Downregulation of CSF-derived miRNAs miR-142-3p and miR-17-5p may be associated with post-dural puncture headache in pregnant women upon spinal anesthesia

Yücel, Duygu

doi:10.1016/j.bjane.2021.08.016

Cited by 3 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PCSF is an important parameter in clinical management and diagnosis of several neurological diseases including hydrocephalus, IIH and demyelinating disorders. These diseases may present with overlapping symptoms such as headache and visual defects (24)(25)(26). Therefore, a quick and accurate assessment of PCSF is essential.…”

Section: Discussionmentioning

confidence: 99%

A novel approach to CSF pressure measurement via lumbar puncture that shortens the clinical measurement time with a high level of accuracy

Yücel

Ülgen

2023

Preprint

Self Cite

View full text Add to dashboard Cite

Intracranial pressure (ICP) is an important parameter in clinical management and diagnosis of several neurological diseases. ICP is indirectly measured via lumbar puncture (LP) using a spinal manometer in clinical practice. In routine measurements of cerebrospinal fluid pressure (PCSF) from lumbar region, prolonged measurement times and low accuracy are of great concern. This measurement system consists of a spinal needle used for LP and a spinal manometer to measure PCSF. In this study, the spinal needle-spinal manometer combination was modelled with a first-order differential equation and a time constant (τ ) was defined as the product of the resistance to flow of the needle with the bore area of the manometer divided by the dynamic viscosity of CSF, i.e. τ = RA/ρCSF. Each needle/manometer combination had a unique constant as a predictor of the equilibrium pressure. The fluid pressure in the manometer rose in an exponential manner which was tested in a simulated environment using 22G spinal needles namely Braun-Spinocan, Pajunk-Sprotte and M.Schilling. Curve fitting of the manometer readings were obtained with regression coefficients of R2 ≥ 0,99 to determine measurement time constants. The residual differences between predicted and true values were less than 1,18 cmH2O. For a given needle/manometer combination, time required to reach equilibrium pressure was identical for all pressure levels. PCSF measured at reduced times can easily be interpolated to their equilibrium level allowing clinicians to obtain PCSF values with high accuracy within seconds. This method can be used as an indirect estimation of ICP in routine clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

A novel approach to CSF pressure measurement via lumbar puncture that shortens the clinical measurement time with a high level of accuracy

Yücel

Ülgen

2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…P CSF is an important parameter in clinical management and diagnosis of several neurological diseases including hydrocephalus, IIH and demyelinating disorders. These diseases may present with overlapping symptoms such as headache and visual defects [ 25 – 27 ]. Therefore, a quick and accurate assessment of P CSF is essential.…”

Section: Discussionmentioning

confidence: 99%

A novel approach to CSF pressure measurement via lumbar puncture that shortens the measurement time with a high level of accuracy

Yücel

Ülgen

2023

BMC Neurosci

Self Cite

View full text Add to dashboard Cite

Intracranial pressure (ICP) is an important parameter in clinical management and diagnosis of several neurological diseases which is indirectly measured via lumbar puncture (LP). In routine measurements of cerebrospinal fluid pressure (PCSF) from lumbar region, a spinal needle and a spinal manometer are used. PCSF measurement via LP with the use of a spinal manometer may not yield correct PCSF results due to prolonged times required to obtain an accurate pressure value. Equilibrium pressure may be underestimated in circumstances where spinal manometry procedure is terminated prematurely, with the wrong assumption that equilibrium pressure is reached. Elevated PCSF levels can lead to visual loss and brain damage when go undiagnosed. In this study, the spinal needle-spinal manometer combination was modelled with a first-order differential equation and a time constant (τ) was defined as the product of the resistance to flow of the needle with the bore area of the manometer divided by the dynamic viscosity of CSF, i.e. τ= RA/ρCSF. Each needle/manometer combination had a unique constant as a predictor of the equilibrium pressure. The fluid pressure in the manometer rose in an exponential manner which was tested in a simulated environment using 22G spinal needles namely Braun-Spinocan, Pajunk-Sprotte and M.Schilling. Curve fitting of the manometer readings were obtained with regression coefficients of R2 ≥ 0.99 to determine measurement time constants. The residual differences between predicted and true values were less than 1.18 cmH2O. For a given needle/manometer combination, time required to reach equilibrium pressure was identical for all pressure levels. PCSF measured at reduced times can easily be interpolated to their equilibrium level allowing clinicians to obtain PCSF values with high accuracy within seconds. This method can be used as an indirect estimation of ICP in routine clinical practice.

show abstract

“…We read the article by Dr. Yucel with interest and appreciated the study showing the association of downregulation of CSF-derived miRNAs with post-dural puncture headache after cesarean delivery. 1 …”

mentioning

confidence: 99%

In reference to “Downregulation of CSF-derived miRNAs miR-142-3p and miR-17-5p may be associated with post-dural puncture headache in pregnant women upon spinal anaesthesia”

Önal

Duran

Önal

2022

Brazilian Journal of Anesthesiology (English Edition)

View full text Add to dashboard Cite

Downregulation of CSF-derived miRNAs miR-142-3p and miR-17-5p may be associated with post-dural puncture headache in pregnant women upon spinal anesthesia

Cited by 3 publications

References 36 publications

A novel approach to CSF pressure measurement via lumbar puncture that shortens the clinical measurement time with a high level of accuracy

A novel approach to CSF pressure measurement via lumbar puncture that shortens the clinical measurement time with a high level of accuracy

A novel approach to CSF pressure measurement via lumbar puncture that shortens the measurement time with a high level of accuracy

In reference to “Downregulation of CSF-derived miRNAs miR-142-3p and miR-17-5p may be associated with post-dural puncture headache in pregnant women upon spinal anaesthesia”

Contact Info

Product

Resources

About