Mycobacterium tuberculosis meningitis as the first presentation of chronic granulomatous disease

Khotaei, Ghamar Taj; Hirbod-Mobarakeh, Armin; Amirkashani, Davoud; Manafi, Farzad; Rezaei, Nima

doi:10.1016/j.bjid.2012.06.024

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…11 In a review of the literature, Deffert et al 12 reported a total of 297 cases of mycobacterial infections in patients with CGD. [13][14][15][16][17][18][19][20][21][22][23][24] BCG disease has been reported in 220 (74%) patients with CGD. 11 Similarly, tuberculosis has been reported in 59 (20%) patients.…”

mentioning

confidence: 99%

Mycobacterial disease in patients with chronic granulomatous disease: A retrospective analysis of 71 cases

Conti

Reyes

Galicia

et al. 2016

Journal of Allergy and Clinical Immunology

118

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mentioning

confidence: 99%

Mycobacterial disease in patients with chronic granulomatous disease: A retrospective analysis of 71 cases

Conti

Reyes

Galicia

et al. 2016

Journal of Allergy and Clinical Immunology

118

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“…[29][30][31][32][33][34][35][36][37][38] Several cases have described CNS infections complicated by obstructive hydrocephalus in CGD pediatric patients, 33,[39][40][41]45 but we found only one other report in the literature of obstructive hydrocephalus in an adult CGD patient. 16 Other previously described cases of CNS infection in CGD patients involve tuberculosis, 41 Salmonella, 42,43 Phaeoacremonium parasiticum, 44 Alternaria infectoria, 45 and Scedosporium prolificans. …”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Combination Therapies for Smoking Cessation

Nhan¹,

Windle²,

Eisenberg³

et al. 2015

CJGIM

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“…NADPH oxidase is an important component of human immunological defense against mycobacterial infection, and reduced ROS-induced killing increases the survival of MTB. Soroush et al [41] first described in Iran a heterozygous carrier of CGD combined with MTB and NTM, whilst Khotaei et al [42] described a 3-year-old girl with a 3-week fever and chills who was diagnosed with tuberculous meningitis and CGD.…”

Section: Infections In Iranian Cgd Patientsmentioning

confidence: 99%

Common Infections and Target Organs Associated with Chronic Granulomatous Disease in Iran

Mortaz

Azempour

Mansouri

et al. 2019

Int Arch Allergy Immunol

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Recurrent severe bacterial and fungal infections are characteristic features of the rare genetic immunodeficiency disorder chronic granulomatous disease (CGD). The disease usually manifests within the first years of life with an incidence of 1 in approximately 200,000 live births. The incidence is higher in Iran and Morocco where it reaches 1.5 per 100,000 live births. Mutations have been described in the 5 subunits of NADPH oxidase, mostly in gp91^phox and p47^phox, with fewer mutations reported in p67^phox, p22^phox, and p40^phox. These mutations cause loss of superoxide production in phagocytic cells. CYBB, the gene encoding the large gp91^phox subunit of the transmembrane component cytochrome b₅₅₈ of the NADPH oxidase complex, is localized on the X-chromosome. Genetic defects in CYBB are responsible for the disease in the majority of male CGD patients. CGD is associated with the development of granulomatous reactions in the skin, lungs, bones, and lymph nodes, and chronic infections may be seen in the liver, gastrointestinal tract, brain, and eyes. There is usually a history of repeated infections, including inflammation of the lymph glands, skin infections, and pneumonia. There may also be a persistent runny nose, inflammation of the skin, and inflammation of the mucous membranes of the mouth. Gastrointestinal problems can also occur, including diarrhea, abdominal pain, and perianal abscesses. Infection of the bones, brain abscesses, obstruction of the genitourinary tract and/or gastrointestinal tract due to the formation of granulomatous tissue, and delayed growth are also symptomatic of CGD. The prevention of infectious complications in patients with CGD involves targeted prophylaxis against opportunistic microorganisms such as Staphylococcus aureus, Klebsiella spp., Salmonella spp. and Aspergillus spp. In this review, we provide an update on organ involvement and the association with specific isolated microorganisms in CGD patients.

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Mycobacterium tuberculosis meningitis as the first presentation of chronic granulomatous disease

Cited by 7 publications

References 5 publications

Mycobacterial disease in patients with chronic granulomatous disease: A retrospective analysis of 71 cases

Mycobacterial disease in patients with chronic granulomatous disease: A retrospective analysis of 71 cases

A Systematic Review of Combination Therapies for Smoking Cessation

Common Infections and Target Organs Associated with Chronic Granulomatous Disease in Iran

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