Breast cancer among human immunodeficiency virus (HIV)-infected patients: the experience in Brescia, Northern Italy

Calabresi, Alessandra; Ferraresi, Alice; Vavassori, Andrea; Castelli, Francesco

doi:10.1016/j.bjid.2012.06.001

Cited by 8 publications

(12 citation statements)

References 3 publications

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“…82 - 84 In the University of Maryland study, the median CD4 count was 437.5 cells/μL. 57 Similarly, a median CD4 count of 424 cells/μL was noted in an Italian cohort, 59 and 50% of South African patients with breast cancer and HIV had CD4 counts between 200 and 499 cells/μL. 3 A case report by García-Tejedor et al 85 of a patient with HIV and hepatitis C virus infection even documented a CD4 count as low as 181 cells/mL.…”

Section: Resultsmentioning

confidence: 93%

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Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship

Grover

Martei

Puri

et al. 2018

JGO

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IntroductionThe number and lifespan of individuals living with HIV have increased significantly with the scale-up of antiretroviral therapy. Furthermore, the incidence of breast cancer in women with HIV is growing, especially in sub-Saharan Africa (SSA). However, the association between HIV infection and breast cancer is not well understood.MethodsA literature search was performed to identify articles published in journals pertaining to breast cancer and HIV, with an emphasis on SSA. Selected US-based studies were also identified for comparison.ResultsAmong the 56 studies reviewed, the largest study examined 314 patients with breast cancer and HIV in the United States. There is no consensus on whether HIV infection acts as a pro-oncogenic or antioncogenic factor in breast cancer, and it may have no relation to breast cancer. A higher incidence of breast cancer is reported in high-income countries than in SSA, although breast cancer in SSA presents at a younger age and at a more advanced stage. Some studies show that patients with breast cancer and HIV experience worse chemotherapy toxicity than do patients without HIV. Data on treatment outcomes are limited. The largest study showed worse treatment outcomes in patients with HIV, compared with their counterparts without HIV.ConclusionHIV infection has not been associated with different clinical presentation of breast cancer. However, some evidence suggests that concurrent diagnosis of HIV with breast cancer is associated with increased therapy-related toxicity and worse outcomes. Systematic prospective studies are needed to establish whether there is a specific association between breast cancer and HIV.

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Section: Resultsmentioning

confidence: 93%

“… 79 Data from high-income countries’ cohorts suggest an earlier age at diagnosis in patients with HIV and breast cancer compared with their counterparts without HIV in several small inconclusive investigations. 57 , 59 …”

Section: Resultsmentioning

confidence: 99%

Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship

Grover

Martei

Puri

et al. 2018

JGO

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“…Case reports, case series and cohorts from the HIC and low-tomiddle- income countries (LMIC) have consistently demonstrated that BC occurs at a younger age in PLWHA. 3,41,53,73,74 A 2-year study at the Tygerberg Academic Hospital in Cape Town, South Africa, reported similar tendencies, with a median age at presentation of 54 years for patients without HIV compared with 42 years for patients with HIV (P=0.001). 75 This finding has been confirmed by other SSA studies.…”

Section: Clinical and Pathological Characteristics Of Bc In Plwhamentioning

confidence: 87%

Breast cancer, human immunodeficiency virus and highly active antiretroviral treatment; implications for a high-rate seropositive region

Chirkut¹

2019

Oncol Rev

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Sub-Saharan Africa is the region in the world with the most people infected with the human immunodeficiency virus (HIV). The incidence of breast cancer is also rising in the region. This transcript focusses on the burden of these two diseases when they converge in the same populace. This comprehensive literature review of the topic suggests a trend towards an increasing incidence of breast cancer in the HIV-infected population, and the rationale for such a tendency is hypothesized, especially in the context of the availability of highly active antiretroviral therapy. Besides the age at diagnosis, all other clinical characteristics appear to be similar in HIV-positive and HIV-negative breast cancer populations. Outcomes of the different treatment modalities for breast cancer in HIV-positive patients are also appraised and finally innovative areas of future research are suggested along with plausible recommendations.

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“…Only 33 % of our patients were older than 50 years compared to 79 % in the general population [27]. The occurrence of breast cancer in younger patients with HIV has been a common finding between reported case series [11][12][13]19]; however, a recent study reported that these differences disappear after adjusting for differences in the populations at risk of HIV patients [28]. Half of our patients had ER-positive breast cancer and 6 % were HER-2 overexpressing.…”

Section: Discussionmentioning

confidence: 85%

“…In 2001, we reported our experience with 20 patients with breast cancer and HIV and it was the largest cohort to that date [18]. Since then, even though there have been continuous reports, it still remains the report of small case series and a few series linking cancer to HIV registries [9,11,13,15,[19][20][21][22][23][24][25]. The recent report of 151 patients in Soweto, Africa [12] constitutes the largest cohort to date and they reported equal prevalence to the HIV-negative cohort; however, no information regarding treatment and outcome was given.…”

Section: Introductionmentioning

confidence: 99%

Clinical outcomes in breast cancer patients with HIV/AIDS: a retrospective study

Gomez

Montero

Hurley

2015

Breast Cancer Res Treat

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The purpose of the study is to describe what is the presentation of breast cancer in women with HIV, their tolerance to therapy, the most common complications of treatment and their outcomes. Retrospective chart review of patients with HIV diagnosed with breast cancer between January 1, 1989 and December 31, 2013 at the University of Miami/Jackson Memorial Hospital (UM/JMH) 47 females and 1 male were included in the analysis. The median age of diagnosis was 46 years (IQR 41-52) and 64% of the women were premenopausal. Median CD4(+) count was 330 cells/µL (IQR 131-589 cells/µL). 41% had AIDS at time of diagnosis. 94% of patients presented with locoregional disease and 6% with late stage breast cancer. 52% had ER(+) tumors. 6% had HER-2/neu tumor expression and 21 % had triple negative disease. The 5 year PFS was 50% (95% CI 34-64%), the 5 year OS was 44% (95% CI 29-58%), and the Breast cancer-specific survival was 57% (95% CI 40-70%). Death was attributed to breast cancer in 22 patients, AIDS progression in 6 patients, other medical condition in 1, and for 4, the cause was unknown. Serious adverse events were documented in 46% of patients treated with chemotherapy. Targeted therapy was well tolerated. Patients with HIV/AIDS and breast cancer pose a major challenge for oncologists. Surgery, radiation, and endocrine therapy are well tolerated. Standard dose chemotherapy can have life-threatening side effects which can be managed with growth factor support and antimicrobial prophylaxis. All cancer therapy can be given while continuing with antiviral therapy at full dose.

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Breast cancer among human immunodeficiency virus (HIV)-infected patients: the experience in Brescia, Northern Italy

Cited by 8 publications

References 3 publications

Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship

Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship

Breast cancer, human immunodeficiency virus and highly active antiretroviral treatment; implications for a high-rate seropositive region

Clinical outcomes in breast cancer patients with HIV/AIDS: a retrospective study

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