Antimicrobial susceptibility associated with bloodstream infections in children: a referral hospital-based study

Ashtiani, Mohammad Taghi Haghi; Mamishi, Setareh; Masoomi, Ahmad; Nasiri, Nafiseh; Hosseini, Mona; Nikmanesh, Bahram; Pourakbari, Babak; Rezaei, Nima

doi:10.1016/j.bjid.2013.01.011

Cited by 9 publications

(11 citation statements)

References 4 publications

(4 reference statements)

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“…A. baumannii strains were sensitive to colistin and ampicillin-sulbactam. The resistance rate of P. aeruginosa in the current study, compared to the previous reports in the Children’s Medical Center,13,14,21 was substantially lower and showed quite high sensitivity to the tested common antibiotics. The K. pneumoniae strains depicted high resistance rate to cefotaxime (96.5%), which was compatible with the results reported by Molana et al (90%) 22.…”

Section: Discussioncontrasting

confidence: 70%

<p>Antibiotic resistance and genotyping of gram-negative bacteria causing hospital-acquired infection in patients referred to Children’s Medical Center</p>

Mamishi¹,

Mahmoudi²,

Naserzadeh³

et al. 2019

IDR

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Background and aimHospital-acquired infection (HAI) is a major problem worldwide. Understanding patterns of bacterial etiology and antibiotic susceptibility is vital to combating HAI. Besides, typing of isolates is important to establish the intra-hospital surveillance of resistant clones. In this study, we aimed to evaluate antibiotic resistance and genotyping of a number of gram-negative bacteria (GNB) causing HAI in patients who were referred to Children’s Medical Center.MethodsDuring the 6-month period, antimicrobial susceptibility profiles of GNB isolates recovered from patients in Children’s Medical Center were determined. Typing of common GNB was performed by random amplified polymorphic DNA (RAPD) analysis and the results were analyzed by Gelcompar II software.ResultsIn total, 142 (1.1%) gram-negative bacterial strains were isolated, among which 59.2% were from males. The most organisms were isolated from blood (63%) followed by wounds (13.7%). The greatest proportion of strains came from intensive care units (51%). Low sensitivity of Acinetobacter baumannii to common antibiotics and high resistance of Enterobacter spp. To cefotaxime (100%) were reported. The most efficient antibiotics for Escherichia coli strains were amikacin (84%) and gentamycin (81%). However, just 12.5% of Serratia marcescens strains were resistant to trimethoprim-sulfamethoxazole. The analysis of RAPD-typing revealed the presence of one clone in A. baumannii and E. coli and two clones in Klebsiella pneumoniae, whereas the trend varied completely in Pseudomonas aeruginosa strains and Enterobacter spp.ConclusionThe results of this study showed a possibility of an outbreak in the Children’s Medical Center. Since there is a possibility of transmission of an infection from one patient to another, high attention should be paid to the basic methods of preventing infection.

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Section: Discussioncontrasting

confidence: 70%

<p>Antibiotic resistance and genotyping of gram-negative bacteria causing hospital-acquired infection in patients referred to Children’s Medical Center</p>

Mamishi¹,

Mahmoudi²,

Naserzadeh³

et al. 2019

IDR

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“…In agreement with previous report, our data shows that the prevalence of gram-negative bacteria 81.97% in different clinical infections was higher than grampositive bacteria 18.03% (25). Culture based diagnosis of bacterial infections in a previous study showed that urinary tract infection was more prevalent than other infections.…”

Section: Discussionsupporting

confidence: 93%

Antibiotic resistance pattern of bacteria isolated from outdoor patients in Dhaka city: a single center study

2020

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Bacterial infections are often found to cause morbidity and mortality around the globe. Indiscriminate use of antibiotic for treatment of such infections is reported to cause selective pressure and increase in drug resistance. Emergence of antibiotic resistance is a growing concern for people of all age having bacterial infections. It is important to determine the trend of antibiotic resistance patterns of pathogenic bacteria isolated from clinical samples for appropriate treatment of patients. A retrospective study was conducted on patient samples collected from 1 July 2018 to 15 March 2019. A total of 500 urine, 136 blood, 120 stool, 172 swab, 90 Sputum and 60 pus samples were randomly collected from both male and female patients of different age groups who reported to a diagnostic centre in Dhaka city. Pathogenic bacteria were isolated and identified from the collected samples following standard methods. Antibiotic sensitivity patterns of isolated bacteria were also determined by disc diffusion test. Proportion of UTI in female patients (71.67%) was found to be higher than the male (28.33%) patients and mostly caused by Escherichia coli (73.33%). Among Gram negative bacteria, E. coli (51%) was found to be predominant followed by Pseudomonas spp. (11.47%), Klebsiella (9.84%) and Salmonella Typhi (9.84%). Among Gram positive organism Staphylococcus aureus (9.0%), beta haemolytic streptococci (5.74%) and enterococci (3.28%) were found to be present. Among the tested antibiotics imipenem was found to be the most effective (93.02%) followed by gentamycin (76.03%) against all isolated bacteria. Amoxycillin was found to be least effective (21.29%) against all isolated bacteria. Increase in antibiotic resistance was possibly due to indiscriminate use of antibiotic for treatment of various infections. Prudent use of antimicrobial drugs will help reduce spread of resistant bacteria and complication of treatment of infected patients. Stamford Journal of Microbiology, Vol.9(1) 2019: 1-4

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“…(Garg and Garg, 2017). These findings in our study for gram positive bacterial pathogens was also consistent with the reports of Ashtiani et al, from Iran and Karunakaran et al, from Malaysia (Karunakaran et al, 2007;Haghi Ashtiani et al, 2013). However, Most Western literature and few Indian studies suggests that CoNS account for 25%-57% of the cases of BSI, clinical significance of the CoNS isolated was not defined in these studies and may have resulted in an overestimation of prevalence.…”

Section: Antimicrobial Susceptibility Profile Of Gram Positive Isolatessupporting

confidence: 89%

Antimicrobial Susceptibility Profile from Patients with Blood Stream Infections at a Tertiary Care Level Super Speciality Institute in Northern India

Sen¹,

Singh²,

Kumar³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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Antimicrobial susceptibility associated with bloodstream infections in children: a referral hospital-based study

Cited by 9 publications

References 4 publications

<p>Antibiotic resistance and genotyping of gram-negative bacteria causing hospital-acquired infection in patients referred to Children’s Medical Center</p>

<p>Antibiotic resistance and genotyping of gram-negative bacteria causing hospital-acquired infection in patients referred to Children’s Medical Center</p>

Antibiotic resistance pattern of bacteria isolated from outdoor patients in Dhaka city: a single center study

Antimicrobial Susceptibility Profile from Patients with Blood Stream Infections at a Tertiary Care Level Super Speciality Institute in Northern India

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