2015
DOI: 10.1016/j.bjhh.2015.08.008
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Diagnostic approach to hemolytic anemias in the adult

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Cited by 5 publications
(3 citation statements)
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References 5 publications
(18 reference statements)
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“…There is a gap in the reliable diagnostic tests for determining the levels of free heme in biological samples. The severity of hemolysis and heme toxicity may currently be indirectly estimated by the Hp and Hx levels [ 14 , 19 ]. Thus, a practical and specific test is urgently needed to determine the labile heme in biological fluids and tissues.…”
Section: Discussionmentioning
confidence: 99%
“…There is a gap in the reliable diagnostic tests for determining the levels of free heme in biological samples. The severity of hemolysis and heme toxicity may currently be indirectly estimated by the Hp and Hx levels [ 14 , 19 ]. Thus, a practical and specific test is urgently needed to determine the labile heme in biological fluids and tissues.…”
Section: Discussionmentioning
confidence: 99%
“…There is a gap in reliable diagnostic tests for determining levels of free heme in biological samples. The severity of hemolysis and heme toxicity is currently indirectly estimated by Hp and Hx levels [11,17]. Thus, a practical and specific test is urgently needed to determine labile heme in biological fluids and tissues.…”
Section: Discussionmentioning
confidence: 99%
“…Screening for hemolysis uses a variety of tests, which often must be interpreted in unison and with knowledge of the patient's medical history. 11 Haptoglobin is a protein that acts as a scavenger of free hemoglobin, thereby protecting the body from its toxic effects. 12 Low haptoglobin levels are sensitive for hemolysis, but are not specific, because severe liver disease, transfusions, and regular exercise can lead to low levels.…”
Section: Hemolysismentioning
confidence: 99%