Torque teno virus: a ubiquitous virus

Oliveira, Karen Brajão de

doi:10.1016/j.bjhh.2015.07.009

Cited by 15 publications

(10 citation statements)

References 14 publications

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“…This observation corroborates data from well-characterized mammalian CRESS-DNA viruses (PCV1; Allan & Ellis, 2000 ; TTV; Okamoto, 2009 ), which often manifest asymptomatically in healthy host tissue. We speculate that LM29173, like other CRESS-DNA viruses, may evade host clearance, attenuate innate immune responses, or elicit host tolerance through post-transcriptional or translational gene regulation, ultimately establishing persistent and asymptompatic infections ( Brajão de Oliveira, 2015 ; Okamoto, 2009 ). This hypothesis may explain the universal prevalence and diversity of these viruses in aquatic ecosystems, as observed by metaviromic sequencing.…”

Section: Resultsmentioning

confidence: 99%

Gene expression of benthic amphipods (genus:Diporeia) in relation to a circular ssDNA virus across two Laurentian Great Lakes

Bistolas

Rudstam²,

Hewson

2017

PeerJ

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Circular rep-encoding ssDNA (CRESS-DNA) viruses are common constituents of invertebrate viral consortia. Despite their ubiquity and sequence diversity, the effects of CRESS-DNA viruses on invertebrate biology and ecology remain largely unknown. This study assessed the relationship between the transcriptional profile of benthic amphipods of genus Diporeia and the presence of the CRESS-DNA virus, LM29173, in the Laurentian Great Lakes to provide potential insight into the influence of these viruses on invertebrate gene expression. Twelve transcriptomes derived from Diporeia were compared, representing organisms from two amphipod haplotype clades (Great Lakes Michigan and Superior, defined by COI barcode sequencing) with varying viral loads (up to 3 × 106 genome copies organism−1). Read recruitment to de novo assembled transcripts revealed 2,208 significantly over or underexpressed contigs in transcriptomes with above average LM29173 load. Of these contigs, 31.5% were assigned a putative function. The greatest proportion of annotated, differentially expressed transcripts were associated with functions including: (1) replication, recombination, and repair, (2) cell structure/biogenesis, and (3) post-translational modification, protein turnover, and chaperones. Contigs putatively associated with innate immunity displayed no consistent pattern of expression, though several transcripts were significantly overexpressed in amphipods with high viral load. Quantitation (RT-qPCR) of target transcripts, non-muscular myosin heavy chain, β-actin, and ubiquitin-conjugating enzyme E2, corroborated transcriptome analysis and indicated that Lake Michigan and Lake Superior amphipods with high LM29173 load exhibit lake-specific trends in gene expression. While this investigation provides the first comparative survey of the transcriptional profile of invertebrates of variable CRESS-DNA viral load, additional inquiry is required to define the scope of host-specific responses to potential infection.

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Section: Resultsmentioning

confidence: 99%

Gene expression of benthic amphipods (genus:Diporeia) in relation to a circular ssDNA virus across two Laurentian Great Lakes

Bistolas

Rudstam²,

Hewson

2017

PeerJ

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“…Viruses belonging to the Anelloviridae family, also ssDNA/circular, are widely distributed worldwide. Nevertheless, neither the type of interaction with their hosts nor their direct association with the etiology of specific diseases is entirely understood [22]. Previously, studies suggested the association with pathological conditions, such as hepatitis, cancer, and respiratory diseases as well as hematological and autoimmune disorders [23].…”

Section: Discussionmentioning

confidence: 99%

Viral diversity in oral cavity from Sapajus nigritus by metagenomic analyses

et al. 2020

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Sapajus nigritus are non-human primates which are widespread in South America. They are omnivores and live in troops of up to 40 individuals. The oral cavity is one of the main entry routes for microorganisms, including viruses. Our study proposed the identification of viral sequences from oral swabs collected in a group of capuchin monkeys (n = 5) living in a public park in a fragment of Mata Atlantica in South Brazil. Samples were submitted to nucleic acid extraction and enrichment, which was followed by the construction of libraries. After high-throughput sequencing and contig assembly, we used a pipeline to identify 11 viral families, which are Herpesviridae, Parvoviridae, Papillomaviridae, Polyomaviridae, Caulimoviridae, Iridoviridae, Astroviridae, Poxviridae, and Baculoviridae, in addition to two complete viral genomes of Anelloviridae and Genomoviridae. Some of these viruses were closely related to known viruses, while other fragments are more distantly related, with 50% of identity or less to the currently available virus sequences in databases. In addition to host-related viruses, insect and small vertebrate-related viruses were also found, as well as plant-related viruses, bringing insights about their diet. In conclusion, this viral metagenomic analysis reveals, for the first time, the profile of viruses in the oral cavity of wild, free ranging capuchin monkeys.

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“…TTV infection is one of the most ubiquitous viruses in humans and this infection has been suggested to be related to various diseases, although there is no direct proof of such association [9] . HCV infection is one of the commonest infections encountered with TTV, with several studies reporting such association.…”

Section: Discussionmentioning

confidence: 99%

Phylogenetic Analysis of Torque Teno Virus in Thalassemic Children in Egypt

et al. 2017

Intervirology

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Objective: Torque teno virus (TTV) is a ubiquitous virus that is commonly associated with blood transfusion. The main aims of this study were to evaluate the incidence of TTV in polytransfused children with thalassemia and to determine for the first time the prevalent TTV genotypes in Egypt. Methods: TTV was detected in 2 groups by nested PCR: the first group comprised 200 children with thalassemia, and the second included age- and sex-matched healthy children with no history of blood transfusion. Results: TTV was detected in 60 and 57%, respectively, of the children with thalassemia and the healthy children. Among the TTV-positive children with thalassemia, 71.6% were HCV positive. No hepatitis B surface antigen was detected in the thalassemic children. Significant elevations of alanine transaminase and aspartate transaminase were found in TTV-positive patients with thalassemia compared to TTV-negative patients. Phylogenetic analysis of sequenced TTV isolates showed close relationships to genotypes 1 and 2. Conclusion: TTV is highly prevalent among children with thalassemia in Egypt, with a relatively high infection rate also detected among healthy children.

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Torque teno virus: a ubiquitous virus

Cited by 15 publications

References 14 publications

Gene expression of benthic amphipods (genus:Diporeia) in relation to a circular ssDNA virus across two Laurentian Great Lakes

Gene expression of benthic amphipods (genus:Diporeia) in relation to a circular ssDNA virus across two Laurentian Great Lakes

Viral diversity in oral cavity from Sapajus nigritus by metagenomic analyses

Phylogenetic Analysis of Torque Teno Virus in Thalassemic Children in Egypt

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