Evaluation of dexmedetomidine anesthesia-related temperature changes: preliminary retrospective observational study

Cruz, Felipe Aparecido Ferreira da; Falcão, Luiz Fernando dos Reis; Amaral, José Luiz Gomes do; Silva, Helga Cristina Almeida da

doi:10.1016/j.bjane.2021.02.062

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…In humans, dexmedetomidine has been reported to cause hyperthermia; however, the mechanism is not fully known. 36 Perhaps the initial vasoconstriction that generally results from alpha-2 administration resulted in diminished heat loss earlier in the anesthetic monitoring period in the current study, resulting in higher temperatures in the AKD group over the AKM group. 37 Depth of anesthesia was evaluated in this study based on the reflexes monitored during the anesthetic period.…”

Section: Discussionmentioning

confidence: 70%

Anesthetic effects of alfaxalone-ketamine-midazolam and alfaxalone-ketamine-dexmedetomidine administered intramuscularly in black-tailed prairie dogs (Cynomys ludovicianus)

Hiebert

Eshar

Sarvi

et al. 2022

ajvr

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OBJECTIVE To evaluate and compare the anesthetic effects of alfaxalone-ketamine-midazolam (AKM) and alfaxalone-ketamine-dexmedetomidine (AKD) in black-tailed prairie dogs (Cynomys ludovicianus). ANIMALS 9 male black-tailed prairie dogs. PROCEDURES Prairie dogs were anesthetized with AKM (6 mg/kg alfaxalone, 30 mg/kg ketamine, and 1.5 mg/kg midazolam) and AKD (6 mg/kg alfaxalone, 30 mg/kg ketamine, and 0.15 mg/kg dexmedetomidine) in a prospective, complete cross-over study. Atipamezole (1.5 mg/kg) after AKD or flumazenil (0.1mg/kg) after AKM was administered 45 minutes after induction of anesthesia. Onset of general anesthesia, physiologic parameters, depth of anesthesia, and time to recovery after reversal administration were evaluated for each treatment. RESULTS Both AKM and AKD produced a deep plane of anesthesia in black-tailed prairie dogs that varied in duration. The median induction times for AKM and AKD were 82 and 60 seconds, respectively. The median recovery times for AKM and AKD were 27 and 21 minutes, respectively. There were no significant differences between protocols for induction (P = .37) and recovery (P = .51) times. All measured reflexes were absent in all animals at 5 minutes postinduction, with hindlimb reflexes returning prior to forelimb reflexes. Heart rate was lower but respiratory rate was higher in the AKD treatment. Body temperature decreased significantly for both protocols (P < .001) and was significantly lower with AKM than AKD (P < .001). CLINICAL RELEVANCE Both AKM and AKD produced a deep plane of anesthesia in black-tailed prairie dogs. For both protocols, heat support and oxygen support are indicated.

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Section: Discussionmentioning

confidence: 70%

Anesthetic effects of alfaxalone-ketamine-midazolam and alfaxalone-ketamine-dexmedetomidine administered intramuscularly in black-tailed prairie dogs (Cynomys ludovicianus)

Hiebert

Eshar

Sarvi

et al. 2022

ajvr

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“…The accelerated decline in BT is due to the drop in basal metabolism, which is primarily responsible for thermoregulation, and to exposure to the colder environment (Nascimento et al, 2021). The agonistic action of dexmedetomidine on the central α-2 receptor reduces vasoconstriction/ shivering thresholds and physiological responses for increasing BT (Cruz et al, 2022). Butorphanol has a weak effect on BT (Miller & Fowler, 2012;Thomas & Lerche, 2017), but drug interactions of this opioid cannot be ruled out.…”

Section: Btmentioning

confidence: 99%

Association of S(+) ketamine, dexmedetomidine and butorphanol for chemical restraint in scarlet macaws (Ara macao)

Caldas,

Gering,

Santos

et al. 2023

Braz. J. Vet. Res. Anim. Sci.

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The present study aimed at assessing the effects of combining 20 mg/kg S(+) ketamine with 25 μg/kg dexmedetomidine and 0.4 mg/kg butorphanol on the physiological parameters and anesthetic recovery time and score of eight captive scarlet macaw (Ara macao) specimens. These specimens were captured at the Marabá Zoobotanic Foundation (Fundação Zoobotânica de Marabá), Pará, using butterfly and mist nets, and subsequently subjected to the proposed protocol. The following physiological parameters were evaluated: heart rate (HR), respiratory rate (RR), saturation of peripheral oxygen (SpO2), body temperature (BT), and non-invasive blood pressure 5 min after drug administration (M0) and every 10 min thereafter (M1‒M5), with a total of 55 min of analysis of anesthetic effects. Glycemia was measured 5 min after drug administration and every 30 min thereafter. Anesthetic induction and recovery times were also determined. Among the parameters evaluated in this study, both HR and BT significantly decreased throughout the anesthetic period, with the lowest levels at 55 min after drug administration (M5). In contrast, RR did not significantly differ, and all animals remained stable, maintaining an RR close to a mean of 20 ± 8 cpm. Throughout the anesthetic period, SpO2 was 92 ± 5%, with no significant difference. The birds remained under spontaneous ventilation and without oxygen supplementation. Systolic, diastolic, and mean blood pressures remained stable, with no significant differences in any of these measurements. At M0 and M3, the glycemia decreased slightly, albeit with no significant difference justifying an adverse effect or even hypoglycemia. The anesthetic induction time, from M0 to decubitus, was 2.4 ± 0.7 min. The anesthetic recovery time, from M0 to effortless bipedal position and adequate phalangeal flexion, was 99.3 ± 32.4 min. The sedation was assessed as intense, and the anesthetic recovery was rated excellent in 62.5% and good in 37.5% of the animals.

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Dexmedetomidine/isoflurane/propofol

2022

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Evaluation of dexmedetomidine anesthesia-related temperature changes: preliminary retrospective observational study

Cited by 3 publications

References 28 publications

Anesthetic effects of alfaxalone-ketamine-midazolam and alfaxalone-ketamine-dexmedetomidine administered intramuscularly in black-tailed prairie dogs (Cynomys ludovicianus)

Anesthetic effects of alfaxalone-ketamine-midazolam and alfaxalone-ketamine-dexmedetomidine administered intramuscularly in black-tailed prairie dogs (Cynomys ludovicianus)

Association of S(+) ketamine, dexmedetomidine and butorphanol for chemical restraint in scarlet macaws (Ara macao)

Dexmedetomidine/isoflurane/propofol

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