Evaluation of lignocaine, dexmedetomidine, lignocaine-dexmedetomidine infusion on pain and quality of recovery for robotic abdominal hysterectomy: a prospective randomized controlled trial

Shivaji, Pudi; Agrawal, Sanjay; Kumar, Ajay; Bahadur, Anupama

doi:10.1016/j.bjane.2021.10.005

Cited by 7 publications

(14 citation statements)

References 29 publications

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“…After reading the title and abstract, 2502 articles that did not meet the inclusion criteria were eliminated. After full text reading and screening of the remaining 43 articles, 13 articles [10][11][12][13][14][15][16][17][18][19][20][21][22] were nally included (including 1131 patients, 486 in the lidocaine group, and 489 in the control group) (Fig. 1).…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…14) 3.4 Postoperative analgesia 3.4.1 Postoperative VAS scores. Three RCTs [10,15,18] evaluated the pain at 12 and 24 hours after surgery, respectively. Metaanalysis results showed that, in the lidocaine intravenous infusion group, VAS scores at 12 hours (WMD: -0.31; 95% CI: 0.69 ~ 0.07; P = 0.11; I 2 = 64%; Egger's publication bias P = 0.985) and 24 hours (WMD: -0.18; 95% CI: 0.43 ~ 0.04; P = 0.02; I 2 = 34%; Egger's publication bias P = 0.204) after surgery had no signi cant difference(Fig.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…3.6 Bowel function recovery. Five RCTs [10,[15][16][17][18] reported time to recovery of postoperative bowel function (time to rst atus or defecation). Meta-analysis results showed that the postoperative bowel function recovery time in the lidocaine group was signi cantly shorter than that in the control group (WMD: -3.85; 95% CI: 5.94 ~ 1.75; P = 0.0003; I 2 = 93%) (Fig.…”

Section: 43mentioning

confidence: 99%

“…There have been many clinical randomized controlled studies on the effect of systemic intravenous lidocaine on postoperative analgesic and the quality of postoperative recovery, but the results are still controversial. Some studies [10][11][12][13][14][15][16][17][18][19] believe that lidocaine, as part of perioperative multimode analgesic, can signi cantly reduce postoperative pain and improve the quality of postoperative recovery. Some studies [20][21][22] believed that a perioperative systemic intravenous infusion of lidocaine could not relieve postoperative pain and promote postoperative recovery of patients.…”

Section: Introductionmentioning

confidence: 99%

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The effects of lidocaine intravenous infusion on postoperative pain and quality of recovery: What should we expect from a systematic review and Meta-analysis

Guo

Huang

et al. 2023

Preprint

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Background: Perioperative intravenous infusion of lidocaine has become part of multimode analgesia in opioid-free anesthesia, which can reduce postoperative pain and improve postoperative recovery quality. However, the results of this discussion are still in dispute. The purpose of this systematic review and meta-analysis was to determine the effect of intravenous lidocaine infusion on postoperative recovery quality and analgesic in adult patients undergoing general anesthesia. Methods: PubMed, EMBASE, Web of Science database, and Google Scholar were systematically searched for randomized controlled trials, regardless of language and publication platform. A total of 13 randomized controlled trials (1131 patients) were included. The primary outcome measures were the total Quality of Recovery (QoR-40) on the first postoperative day (POD1) and Visual Analogue Scale (VAS) and Numeric Rating Scale (NRS) at different postoperative time points. Secondary outcome measures were the incidence of postoperative nausea or vomiting, time to recovery of intestinal function, and length of hospital stay. Data extraction and bias risk assessment were conducted independently by two researchers. Results: Systemic intravenous infusion of lidocaine on the first postoperative day(POD1) significantly improved the quality of recovery(QoR-40)(WMD, weighted mean difference 4.98；95%CI, confidence interval 1.78 to 8.19；P value =0.002；heterogeneity, I2=63%), NRS pain scores were significantly decreased at rest and movement at 0.5 h postoperative（Rest status: WMD, -0.70; 95%CI:-1.05~-0.35; P=0.0001; I2=0%）（Movement status: WMD, -0.76；95%CI:-1.18~-0.34; P=0.0004; I2=9%）. There were no significant differences in VAS and NRS pain scores at other time points. Conclusions: Low-risk bias evidence suggests that intravenous lidocaine improves QoR-40 scores on the first day after general anesthesia and reduces postoperative pain during resuscitation. However, this conclusion needs to be further confirmed by a large number of high-quality randomized controlled trials.

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Section: Study Selection and Characteristicsmentioning

confidence: 99%

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Section: 43mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effects of lidocaine intravenous infusion on postoperative pain and quality of recovery: What should we expect from a systematic review and Meta-analysis

Guo

Huang

et al. 2023

Preprint

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“…The lidocaine/dexmedetomidine combination resulted in lower PO pain scores and fentanyl consumption, in addition to enhanced quality recovery. 29 …”

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confidence: 99%