Gingival swelling associated with hypoplasminogenemia

Stoopler, Eric T.; Alawi, Faizan

doi:10.1016/j.bjhh.2016.04.006

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Although its role in intravascular and extravascular fibrinolysis is well defined, it also plays an important role as a proteolytic enzyme, degrading the proteins of the extracellular matrix, activating metalloproteases, and repairing wounds. Its deficit leads to an inability to lysis of fibrin, producing an accumulation of this protein, which is the cause of the clinically observed manifestations 5 …”

Section: Discussionmentioning

confidence: 99%

Congenital plasminogen deficiency with long standing pseudomembranous conjunctival and genital lesions

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Congenital plasminogen deficiency with long standing pseudomembranous conjunctival and genital lesions

et al. 2019

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“…As most of the hemostatic disorders, it is classified as type 1 (hypoplasminogenemia), due to low plasminogen antigen levels and activity, or type 2 (dysplasminogenemia), due to low plasminogen activity with normal antigen levels. 2 Severe PLGD, due to homozygous or compound heterozygous mutations of PLG gene leads to inadequate lysis of fibrin, causing accumulation of this protein, which is the cause of clinically observed membranous lesions in multiple systems, such as eyes, ears, respiratory tract, kidneys, female genital tract, and central nervous system. These lesions consist of fibrin, immunoglobulins, and infiltrations from eosinophils, granulocytes, and lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

Ligneous conjunctivitis associated with type I plasminogen deficiency: A rare case

Dimopoulos

Zacharioudakis

Kazamias

et al. 2021

European Journal of Ophthalmology

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Ligneous conjunctivitis is a rare form of chronic, recurrent conjunctivitis characterized by wood-like, fibrinous pseudomembranes, which may be associated with systemic disease manifestations. It has been associated with congenital plasminogen (PLG) deficiency that is inherited with an autosomal recessive pattern due to mutations in the PLG gene and a variety of other genes, leading to disturbed wound healing. In this case report, we present the clinical, laboratory, and histopathological findings of a 36-year-old female patient who presented at the ophthalmology department with complaints of redness, irritation for the previous few weeks, and appearance of membranous lesions mainly on the tarsal conjunctivae. During biomicroscopic examination we found thick, yellowish-white pseudomembranes, and conjunctival proliferation with ligneous induration on the conjunctiva, located on the upper eyelids. Histopathological evaluations showed up ligneous conjunctivitis and laboratory evaluation confirmed a severe plasminogen deficiency (PLG < 2%). The patient was treated with topical fresh frozen plasma (FFP), topical steroids, heparin eye drops, and artificial tear drops daily, without systemic therapy.

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Gingival swelling associated with hypoplasminogenemia

Cited by 2 publications

References 3 publications

Congenital plasminogen deficiency with long standing pseudomembranous conjunctival and genital lesions

Congenital plasminogen deficiency with long standing pseudomembranous conjunctival and genital lesions

Ligneous conjunctivitis associated with type I plasminogen deficiency: A rare case

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