The effect of alpha-2A adrenergic receptor (ADRA2A) genetic polymorphisms on the depth of sedation of dexmedetomidine: a genetic observational pilot study

Choi, Yoon-Dong; Park, Kyu Hee; Park, Ju Yeon; Min, Won Kee; Lee, Yoon Sook

doi:10.1016/j.bjane.2021.04.005

Brazilian Journal of Anesthesiology (English Edition)

2022

DOI: 10.1016/j.bjane.2021.04.005

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The effect of alpha-2A adrenergic receptor (ADRA2A) genetic polymorphisms on the depth of sedation of dexmedetomidine: a genetic observational pilot study

Yoon-Dong Choi

Kyu Hee Park

Ju Yeon Park

et al.

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2023

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Genetic polymorphisms are associated with individual susceptibility to dexmedetomidine

Ding,

Liu,

Wang

et al. 2023

Front. Genet.

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Introduction: Dexmedetomidine (DXM) is widely used as an adjuvant to anesthesia or a sedative medicine, and differences in individual sensitivity to the drug exist. This study aimed to investigate the effect of genetic polymorphisms on these differences.Methods: A total of 112 patients undergoing hand surgery were recruited. DXM 0.5 μg/kg was administered within 10 min and then continuously injected (0.4 μg/kg/h). Narcotrend index, effective dose and onset time of sedation, MAP, and HR were measured. Forty-five single nucleotide polymorphisms (SNPs) were selected for genotype.Results: We observed individual differences in the sedation and hemodynamics induced by DXM. ABCG2 rs2231142, CYP2D6 rs16947, WBP2NL rs5758550, KATP rs141294036, KCNMB1 rs11739136, KCNMA1 rs16934182, ABCC9 rs11046209, ADRA2A rs1800544, and ADRB2 rs1042713 were shown to cause statistically significant (p < 0.05) influence on the individual variation of DXM on sedation and hemodynamics. Moreover, the multiple linear regression analysis indicated sex, BMI, and ADRA2A rs1800544 are statistically related to the effective dose of DXM sedation.Discussion: The evidence suggests that the nine SNPs involved in transport proteins, metabolic enzymes, and target proteins of DXM could explain the individual variability in the sedative and hemodynamic effects of DXM. Therefore, with SNP genotyping, these results could guide personalized medication and promote clinical and surgical management.

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Genetic polymorphisms are associated with individual susceptibility to dexmedetomidine

Ding,

Liu,

Wang

et al. 2023

Front. Genet.

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show abstract

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The effect of alpha-2A adrenergic receptor (ADRA2A) genetic polymorphisms on the depth of sedation of dexmedetomidine: a genetic observational pilot study

Cited by 1 publication

References 22 publications

Genetic polymorphisms are associated with individual susceptibility to dexmedetomidine

Genetic polymorphisms are associated with individual susceptibility to dexmedetomidine

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