“…Concurrently, Remifentanil, an ultra-short-acting opioid analgesic, targets mu-opioid receptors, mitigating pain perception. Propofol and Remifentanil, when used in combination, have demonstrated a synergistic impact in enhancing anesthesia effectiveness; Propofol reduces Remifentanil dosage requirements during anesthesia to achieve synergistic inhibition of reactions to procedures such as laryngoscopy, intubation, and surgical incitements [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. In addition, Remifentanil synergistically decreases the dosage requirement of Propofol to achieve anesthesia, which is associated with the return to consciousness.…”