“…According to Oliveira Filho et al, there is a great variation in the doses used for both drugs, from 0.2 to 0.75 mg.kg −1 for midazolam, and from 1 to 6 mg.kg −1 for ketamine, as well as the use of different pharmaceutical formulations. 11 The oral midazolam solution has adequate bioavailability for administration by this route, but when the parenteral presentation is used orally, changes in the solution's pH may occur, causing medication bioavailability and absorption changes interfering in the effectiveness of midazolam. 13 …”