Comparison of minimal-flow sevoflurane versus desflurane anesthesia: randomized clinical trial

Taş, Berna Ayanoğlu; Karip, Ceren Şanlı; Abitağaoğlu, Süheyla; Arı, Dilek Erdoğan

doi:10.1016/j.bjane.2021.05.012

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…The findings revealed that the HR and mean blood pressure values did not carry out a considerable difference in the application of different FGF. Taş et al 30 evaluated the effects of minimal flow sevoflurane and minimal flow desflurane anesthesia on hemodynamic parameters, organ function and blood gas in patients undergoing posterior spinal instrumentation and found that hemodynamic parameters were alike among the 2 groups. It was concluded that minimal FGF did not cause hemodynamic disturbance and can be used safely.…”

Section: Discussionmentioning

confidence: 99%

The effect of low flow anesthesia with sevoflurane on oxidative status

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et al. 2022

SMJ

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Objectives: To assess the impact of low-flow, mid-flow, and high-flow sevoflurane anesthesia on the oxidative state by measuring thiol/disulfide levels in patients undergoing surgery. Methods:The study included 99 patients randomly assigned to 3 groups. In the low-flow anesthesia group, the fresh gas flow was diminished to 1 L.min -1 for anesthesia maintenance after 6 L.min -1 was administered for the first 10 minutes. In the mid-flow anesthesia group, fresh gas flow was applied as 2 L.min -1 . In the high-flow anesthesia group, the fresh gas flow was administered as 4 L.min -1 throughout the operation. Blood samples were obtained before induction, at the 60th minute after induction, and at 2 hours postoperatively. Native thiol, total thiol, disulfide analyzed and disulfide/ native thiol percentage, disulfide/total thiol percentage, and native thiol/total thiol percentage were calculated. Original ArticleResults: Disulfide values in mid-flow and low-flow anesthesia were significantly lower at the 60th minute after induction compared to the high-flow anesthesia group. In the group evaluations, intraoperative native thiol levels in the high-flow group were found to be substantialy lower than preoperative values. Conclusion:It was sighted that low-flow anesthesia with sevoflurane prohibited oxidative damage. It was concluded that low flow anesthesia can be utilized safely in this respect.

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Section: Discussionmentioning

confidence: 99%

The effect of low flow anesthesia with sevoflurane on oxidative status

Kaşıkara

Özcan

Bıçer

et al. 2022

SMJ

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“…In view of the reliability and cost-effectiveness of anesthesia, no significant differences were found between desflurane, sevoflurane, and isoflurane in basic performance on liver and kidney function, respiratory parameters, and blood gas levels. 19,20 The type, duration, and frequency of exposure to volatile anesthetics before myocardial ischemia have been shown to be potentially relevant in in vitro experiments. 21 The ability of anesthetic preconditioning from isoflurane to sevoflurane to desflurane to protect the myocardium has been found to be significantly enhanced.…”

Section: Desfluranementioning

confidence: 99%

Myocardial Protection by Desflurane: From Basic Mechanisms to Clinical Applications

Han

Jun

2023

Journal of Cardiovascular Pharmacology

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Coronary heart disease (CHD) is an affliction that is common and has an adverse effect on patients' quality of life and survival while also raising the risk of intraoperative anesthesia. Mitochondria are the organelles most closely associated with the pathogenesis, development and prognosis of CHD. Ion abnormalities, an acidic environment, the production of reactive oxygen species, and other changes during abnormal myocardial metabolism cause the opening of mitochondrial permeability transition pores, which disrupts electron transport, impairs mitochondrial function, and even causes cell death. Differences in reliability and cost-effectiveness between desflurane and other volatile anesthetics are minor, but desflurane has shown better myocardial protective benefits in the surgical management of patients with coronary artery disease. The results of myocardial protection by desflurane are briefly summarized in this review, and biological functions of the mitochondrial permeability transition pore, mitochondrial electron transport chain, reactive oxygen species, atp-dependent potassium channels, G protein-coupled receptors, and protein kinase C are discussed in relation to the protective mechanism of desflurane. This article also discusses the effects of desflurane on patient hemodynamics, myocardial function, and postoperative parameters during coronary artery bypass grafting. Although there are limited and insufficient clinical investigations, they do highlight the possible advantages of desflurane and offer additional suggestions for patients.

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Comparison of minimal-flow sevoflurane versus desflurane anesthesia: randomized clinical trial

Cited by 2 publications

References 15 publications

The effect of low flow anesthesia with sevoflurane on oxidative status

The effect of low flow anesthesia with sevoflurane on oxidative status

Myocardial Protection by Desflurane: From Basic Mechanisms to Clinical Applications

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