Etiologic and epidemiologic analysis of hand, foot, and mouth disease in Guangzhou city: a review of 4,753 cases

Zou, Xiao-ni; Zhang, Xiaozhuang; Wang, Bo; Qiu, Yi-teng

doi:10.1016/j.bjid.2012.08.001

Cited by 65 publications

(65 citation statements)

References 15 publications

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“…Çoğu olgu yaz süresince ve erken sonbahar dönemlerinde oluşur 3 . EAAH'nin çeşitli çalışmalarda ay dağılımı Tablo 3'de gösterildi 4,[7][8][9]15,16 . Çalışmamızda literatürle uyumlu olarak, hastalığın sonbahar ve yaz aylarında, yılda iki kez pik yaptığı gözlenmiştir.…”

Section: Gereç Ve Yöntemunclassified

“…Lezyonlar hastaların %94,9'unda ellerde, %87,2'sinde ayaklarda ve %61,5'inde kol, bacak ve/veya gluteal bölgelerde gözlendi. Bu sonuçlar, yurtdışından ve ülkemizden yapılan çalışmalar ile uyumlu idi 4,[6][7][8][9][14][15][16][17][18] . EAAH tanısı için genellikle klinik bulgular yeterlidir, kuşkulu durumlarda virüsün saptanmasıyla tanı kesinleştirilebilir 4 .…”

Section: Gereç Ve Yöntemunclassified

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Joint diagnosis of pediatric and dermatology clinics: Prospective observation of thirtynine patients with hand, foot and mouth disease

Bucak¹,

Tepe²,

Almış³

et al. 2017

TURKDERM

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Background and Design: Hand, foot and mouth disease (HFMD) is a childhood enteroviral eruptive disease presenting with fever and cutaneous and mucosal lesions. It is benign and generally resolves spontaneously, but may sometimes result in systemic involvement. The purpose of this study was to share our clinical experience concerning patients who were followed with the diagnosis of HFMD established by the pediatric and dermatology clinics. Materials and Methods: We prospectively evaluated patients who attended our hospital with the complaints of fever and eruptions and received the diagnosis of HFMD based on the clinical findings between December 2014 and November 2015. Age, sex, month of presentation, presentation symptoms and duration of symptoms were investigated. Systemic and dermatological examination findings, laboratory results and tests such as echocardiography were reviewed. Results: Thirty-nine patients were included; 19 (48.8%) were girl and 20 (51.2%) were boy. The mean age of the patients was 29.8±27.9 (6-155) months. Six (15.3%) patients were in the 0-12 month age group, while only 3 (7.8%) were older than 60 months. Presentations were most common in September, June and October. The most common presentation symptoms were eruptions on the hands and feet (100%), fever (82.1%) and oral aphthae (79.5%). The lesions were most commonly observed on the hands (94.9%, n=37) and feet (87.2%, n=34) and in the mouth (79.5%, n=31). Cardiac involvement was determined in 3 (7.7%) patients. Nail changes were observed during monitoring in 10 (25.6%) patients. AbstractAmaç: El-ayak-ağız hastalığı (EAAH); ateş, deri ve mukoza lezyonları ile seyreden, çocukluk çağının enteroviral döküntülü bir hastalığıdır. İyi seyirli ve kendiliğinden düzelme eğiliminde olmakla birlikte, nadiren sistemik tutuluma yol açabilir. Bu çalışmanın amacı, pediatri ve dermatoloji klinikleri tarafından EAAH tanısıyla takip edilen hastalara ait klinik deneyimlerimizi paylaşmaktır. Gereç ve Yöntem: Hastanemize Aralık 2014-Kasım 2015 tarihleri arasında ateş ve döküntü şikayeti ile başvuran hastalardan, klinik bulgulara dayanılarak EAAH tanısı koyulan hastalar prospektif olarak değerlendirildi. Hastaların yaşı, cinsiyeti, başvuru ayı, başvuru şikayeti ve süresi sorgulandı. Sistemik ve dermatolojik muayene bulguları, laboratuvar sonuçları, ekokardiyografi gibi ek inceleme tetkikleri gözden geçirildi. Bulgular: Çalışmaya toplam 39 hasta dahil edildi. Hastaların 19'u (%48,8) kız, 20'si (%51,2) erkek idi. Hastaların ortalama yaşı 29,8±27,9 (6-155) ay olarak hesaplandı. Yaş aralığına göre hastaların 6'sı (%15,3) 0-12 ay arasında iken, sadece 3'ü (%7,8) 60 aydan büyüktü. Başvurular en sık Eylül, Haziran ve Ekim aylarında görüldü. En sık başvuru şikayeti; el ve ayaklarda döküntü (%100), ateş (%82,1) ve oral aft (%79,5) idi. Lezyonlar, en sık el (%94,9, n=37), ayak (%87,2, n=34) ve ağız içinde (%79,5, n=31) görüldü. Üç hastada (%7,7) kardiyak tutulum saptandı. Takiplerde 10 hastada (%25,6) tırnak değişikliği gelişti. Sonuç: Çalışmamız sonucunda ülkemizde E...

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Section: Gereç Ve Yöntemunclassified

Joint diagnosis of pediatric and dermatology clinics: Prospective observation of thirtynine patients with hand, foot and mouth disease

Bucak¹,

Tepe²,

Almış³

et al. 2017

TURKDERM

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show abstract

“…12,[32][33][34][35] The leading pathogen causing HFMD in Beijing in 2007 was CA16 (75%), though this changed to EV71 in 2008 and 2009 (56% and 36%). 15 In Guangzhou in 2008, the predominant pathogen inducing HFMD was EV71 (48.24%); in 2009 this became CA16 (59.26%), and was EV71 again in 2010 (42.28%) 3 ( Table 1). Co-circulation of CA16 and EV71 has increased the possibility of co-infections and viral genetic recombination, which make it difficult to control HFMD epidemics.…”

Section: Hfmd Outbreaks Caused By Ca16mentioning

confidence: 99%

“…P1 can be processed by a virus-encoded proteinase, which results in viral capsid subunit proteins VP0, VP1, and VP3. 2,3 VP0 can be cleaved further to yield VP2 and VP4. VP1, VP2, and VP3 lie on the outer part of the capsid while VP4 is situated on the inner part.…”

Section: Introductionmentioning

confidence: 99%

“…14 In Mainland China, CA16 was the predominant pathogen causing HFMD in 2007 in Beijing 15 and in 2009 in Guangzhou. 3 Severe and fatal cases of HFMD have been mainly caused by EV71 infection; thus, studies have focused on EV71. Phase III clinical trials of EV71 inactivated vaccines have been completed, confirming their safety and protective effects.…”

Section: Introductionmentioning

confidence: 99%

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Coxsackievirus A16

Mao

Wang²,

Yao³

et al. 2013

Human Vaccines & Immunotherapeutics

139

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Epidemiologic and etiologic characteristics of hand, foot, and mouth disease in Chongqing, China between 2010 and 2013

Lai

Yan

et al. 2015

Journal of Medical Virology

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Hand, foot, and mouth disease (HFMD) has become very common in children, with widespread occurrence across China. The aim of this study was to investigate the epidemiologic and etiologic characteristics of HFMD, including etiologic variations in Chongqing, China. An epidemiologic investigation was based on 3,472 patients who presented with HFMD manifestations and were admitted at the Children's Hospital of Chongqing Medical University between 2010 and 2013. Fecal specimens from 830 patients were analyzed by nested RT-PCR to identify the enterovirus pathogens, and the molecular characterization of HFMD was illustrated by phylogenetic tree analysis. The results of this study indicate that the peak of the HFMD epidemic in Chongqing between 2010 and 2013 occurred between April and July each year. The median age of onset was 2.24 years old, and children under the age of five accounted for 96.4% of all the HFMD cases; the male-to-female ratio was 1.89:1. Enterovirus 71 accounted for a major proportion of the isolated strains every year, including the majority (74%) of severe cases. However, the proportion of Coxsackie A (CV-A) 6 infections increased from 2.11% in 2010 to 16.36% in 2013, while the proportion of CV-A16 infections decreased from 31.23% in 2010 to 4.67% in 2013. Molecular epidemiologic study showed that all enterovirus 71 strains belonged to subgenotype C4a, whereas all CV-A16 strains belonged to genotype B1, including subgenotype B1a and subgenotype B1b.

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Etiologic and epidemiologic analysis of hand, foot, and mouth disease in Guangzhou city: a review of 4,753 cases

Abstract: Seasonal fluctuations and HEV71 and CA16 were the two key factors influencing the Guangzhou HFMD epidemic. The infection predominantly affected children younger than 5 years old.

Cited by 65 publications

References 15 publications

Joint diagnosis of pediatric and dermatology clinics: Prospective observation of thirtynine patients with hand, foot and mouth disease

Joint diagnosis of pediatric and dermatology clinics: Prospective observation of thirtynine patients with hand, foot and mouth disease

Coxsackievirus A16

Epidemiologic and etiologic characteristics of hand, foot, and mouth disease in Chongqing, China between 2010 and 2013

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