Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells

Shi, Weifeng; Hou, Xueling; Li, Xiang; Peng, Hongjun; Jiang, Qingbo; Liu, Xiping; Ji, Yun; Yao, Yuhua; He, Caizhen; Lei, Xiang-Dong

doi:10.1016/j.bjid.2012.11.009

Cited by 30 publications

(20 citation statements)

References 39 publications

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“…As reported previously, EV71 infection induced apoptosis in both caspase-dependent and caspase-independent manners (Chang et al, 2004;Chen et al, 2007;Liang et al, 2004;Lu et al, 2013;Shi et al, 2013). To determine whether PDTC could influence the apoptosis-inducing property of EV71, cells were infected with EV71 (1.5 × 10 6 TCID50) and cultured in the medium containing various concentrations of PDTC for 7 h. Apoptotic cells were determined by flow cytometry through measuring the exposed phosphotidylserine.…”

Section: Pdtc Inhibits Apoptosis Induced By Ev71 Infectionmentioning

confidence: 89%

Pyrrolidine dithiocarbamate inhibits enterovirus 71 replication by down-regulating ubiquitin–proteasome system

Lin

Qin

et al. 2015

Virus Research

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Section: Pdtc Inhibits Apoptosis Induced By Ev71 Infectionmentioning

confidence: 89%

Pyrrolidine dithiocarbamate inhibits enterovirus 71 replication by down-regulating ubiquitin–proteasome system

Lin

Qin

et al. 2015

Virus Research

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“…MAPKs are key signaling molecules in innate immunity, which are widely conserved in eukaryotes and play an important role in response to many viral infections. The activation of MAPK signaling leads to the expression of cytokines or affects the growth of viruses [35]. Many RNA virus infections have shown differential expression of MAPK signaling pathway viz.…”

Section: Discussionmentioning

confidence: 99%

“…Many RNA virus infections have shown differential expression of MAPK signaling pathway viz. enterovirus 71 [35], [36]. Also, the JAK/STAT pathway has also been shown to contribute to anti-viral immunity [37].…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis reveals common differential and global gene expression profiles in bluetongue virus serotype 16 (BTV-16) infected peripheral blood mononuclear cells (PBMCs) in sheep and goats

et al. 2017

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Bluetongue is an economically important infectious, arthropod borne viral disease of domestic and wild ruminants, caused by Bluetongue virus (BTV). Sheep are considered the most susceptible hosts, while cattle, buffalo and goats serve as reservoirs. The viral pathogenesis of BTV resulting in presence or absence of clinical disease among different hosts is not clearly understood. In the present study, transcriptome of sheep and goats peripheral blood mononuclear cells infected with BTV-16 was explored. The differentially expressed genes (DEGs) identified were found to be significantly enriched for immune system processes - NFκB signaling, MAPK signaling, Ras signaling, NOD signaling, RIG signaling, TNF signaling, TLR signaling, JAK-STAT signaling and VEGF signaling pathways. Greater numbers of DEGs were found to be involved in immune system processes in goats than in sheep. Interestingly, the DEHC (differentially expressed highly connected) gene network was found to be dense in goats than in sheep. Majority of the DEHC genes in the network were upregulated in goats but down-regulated in sheep. The network of differentially expressed immune genes with the other genes further confirmed these findings. Interferon stimulated genes - IFIT1 (ISG56), IFIT2 (ISG54) and IFIT3 (ISG60) responsible for antiviral state in the host were found to be upregulated in both the species. STAT2 was the TF commonly identified to co-regulate the DEGs, with its network showing genes that are downregulated in sheep but upregulated in goats. The genes dysregulated and the networks perturbed in the present study indicate host variability with a positive shift in immune response to BTV in goats than in sheep.

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“…The information in MAPK pathway is transmitted via protein-protein interactions. By phosphorylating serine and threonine residues in diverse groups of proteins, MAPKs convert a variety of extracellular signals into a multitude of cellular responses (Ceballos-Olvera et al, 2010;Shi et al, 2013).…”

Section: Mapk Signalingmentioning

confidence: 99%

Role of MAPK/MNK1 signaling in virus replication

et al. 2018

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Viruses are obligate intracellular parasites; they heavily depend on the host cell machinery to effectively replicate and produce new progeny virus particles. Following viral infection, diverse cell signaling pathways are initiated by the cells, with the major goal of establishing an antiviral state. However, viruses have been shown to exploit cellular signaling pathways for their own effective replication. Genome-wide siRNA screens have also identified numerous host factors that either support (proviral) or inhibit (antiviral) virus replication. Some of the host factors might be dispensable for the host but may be critical for virus replication; therefore such cellular factors may serve as targets for development of antiviral therapeutics. Mitogen activated protein kinase (MAPK) is a major cell signaling pathway that is known to be activated by diverse group of viruses. MAPK interacting kinase 1 (MNK1) has been shown to regulate both cap-dependent and internal ribosomal entry sites (IRES)-mediated mRNA translation. In this review we have discuss the role of MAPK in virus replication, particularly the role of MNK1 in replication and translation of viral genome.

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Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells

Abstract: EV71 infection induces the differential gene expressions of MAPK signaling pathway such as ERK, JNK and PI3K/AKT in RD cells, which may be associated with the secretions of inflammatory cytokines and host cell apoptosis.

Cited by 30 publications

References 39 publications

Pyrrolidine dithiocarbamate inhibits enterovirus 71 replication by down-regulating ubiquitin–proteasome system

Pyrrolidine dithiocarbamate inhibits enterovirus 71 replication by down-regulating ubiquitin–proteasome system

Transcriptome analysis reveals common differential and global gene expression profiles in bluetongue virus serotype 16 (BTV-16) infected peripheral blood mononuclear cells (PBMCs) in sheep and goats

Role of MAPK/MNK1 signaling in virus replication

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