A case of chronic myeloid leukemia with the m-bcr (p190) molecular rearrangement identified during treatment

A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow

“…To avoid the misdiagnosis of CML as CMML, it was proposed that the absence of relative monocytosis (a PB monocyte frequency of >8%; it was 8.5% in the present case) should be a criterion for the diagnosis of CML when the total number of leukocytes is higher than 20×10 9 /L ( 25 ). Ph-positive CML rarely expresses the p190 BCR-ABL transcript, which is often accompanied by prominent monocytosis and a hematological phenotype that is intermediate between those of CML and CMML ( 27 - 29 ). In our case, the conventional p210 BCR-ABL transcript, but not the p190 BCR-ABL transcript, was detected during an analysis based on the reverse transcription polymerase chain reaction.…”

Coexistence of P190 BCR/ABL transcript and CALR 52-bp deletion in chronic myeloid leukemia blast crisis: a case report

“…This rare fusion transcript, also known as minor breakpoint cluster region (m-bcr), codes for a smaller (190kDa) oncoprotein with a unique clinical presentation between CML and chronic myelomonocytic leukemia (CMML). 4 …”

A case of e1a2 (minor, P190) BCR-ABL1-positive chronic myeloid leukemia in Korea

“…TO THE EDITOR: Minor BCR-ABL1 -positive chronic myeloid leukemia (CML) is a very rare subtype of CML, with only 1–2% of patients with CML exhibiting this fusion gene as a sole rearrangement [ 1 ]. Amongst the several reported cases in literature, and to the best of our knowledge, only one case has been reported in Korea so far [ 2 ].…”