare case of urinary catheter colonization by a multidrug-resistant C. neteri strain in a patient of advanced age with benign prostatic hyperplasia and other chronic comorbidities. This C. neteri isolate was resistant or intermediate to second-generation cephalosporins, penicillins, and certain β-lactamase inhibitor/β-lactam combinations. Analysis of whole genome sequence information for a representative C. neteri strain indicated the presence of multiple open reading frames with sequence similarity to β-lactamases, including a chromosome-encoded AmpC β-lactamase and metallo-β-lactamases, consistent with the resistance phenotype of this bacterium. The presence of an AmpR homolog suggests that the C. neteriampC may be inducible in response to β-lactam exposure. Molecular insights into antibiotic resistance traits of this emerging opportunistic pathogen will be important for administering adequate antibiotic treatment to ensure favorable patient outcomes.

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First reported case of pneumonia caused by Cedecea lapagei in America

Cited by 15 publications

References 11 publications

İleri Evre Orofarenks Kanserli Bir Hastada Nekroze Enfekte Tümöral Kitlede Cedecea Lapagei Süperenfeksiyonu: Olgu Sunumu (Cedecea lapagei süperenfeksiyonu)

İleri Evre Orofarenks Kanserli Bir Hastada Nekroze Enfekte Tümöral Kitlede Cedecea Lapagei Süperenfeksiyonu: Olgu Sunumu (Cedecea lapagei süperenfeksiyonu)

Expanding spectrum of opportunistic Cedecea infections: Current clinical status and multidrug resistance

Urinary Catheter Colonization by Multidrug-ResistantCedecea neteriin Patient with Benign Prostatic Hyperplasia

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