Oral lesions associated with Fanconi anemia

Stoopler, Eric T.; Homeida, Lujain; Sollecito, Thomas P.

doi:10.1016/j.bjhh.2017.03.003

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…Some genetic syndromes that cause dysregulation of DNA metabolism of oral epithelium can lead to premalignant and malignant lesions in this region. Dyskeratosis congenita (Zinsser-Engman-Cole syndrome), Bloom syndrome (BS; congenital telangiectatic erythema), Xeroderma pigmentosum and Fanconi anemia show an increased incidence of OPMDs and OSCC [9,44].…”

Section: Other Risk Factorsmentioning

confidence: 99%

“…Moreover, chronic mucosal inflammation and oral mucosal trauma from teeth and prosthetic devices have received increasing attention in several clinical and scientific studies [5]. Other suggested factors in common between oral cancer and premalignant lesions are alteration of the microbiome, systemic sclerosis, genetic disease with dysregulation of DNA metabolism (Zinsser-Engman-Cole syndrome, Fanconi anemia and Xeroderma pigmantosum), hematinic and micronutrient deficiency [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies

Lorini

Bescós‐Atín

Thavaraj

et al. 2021

Cancers

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Oral squamous cell carcinoma (OSCC) is a very aggressive cancer, representing one of the most common malignancies worldwide. Oral potentially malignant disorders (OPMDs) regroup a variegate set of different histological lesions, characterized by the potential capacity to transform in OSCC. Most of the risk factors associated with OSCC are present also in OPMDs’ development; however, the molecular mechanisms and steps of malignant transformation are still unknown. Treatment of OSCC, including surgery, systemic therapy and radiotherapy (alone or in combination), has suffered a dramatic change in last years, especially with the introduction of immunotherapy. However, most cases are diagnosed during the advanced stage of the disease, decreasing drastically the survival rate of the patients. Hence, early diagnosis of premalignant conditions (OPMDs) is a priority in oral cancer, as well as a massive education about risk factors, the understanding of mechanisms involved in malignant progression and the development of specific and more efficient therapies. The aim of this article is to review epidemiological, clinical, morphological and molecular features of OPMDs, with the purpose to lay the foundation for an exhaustive comprehension of these lesions and their ability of malignant transformation and for the development of more effective and personalized treatments.

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Section: Other Risk Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies

Lorini

Bescós‐Atín

Thavaraj

et al. 2021

Cancers

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“…Fanconi anemia patients are at high risk for oral squamous cell carcinoma. 3 Clinical findings in FA are café au lait spots, short stature, hand abnormality, micrognathia, developmental delay, hyperpigmentation of the neck, cardiac malformation, and many others. Fanconi anemia requires a multidisciplinary follow-up so that appropriate clinical management of patients and their families is achieved.…”

Section: Oral Lesions Associated With Anemia Fanconi Anemiamentioning

confidence: 99%

Orofacial Manifestations associated with Anemia

Gupta¹,

Swarup²,

Sairam³

et al. 2017

World Journal of Anemia

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Oral cavity is the window to the body and is often the area where systemic disease first presents itself. The various tissues including lips, tongue, gingiva, mucosal surfaces, dentition, and bone are involved in the presentation of disease state. The most frequently affected is the periodontium, followed by the oral mucous membrane and the periapical inflammations. The review is not all inclusive; however, it does address some of the most common, as well as a few of the more rare anemia-associated disease states observed in both adults and children. How to cite this article Gupta S, Gupta S, Swarup N, Sairam H, Sinha N, Nair SS. Orofacial Manifestations associated with Anemia. World J Anemia 2017;1(2):44-47.

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Oral lesions associated with Fanconi anemia

Cited by 2 publications

References 3 publications

Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies

Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies

Orofacial Manifestations associated with Anemia

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