Association between intraoperative ketamine and the incidence of emergence delirium in laparoscopic surgeries: an observational study

Pereira, Hélder; Antunes, M.; Teles, Daniel; Pereira, Luís Guimarães; Abelha, Fernando

doi:10.1016/j.bjane.2022.10.002

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…Ketamine may contribute to emotion and mood regulation via inhibiting some neuronal pathways [7]. Te assumption that the psychotomimetic efects of ketamine may lead to ED is still a debate, and despite the controversial literature, this link was not established [18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Impact of Ketamine on Quality of Recovery after Laparoscopic Surgery: A Single-Centre Single-Blinded Trial Using the QoR-15 Questionnaire

Pereira

Graça

Fonseca

et al. 2023

Anesthesiology Research and Practice

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Background. The quality of recovery is a cluster of patient-related outcomes that emphasise not only pain but different physical and emotional dimensions. Traditionally, ketamine is used to improve postoperative analgesia and avoid opioid consumption and opioid-related side effects. Objective. The present study sought to evaluate if intraoperative ketamine administration (as a part of multimodal analgesia) influences the quality of recovery after laparoscopic surgery. Design. A prospective two-armed, single-blinded trial. Settings. Tertiary single-centre trial between July 2021 and January 2022. Patients. From the 146 patients initially admitted to the study, 127 patients were enrolled, 60 in the ketamine group (group K) and 67 in the control group (group NK). Intervention. Both groups received a rigid intraoperative anaesthesia protocol; furthermore, in group K, 0.5 mg/kg of the ideal body weight of ketamine was administered. Main Outcome Measures. The primary outcome was to evaluate the effect of ketamine administration on the postoperative quality of recovery using the Portuguese version of the Quality of Recovery-15 (QoR-15) Questionnaire 24 h after surgery. The total score and minimal clinically significant difference (MCID) of the QoR-15 were compared. Other variables were also assessed such as the presence of emergence delirium (ED), the Numeric Rating Scale (NRS) for pain, and the presence of postoperative nausea and vomiting (PONV). Results. A total of 127 patients were allocated to the study groups, 60 in group K and 67 in group NK. Regarding the primary outcome, no differences were found in individual categories (15 items) and in the total score of QoR-15 ( p = 0.214 ). Concerning improvement (MCID ≥ 8) or worsening (MCID ≤ 8) in quality of recovery, no difference was found between the groups (24 vs. 32 and 6 vs. 6; p = 0.776 ). Finally, no difference was found in secondary postoperative outcomes including ED ( p = 0.55 ), NRS ( p = 0.401 ), and PONV ( p = 0.55 ). Conclusion. In this study, the administration of ketamine in laparoscopic surgery had no impact on the quality of recovery 24 h after surgery. This trial is registered with NCT03724019.

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Section: Discussionmentioning

confidence: 99%

Impact of Ketamine on Quality of Recovery after Laparoscopic Surgery: A Single-Centre Single-Blinded Trial Using the QoR-15 Questionnaire

Pereira

Graça

Fonseca

et al. 2023

Anesthesiology Research and Practice

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“…Laparoscopic cholecystectomy is widely used for the treatment of gallbladder stones which is one of the most common digestive diseases worldwide 1–5. However, these patients commonly suffer from postoperative pain due to surgical manipulation, the increase in intra-abdominal pressure and peritonitis caused by bile 6–8. Especially, ~13% of patients who underwent laparoscopic cholecystectomy experienced severe pain in the first week after surgery, and 17% to 41% of them were hospitalized due to severe pain 6…”

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confidence: 99%

The Efficacy of Foot Massage for Pain Relief of Laparoscopic Cholecystectomy: A Meta-analysis Study

Cheng

Zhou

Wang

2023

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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Background: Foot massage may have some potential in improving pain relief in patients undergoing laparoscopic cholecystectomy, and this meta-analysis aims to explore the impact of foot massage on pain control after laparoscopic cholecystectomy.Materials and Methods: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched, and we included randomized controlled trials assessing the effect of foot massage on pain control after laparoscopic cholecystectomy.Results: Five randomized controlled trials were included in the meta-analysis. Overall, compared with control intervention for laparoscopic cholecystectomy, foot massage was associated with significantly lower pain scores at 60 minutes [mean difference (MD) = −1.19; 95% CI = −2.01 to −0.38; P = 0.004), pain scores at 90 minutes (MD = −1.41; 95% CI = −1.73 to −1.10; P < 0.00001), pain scores at 120 to 150 minutes (MD = −2.20; 95% CI = −2.49 to −1.90; P < 0.00001) and reduced need of additional analgesia (odd ratio = 0.04; 95% CI = 0.02-0.08; P < 0.00001), but demonstrated no obvious effect on pain scores at 10 to 30 minutes (MD = −0.25; 95% CI = −0.79 to 0.29; P = 0.37).Conclusions: Foot massage benefits to improve pain control after laparoscopic cholecystectomy.

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Association between intraoperative ketamine and the incidence of emergence delirium in laparoscopic surgeries: an observational study

Cited by 2 publications

References 24 publications

Impact of Ketamine on Quality of Recovery after Laparoscopic Surgery: A Single-Centre Single-Blinded Trial Using the QoR-15 Questionnaire

Impact of Ketamine on Quality of Recovery after Laparoscopic Surgery: A Single-Centre Single-Blinded Trial Using the QoR-15 Questionnaire

The Efficacy of Foot Massage for Pain Relief of Laparoscopic Cholecystectomy: A Meta-analysis Study

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