Occurrence of hepatitis B virus genotype B and B+C mixed infections in Chennai, South India

Koli, Suneeta; Radhakrishnan, Anand N. P.; Jacob, Melvin; Selvaraj, Vijayanandraj; Purushothaman, Girish Kumar Chethrapilly

doi:10.1016/j.bjid.2013.03.002

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“…The HBV genotype landscape in India, with its multiethnic population, is likely to be diverse. Many reports from India have documented HBV genotypes in infected individuals in specific regions of the country [61][62][63][64][65][66][67][68][69][70][71][72]. In this context, a pan-Indian study on the regional variations in HBV genotypes in this issue of the Journal is laudable [73].…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B genotyping: The utility for the clinicians

Fletcher

Eapen

Abraham

2019

Indian J Gastroenterol

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Section: Discussionmentioning

confidence: 99%

Hepatitis B genotyping: The utility for the clinicians

Fletcher

Eapen

Abraham

2019

Indian J Gastroenterol

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Genotyping of hepatitis B virus isolates from Lahaul and Spiti district in Himachal Pradesh, India

Sharma¹,

Katiyar²,

Barall³

et al. 2018

Indian J Gastroenterol

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Hepatitis B virus (HBV) has several genotypes. In the Indian population, genotypes A and D are the most frequent. HBV infection is hyper-endemic in the Lahaul and Spiti district in Himachal Pradesh; however, the virus genotype in this area is not known. We sequenced a 398-nucleotide segment of HBV genome that included parts of pre-S1/S2 and polymerase genes from 17 specimens from this district, and assigned a viral genotype to these. Of the 17 specimens studied, 13 (76% [95% confidence interval = 50-92%]) showed the presence of genotype C HBV; the remaining four were genotype D (n = 4; 24%) HBV. Prevalence of genotype C HBV was much higher in the district than in other parts of India. This may reflect the historical mixing of this population with that in China. Since genotype C has a higher risk of chronicity and mother-to-child transmission, prevention of HBV infection may need particular emphasis in this area.

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