Evaluation of criteria of manual blood smear review following automated complete blood counts in a large university hospital

Comar, Samuel Ricardo; Malvezzi, Mariester; Pasqüini, Ricardo

doi:10.1016/j.bjhh.2017.06.007

Cited by 23 publications

(15 citation statements)

References 29 publications

(50 reference statements)

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“…Any positive smear ndings represent relevant clinical information that must be described in complete blood counts as per local consensus indicating the morphological changes and cell percentages relevant for the diagnosis and monitoring of patients [21].…”

Section: Discussionmentioning

confidence: 99%

Schistocytes Evaluation in Iron Deficiency: An Assessment Adopted From ICSH Nomenclature Guideline

Ratnaningsih¹,

Martani²,

Putri³

et al. 2020

Preprint

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Objective The diagnostic validity of schistocyte count in diagnosing iron deficiency in the microcytic population is critical to evaluate. The purpose of this study is to identify the correlation between schistocyte count and iron parameters, and the performance of schistocyte count in diagnosing iron deficiency in the microcytic population.Results Out of 805 general check-up participants, 65 subjects consisting of 17 males and 48 females aged 18–56 years had Mean Corpuscular Value (MCV) < 80 fL. Serum ferritin examination showed 25 patients with iron deficiency and the other 40 subjects without iron deficiency. There was a significant difference in the schistocyte count between the two groups (p < 0,001). Correlation analysis obtained a significant relationship between schistocyte count and serum ferritin (r=-0,67, p < 0,001). The Receiver Operating Characteristic (ROC) curve analysis provided Area Under the Curve (AUC) of schistocyte count is 0.827 with Youden Index (YI) 55% for a cut-off of ≥0.75%.

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Section: Discussionmentioning

confidence: 99%

Schistocytes Evaluation in Iron Deficiency: An Assessment Adopted From ICSH Nomenclature Guideline

Ratnaningsih¹,

Martani²,

Putri³

et al. 2020

Preprint

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“…The International Consensus Group for Haematology Review published in 2005 criteria for reviewing CBCs [3]. In general, adjustments are needed to account for local populations characteristics and laboratory resources [21,6,15,2]. While the manual technique is more effective identifying nuances in cell shapes, it incurs a substantial time and cost burden on laboratory staff.…”

Section: Introductionmentioning

confidence: 99%

Optimising Criteria for Manual Smear Review Following Automated Blood Count Analysis: A Machine Learning Approach

Avalos

Touchais

Henríquez-Henríquez

2021

Advances in Intelligent Systems and Computing

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The complete blood count (CBC) performed by automated haematology analysers is the most common clinical procedure in the world. Used for health checkup, diagnosis and patient follow-up, the CBC impacts the majority of medical decisions. If the analysis does not fit an expected setting, the laboratory staff manually reviews a blood smear, which is highly time-consuming. Criteria for reviewing CBCs are based on international consensus guidelines and locally adjusted to account for laboratory resources and populations characteristics. Our objective is to provide a clinical laboratory decision support tool to identify which CBC variables are linked to an increased risk of abnormal manual smear and at which threshold values. Thus, we treat criteria adjustment as a feature selection problem. We propose a cost-sensitive Lasso-penalised additive logistic regression combined with stability selection, adapted to the peculiarities of data and context: class-imbalance, categorisation of continuous predictors, required stability and enhanced interpretability. Using simulated and real CBC data, we show that our proposal is competitive in terms of predictive performance (compared to deep neural networks) and model selection performance (provided that there is sufficient data in the neighbourhood of the true thresholds). The R code is publicly available as an open source project.

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“…A manual blood smear review is defined as the thorough and careful microscopic analysis of a well-prepared and stained smear of the peripheral blood, with the objective of seeking morphological changes relevant to the diagnosis and monitoring of patients (1). Laboratory-initiated examinations of blood smears for patients with anemia are usually the result of a laboratory policy according to which a blood smear is ordered whenever the hemoglobin concentration is unexpectedly low.…”

Section: Introductionmentioning

confidence: 99%

And the Oscar goes to peripheral blood film for detection of lead poisoning in a complicated toxic patient: A case report with review of laboratory clues

Zamani

et al. 2021

Preprint

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Evaluation of criteria of manual blood smear review following automated complete blood counts in a large university hospital

Cited by 23 publications

References 29 publications

Schistocytes Evaluation in Iron Deficiency: An Assessment Adopted From ICSH Nomenclature Guideline

Schistocytes Evaluation in Iron Deficiency: An Assessment Adopted From ICSH Nomenclature Guideline

Optimising Criteria for Manual Smear Review Following Automated Blood Count Analysis: A Machine Learning Approach

And the Oscar goes to peripheral blood film for detection of lead poisoning in a complicated toxic patient: A case report with review of laboratory clues

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