Prevalence of Torque teno virus in healthy donors of Paraná State, southern Brazil

Abstract

ObjectiveTo determine the prevalence of the Torque teno virus in healthy donors in the northern and northwestern regions of the state of Paraná, southern Brazil.MethodsThe Torque teno virus was detected by a nested polymerase chain reaction using a set of oligoprimers for the N22 region.ResultsThe prevalence of the virus was 69% in 551 healthy blood donors in southern Brazil. There was no statistically significant difference between the presence of the virus and the variables gender, ethnicity and marital status. There was significant difference in the prevalence of the virus regarding the age of the donors (p-value = 0.024) with a higher incidence (74.7%) in 18- to 24-year-old donors.ConclusionA high prevalence of Torque teno virus was observed in the population studied. Further studies are needed to elucidate the routes of contamination and the clinical implications of the virus in the healthy population.

The Molecular Epidemiology and Phylogeny of Torque Teno Virus (TTV) in Jordan

“…Similarly, the difference in prevalence between individuals who had a history of receiving blood transfusions and those who did not (90.5% and 95.7%, respectively) is also small in magnitude and in the opposite direction to that expected if blood transfusions were responsible for introducing TTV to the subjects. Similar to our findings here, a number of studies failed to find a significant relationship between TTV prevalence and subject characteristics in other countries, including Egypt [41], Russia [42], Brazil [40], Iran [23] and Qatar [10]. Conversely, a number of studies reported a significant association between TTV prevalence and subject attributes in other countries, including: gender [sic] in the UAE [43]; blood transfusion history in Iran [23]; age in the UK [44], China [19], Brazil [40] and Qatar [10]; and obesity in Romanian women [45].…”

“…Within the relatively narrow confines of Jordan (the farthest samples are less than 450 km apart), no significant differences in prevalence among regions were detected. This is to be contrasted with a number of studies of much larger countries which reported geographical variation in TTV prevalence (3%-72% in India [36,37]; 2%-34% in Iran [9,23] and 6%-85% in Brazil [38][39][40]). The fact that these wide ranges were reported by different studies per country, leaves open the possibility that the observed within-country difference in prevalence might be at least partly due to variation in methodology (sampling scheme, sets of primers used, year of study, etc.)…”

Current Views of Torque Teno Virus (TTV) in Liver Diseases

“… доноры крови [23,[67][68][69];  больные гемофилией [70][71][72];  пациенты с многократными гемотрансфузиями [73][74][75][76];…”

“…Распространенности инфекции способствует заражение крови и ее продуктов вирусом TT [23,67,68,73,78,88,89]. Так, инфицированность продуктов крови и факторов свертывания VIII и IX, по данным P. Simmonds и соавт., составляет 44-56 % [88].…”

Torque teno virus: a ubiquitous virus

“…In this article, the authors demonstrated the prevalence of the TTV in healthy donors in the northern and northwestern regions of the state of Paraná, southern Brazil, by nested PCR using a set of primers for the N22 region. 9 …”