Immune thrombocytopenia associated with pleural and pericardial tuberculosis: case report

Madaleno, João; Fernandes, António; Cochicho, Joana; Silva, Nuno; Carvalho, Armando

doi:10.1016/j.bjhh.2016.02.002

Cited by 3 publications

(2 citation statements)

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“…On the other hand, platelet variations, more specially thrombocytosis, are common observations in tuberculosis. Thrombocytopenia in TB was ascribed to a general context of pancytopenia, a form of immune thrombocytopenia or to effect of anti-tuberculosis antibiotics [43] [44] [45]. The range of variations of platelet count observed in this study is close to previous reports [6].…”

Section: Discussionsupporting

confidence: 84%

Anemia and Hematologic Characteristics in Newly Diagnosed Pulmonary Tuberculosis Patients at Diagnosis in Kinshasa

Mulenga¹,

Kayembe²,

Kabengele³

et al. 2017

JTR

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Context: The burden of TB in Africa tends to be exacerbated by the socio-economic situation and the high prevalence of intercurrent infections such as HIV, malaria and non-specific bacterial infections. These factors often result in anemia, making patients at high risk for anemia. Objective: We aimed to gain insights into the characteristics of anemia, hematologic variations and socio-economic status in untreated pulmonary TB patients (PTB) in Kinshasa, the Democratic Republic of Congo. Methods: We conducted a cross-sectional analysis of 200 smear-positive pulmonary TB patients (PTB) recruited at the initiation of TB treatment. Complete Blood Count, Iron profile, BMI, CRP and albuminemia were assessed. Data were analyzed using Student t or Mann Whitney tests as appropriate, and logistic regression was performed to assess the strength of associations. Results: Anemia was a regular finding in (69%). This anemia was mostly moderate (92.2%) and with iron deficiency pattern (48%). Hypoalbuminemia was observed in half of the subjects and appears to be correlated with the severity of anemia. Surprisingly, the severity of inflammation, as reflected by the CRP, was inversely correlated with the anemia. In the multivariate analysis, alcohol intake (OR: 2.38; IC 95%: 1.05 -5.38), hypoalbuminemia (OR: 1.98; IC 95%: 1.02 -3.82) and CRP rate were significantly associated with the presence of anemia among pulmonary tuberculosis at the diagnostic. Conclusion: This study demonstrates the heavy burden of the iron responsive anemia and risky life conditions in newly diagnosed TB patients, and underscores the potential usefulness of iron supplementation in the Congolese context.

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