Frequency of p190 and p210 BCR-ABL rearrangements and survival in Brazilian adult patients with acute lymphoblastic leukemia

Abstract

ObjectiveThis study investigated the occurrence of the p190 and p210 breakpoint cluster region-Abelson (BCR-ABL) rearrangements in adults with acute lymphoblastic leukemia and possible associations with clinical and laboratory characteristics and survival.MethodsForty-one over 18-year-old patients with acute lymphoblastic leukemia of both genders followed-up between January 2008 and May 2012 were included in this study. Clinical and laboratory data were obtained from the medical charts of the patients. Reverse transcription polymerase chain reaction (RT-PCR) using specific primers was employed to identify molecular rearrangements.ResultsAt diagnosis, the median age was 33 years, and there was a predominance of males (61%). The most common immunophenotype was B lineage (76%). BCR-ABL rearrangements was detected in 14 (34%) patients with the following distribution: p190 (28%), p210 (50%) and double positive (22%). Overall survival of patients with a mean/median of 331/246 days of follow up was 39%, respectively, negative BCR-ABL (44%) and positive BCR-ABL (28%).ConclusionThese results confirm the high frequency of BCR-ABL rearrangements and the low survival rate of adult Brazilian patients with acute lymphoblastic leukemia.

Philadelphia kromozomu olan akut lenfoblastik lösemi hastalarında p210 kırılma noktası P190 kırılma noktasına göre daha az minimal kalıntı hastalığı ile ilişkilidir

“…In the study conducted by Bartram et al (3) Ph chromosome was found in 25% of adult ALL patients and up to 50% in older ALL patients. In the study conducted by Azevedo et al (32) Ph chromosome was found in 34% of Brazilian adult patients with ALL. Gleier et al (24) showed that 37% of 478 adult ALL patients had BCR-ABL fusion gene.…”

Edad y recuento leucocitario como factores pronósticos en leucemia linfoblástica aguda: cohorte hgmla07

“…Sin embargo, dos de los cuatro factores que realmente impactan sobre la supervivencia libre de la enfermedad, la edad y la cifra de leucocitos al momento del diagnóstico, son variables clínicas de fácil detección 14,18 . La media de edad obtenida en la población analizada es similar a las reportadas en Latinoamérica, y ligeramente menor a la de estudios anglosajones [19][20][21][22] . El género a pesar de influir significativamente en la edad al momento de diagnóstico, menor para el género masculino, no fue un factor de impacto para la supervivencia libre de la enfermedad, ensombreciendo el pronóstico tanto para hombres como mujeres con edad igual o mayor a los 20 años.…”

Leucemia linfoblástica aguda do adulto: resultados da otimização da avaliação genética e dos protocolos terapêuticos

“…Poucas iniciativas de pesquisa em LLA do adulto foram conduzidas na América Latina nos últimos anos. Levantamentos retrospectivos unicêntricos tem evidenciado que a sobrevida da população adulta é inferior à de países desenvolvidos (21)(22)(23)(24)(37)(38)(39).…”