Hantavirus infection in HIV positive individuals in Rio de Janeiro, Brazil: a seroprevalence study

Lamas, Cristiane da Cruz; Oliveira, Renata Carvalho de; Silva, Raphael Gomes da; Vicente, Luciana Helena Bassan; Almeida, Elza; Lemos, Elba Regina Sampaio de; Bóia, Márcio Neves

doi:10.1016/j.bjid.2012.07.018

Cited by 1 publication

(1 citation statement)

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“…Studies conducted to clarify doubts in the diagnosis of febrile disease of unknown etiology point to the need for immediate laboratory confirmation during outbreak/epidemic situations, as the many clinical manifestations may not characterize the diseases [48,49]. Serologic evidence of hantavirus has been identified in patients with clinical suspicion of dengue, malaria, influenza, chikungunya, rickettsial infections, leptospirosis, and HIV [50,51,52,53,54,55,56,57,58,59]. Thus, the results of this study in which the initial diagnosis was malaria and dengue, reinforce the need for an alert to health professionals working in endemic areas of malaria regarding the importance to investigate the hantavirus infection, as here performed with the population from Colniza.…”

Section: Discussionmentioning

confidence: 99%

Malaria and Hantavirus Pulmonary Syndrome in Gold Mining in the Amazon Region, Brazil

Terças-Trettel

Oliveira²,

Fontes

et al. 2019

IJERPH

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People living in mining regions are exposed to numerous biological agents by several specific types of transmission mechanisms. This study is designed to describe fatal hantavirus pulmonary syndrome (HPS) cases confirmed by serology and molecular analysis, where a seroprevalence survey was conducted in the gold mining regions of the state of Mato Grosso, in the official Amazon region, Brazil. Two fatal cases of HPS were confirmed in a mining area in the Legal Amazon, where malaria is one of the most important public health problems. A molecular analysis detected the presence of the genome of the Castelo dos Sonhos virus. Out of the 112 blood samples analyzed, five were positive for Plasmodium infection (four P. falciparum and one P. vivax), and four were seropositive for hantavirus, showing a seroprevalence of 3.57%. One of the four miners who was seroreactive for hantavirus concomitantly had P. falciparum infection, which was confirmed by thick blood smear. This manuscript highlights the importance of considering hantavirus pulmonary syndrome as a diagnostic possibility in febrile infection associated with pulmonary manifestations in mining areas where malaria cases are often identified.

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