Infective endocarditis on a percoutaneous prosthetic aortic valve with associated glomerulopathy due to Granulicatella adjacens

Quiroga, Borja; Arroyo, David; Verde, Eduardo; Eworo, Alia; Luño, José

doi:10.1016/j.bjid.2012.07.011

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…In 2 cases, only criteria for "possible" PVE were achieved, but given the high suspicion, they were finally included in the present review (7,8). Fever (80%) and heart failure (22%) were the most common initial symptoms of PVE in the TVR population.…”

Section: Resultsmentioning

confidence: 99%

Prosthetic Valve Endocarditis After Transcatheter Valve Replacement

Amat‐Santos

Ribeiro

Ureña

et al. 2015

JACC: Cardiovascular Interventions

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Section: Resultsmentioning

confidence: 99%

Prosthetic Valve Endocarditis After Transcatheter Valve Replacement

Amat‐Santos

Ribeiro

Ureña

et al. 2015

JACC: Cardiovascular Interventions

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“…Literatures report that outcome with infective endocarditis caused G species had been associated with adverse consequences (5). Our patient is fortunate enough to survive the condition and now currently stable while waiting for mitral valve replacement surgery.…”

Section: Discussionmentioning

confidence: 73%

Granulicatella adiacens, the Elusive Endocarditis Causative Agent: Highlighting the Challenges Faced by Microbiology Laboratory

Sahlan¹,

Rustam²

2023

MJMHS

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A 58-year-old man with history of mitral valve prolapse and previous motor vehicle accident presented with one week history of lower back pain and fever. He was initially treated for pyelonephritis and given ceftriaxone. Blood culture grew Granulicatella adiacens after 7 days of incubation. The laboratory then referred the case to infectious disease team in view of possible infective endocarditis. Urgent echocardiogram was done and confirmed the diagnosis. His antibiotic was changed to intravenous benzylpenicillin and gentamicin. Granulicatella adiacens are difficult to be isolated in the laboratory hence they imposed certain challenges in laboratory identification. Most patients with Granulicatella adiacens infective endocarditis present with non-specific symptoms, imposing further challenge in recognizing the condition. These factors posed significant challenges in diagnosing Granulicatella adiacens endocarditis. This case highlighted challenges faced by the laboratories and the need of high index of clinical suspicion and prompt communication to ensure optimum patient care and management.

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“…), are thought to account for 2% of all infective endocarditis cases [12]. Due to difficulties in obtaining positive microbiology cultures, Granulicatella adjacens is known to be responsible for culture-negative infective endocarditis [13]. Both methods used in this evaluation were convergent for Abiotrophia spp, and one Granulicatella case, but divergent for 2 other cases of Granulicatella.…”

Section: Discussionmentioning

confidence: 94%

Proof of Concept Evaluation of a New Diagnostic POCT Device for Culture- Independent Microbiological Diagnosis of Infective Endocarditis

Karrasch¹,

Pfister²,

Diab³

et al. 2019

Arch Clin Microbiol

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Introduction: Accurate and fast microbiological diagnosis of infective endocarditis (IE) is of vital importance for patient outcome.Material & Methods: Forty culture-negative heart valves were evaluated with a new POCT multiplex-PCR cartridge (Unyvero ™ , Curetis AG, Holzgerlingen, Germany), advertised to detect several Gram positive/negative bacteria and fungi, together with several antibiotic resistance genes. Those POCT results were compared to conventional 16S rDNA PCR/sequencing results. Results: POCT multiplex-PCR was positive in 13 cases [Staphylococcus aureus (n=5), Enterococcus spp. / E. faecalis (n=5), ConS (n=1), Granulicatella adjacens (n=1), Abiotrophia adjacens (n=1)]. Antibiotic resistances were found in 44 specimens, from which 2 specimens were without any pathogen identification. 16S rDNA PCR was positive in 20 cases. Consecutive sequencing identified those as Staphylococcus spp. (n=6), Enterococcus faecalis (n=4), Streptococcus spp. (n=4), Leifsonia shinshuensis (n=1),Granulicatella elegans / G. adjacens (n=2), Abiotrophia adjacens (n=1). One case was positive in 16S PCR without any reliable signal in sequencing. When comparing both methods, identification was consistent in 9 cases and divergent in other 9 cases. Discussion: This POCT cartridge is easy to integrate into the daily microbiology laboratory work flow, and is less laborious than 16S sequencing PCR. For the application in routine IE diagnosis, the system needs to be optimized to include targets for viridans streptococci and HACEK group. In addition, problems with invalid resistance and pathogen target detection need to be fixed by the producer. Conclusion:The analyzed POCT system might be a future diagnostic tool for IE detection following assay optimization.

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Infective endocarditis on a percoutaneous prosthetic aortic valve with associated glomerulopathy due to Granulicatella adjacens

Cited by 6 publications

References 6 publications

Prosthetic Valve Endocarditis After Transcatheter Valve Replacement

Prosthetic Valve Endocarditis After Transcatheter Valve Replacement

Granulicatella adiacens, the Elusive Endocarditis Causative Agent: Highlighting the Challenges Faced by Microbiology Laboratory

Proof of Concept Evaluation of a New Diagnostic POCT Device for Culture- Independent Microbiological Diagnosis of Infective Endocarditis

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