Effect of adding clonidine to lidocaine on ocular hemodynamics during sub-Tenon’s anesthesia: randomized double-blind study

Cabral, Sigmar Aurea; Carraretto, Antônio Roberto; Sousa, Ângela Maria; Gomez, Renato Santiago

doi:10.1016/j.bjane.2021.08.004

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…20 The effect of anesthesia on ocular blood flow could be related to the direct mechanical compression or the pharmacological effects of local anesthetics. 5,21 In our study, the ischemic change in the retinal superficial and deep retinal capillary plexuses was more significant in glaucoma patients than in those without glaucoma. Peripapillary ischemia was significantly greater after peribulbar injection in the glaucoma group.…”

Section: Discussionmentioning

confidence: 43%

Quantitative OCT Angiography Assessment of the Effect of Peribulbar Anesthesia on Retinal Microvasculature in Primary Open-Angle Glaucoma Patients Undergoing Cataract Surgery

Awwad¹,

Masoud²,

Elhadad³

2022

OPTH

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To assess the effect of peribulbar anesthesia on retinal microvasculature in primary open-angle glaucoma (POAG) patients undergoing cataract surgery using OCT Angiography. Participants: Forty-nine patients undergoing cataract surgery were divided into two groups. Group I included patients with no history of glaucoma, while group II included patients previously diagnosed as POAG with controlled IOP. Each participant received 6 mL of peribulbar anesthetic injection of 4 mL lidocaine 2% containing 150 IU hyaluronidase and 2 mL bupivacaine 0.5%. They were scanned with the OCT-A 10 minutes before and 10 minutes after injection for foveal deep (DCP), superficial (SCP) capillary plexuses density and total vessel density, foveal avascular zone (FAZ) diameter, optic disc total vessel density, and radial peripapillary capillary (RPC) network density. In addition, IOP was checked before and 10 minutes after injection. Results: Median percent change in DCP post-injection was significantly greater in group II (−43%) than in group I (−2.5%) (P < 0.001). Also, DCP total density median percent change post-injection was significantly higher in group II (−21%) than in group I (−0.9%) (P < 0.001). Foveal SCP vessel density and total vessel density median percent change post-injection were −62.6% and −16.2%, respectively, in group II and were −2.6% and −1.1%, respectively, in group I, which are statistically significant (P < 0.001). The FAZ diameter median percentage change postinjection was higher in group II (40.6%) than in group I (2.5%) (P < 0.001). Optic disc total vessel density and radial peripapillary capillary (RPC) network density post-injection median percent change were significantly higher in group II (−13.6%) and (−13.1%) respectively than in group I (−1.1%) and (−1.25%) respectively (P < 0.001). Conclusion: Peribulbar anesthesia harbors a deleterious ischemic effect on the retinal vascular tree of glaucoma patients, which could harmfully affect the vision and the visual field in those vulnerable patients.

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Section: Discussionmentioning

confidence: 43%

Quantitative OCT Angiography Assessment of the Effect of Peribulbar Anesthesia on Retinal Microvasculature in Primary Open-Angle Glaucoma Patients Undergoing Cataract Surgery

Awwad¹,

Masoud²,

Elhadad³

2022

OPTH

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“…Consequently, drug accumulation‐associated toxicity and elevated plasma levels are more likely to occur when amide agents are used. [ 4 ] Examples of amide‐group local anesthetics used in ophthalmic surgery include lidocaine, [ 5 ] prilocaine (PRL), [ 6 ] and bupivacaine. [ 7 ] The choice of local anesthetic is based on the speed of action, duration of the inhibition, and desired potency.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory signal transduction pathways induced by prilocaine toxicity in cultured ARPE‐19 cells

Öztüzün

Çeker

Yılmaz

et al. 2023

J Biochem & Molecular Tox

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Prilocaine (PRL) is a common local anesthetic. Despite the successful use of regional anesthesia for intraocular surgery, there are associated side effects that may affect the retina in case of accidental intravitreal injection. This study examined the signal transduction pathways activated by PRL toxicity and determined the protective role of nitric oxide synthase‐2 (NOS2) inhibition in cultured human‐derived retinal pigment epithelial cells (ARPE‐19). Toxicity analysis was performed using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide assay to detect the toxic dose of PRL and protective effectiveness of asperglaucide (ASP), an NOS2 inhibitor. Nuclear factor kappa B p65 (NF‐κB p65), phosphorylated NF‐κB p65, phospho‐protein kinase B (AKT), NOS2, nitrotyrosine, and cleaved caspase‐3 protein levels were evaluated by immunofluorescence staining and/or western blot analysis. Interleukin‐6 (IL‐6) and nitrated protein levels were quantified using an immunoassay, whereas caspase‐3 activity and nitrite/nitrate levels were measured using a fluorometric method. A significant increase in NF‐κB p65, and phosphorylated NF‐κB p65 and AKT levels due to PRL toxicity was observed. Similarly, IL‐6, NOS2, nitrite/nitrate, and nitrotyrosine levels were significantly higher in PRL‐treated cells than in control cells. Application of ASP to PRL‐treated cells reduced NF‐κB p65, and phosphorylated NF‐κB p65 and AKT to basal levels. IL‐6, NOS2, nitrite/nitrate, and nitrotyrosine levels also considerably decreased following ASP treatment in cells experiencing PRL‐induced toxicity. Moreover, the caspase‐3‐dependent apoptotic pathway was not activated. Our results indicate that ASP could ameliorate PRL‐induced activation of NF‐κB p65 that led to inflammation in cultured ARPE‐19 cells.

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“…kg -1 of clonidine to the subtenion blockade for cataract surgeries reduced IOP and ocular pulse amplitude, without affecting eye perfusion pressure. 13 Both studies provide evidence on the correlation between ocular pressure and perfusion measurements, and volume of anesthetics in ophthalmological blocks and adding adjuvants, which is extremely important to avoid complications.…”

mentioning

confidence: 99%

“… 12 Cabral et al, in turn, assessed the effect of clonidine as adjuvant to anesthetic blockade on IOP and other eye perfusion parameters. 13 …”

mentioning

confidence: 99%

Comprehensive perioperative eye protection

Carmona

Quintão

2021

Brazilian Journal of Anesthesiology (English Edition)

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Effect of adding clonidine to lidocaine on ocular hemodynamics during sub-Tenon’s anesthesia: randomized double-blind study

Cited by 4 publications

References 29 publications

Quantitative OCT Angiography Assessment of the Effect of Peribulbar Anesthesia on Retinal Microvasculature in Primary Open-Angle Glaucoma Patients Undergoing Cataract Surgery

Quantitative OCT Angiography Assessment of the Effect of Peribulbar Anesthesia on Retinal Microvasculature in Primary Open-Angle Glaucoma Patients Undergoing Cataract Surgery

Inflammatory signal transduction pathways induced by prilocaine toxicity in cultured ARPE‐19 cells

Comprehensive perioperative eye protection

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