Risk factors associated with the occurrence of adverse events in plateletpheresis donation

Abstract

ObjectiveTo recognize the profile of platelet donors and the profile of the plateletpheresis session as well as to investigate the main adverse events of platelet donation using plateletpheresis and associated risk factors.MethodsThis retrospective, cross-sectional and analytical study was performed with a quantitative approach by analyzing 316 donation files from February 2010 to December 2011. The IBM SPSS Statistics program was used for data processing and analysis. The chi-square test was used to verify whether there was an association between factors related to the procedure and the donor, and the adverse events that occurred.ResultsThe mean age of platelet donors was 40 years old (standard deviation = 8.9), with the prevalent age group being between 40 and 49 years old; the prevalent blood type was O positive (53.8%), the mean duration of the procedure was 73 min and the mean amount of anticoagulant used was 360 mL. The association between procedure duration and the volume of anticoagulant was inverse and statistically significant; the longer the procedure and the greater the volume of anticoagulant used, the less adverse reactions occurred.ConclusionThe low incidence of adverse events indicates that the procedure is well tolerated by donors. Obtaining data regarding the incidence of adverse events is a way of promoting a dynamic review of medical and nursing teams to improve the safety and comfort of the donor.

Adverse Events During Apheresis Procedures: Audit at a Tertiary Hospital

“…These are usually the result of faulty phlebotomy techniques leading to extravasation of blood. Present study reported an occurrence of 1.2 % of vascular injuries among all the plateletpheresis procedures which is similar to that reported by Barbosa et al [1] and Philip et al [1,6]. Most of the vascular injuries were committed by the relatively inexperienced newly joined staff nurses or the technical staffs in the apheresis lab.…”

“…This well-known phenomenon is the result of the chelation of ionised calcium by the citrate present in ACD [8]. We found 2.7 % of the reported citrate reactions that is higher than that reported by Philip et al [6] but lower than that reported by Barbosa et al [1] which may be attributed to administration of oral calcium tablets to the donors at the beginning of the procedures, difference in the donor characteristics, duration of the procedures and equipments used. McLeod et al [4] reported 0.39 % of overall citrate reactions among donors undergoing apheresis procedures in his multi-institutional study.…”

“…Over decades, increased demand of platelet transfusions for patients with various medical and surgical diagnoses led to accelerated usage of technologically advanced ''Apheresis'' for platelet concentrates which is conducted under the transfusion medicine specialist's supervision in special dedicated areas [1]. In apheresis, whole blood is drawn from healthy donors, processed in specialized equipments viz.…”

The role of thrombocytapheresis in the contemporary management of hyperthrombocytosis in myeloproliferative neoplasms: A case-based review

“…Women are more affected by hypotension than men [71]. Other factors influencing the risk of hypotension include height of the individual, model of apheresis machine, and mode of plasma collection [72]. Allergic reactions previously seen with apheretic procedures have decreased considerably with the use of more biocompatible polymer systems.…”

A liquid calcium+vitamin D3 supplement is effective prophylaxis against hypocalcemic toxicity during apheresis platelet donation

“…Hypocalcemic toxicity is a common adverse effect of apheresis platelet donation . It is caused by the return to the donor of plasma carrying a citrate‐based anticoagulant, and may limit the blood flow rate and component yield during collection procedures .…”