The effect of 1-mg versus 3-mg granisetron on shivering and nausea in cesarean section: a randomized, controlled, triple-blind, clinical trial

Dehghanpisheh, Laleh; Azemati, Simin; Hamedi, Mahdi; Fattahisaravi, Zeinabsadat

doi:10.1016/j.bjane.2021.02.049

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…A similar study in 2021 also compared 3mg with 1mg granisetron in 244 patients undergoing cesarean section, and inferred that post spinal shivering, nausea and vomiting were significantly lowered with high dose granisetron. 19 Thus action of granisetron is dose dependent. Our study uses a higher dose of the drug i.e.…”

Section: Discussionmentioning

confidence: 99%

Granisetron versus Ondansetron: Comparison of 5HT3 antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients

Wahid

Ali²,

Yasin³

et al. 2022

Pak J Med Sci

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Objectives: To evaluate and compare the Ondansetron and Granisetron in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients Methods: The comparative analytical study was conducted at Combined Military Hospital, Rawalpindi, from September to October, 2021. One hundred and twenty pregnant women undergoing cesarean section, were enrolled in the study via non probability convenience sampling, and divided into three groups containing 40 participants each based on the type of antiemetic premedication they received, if any: Group N were those not requiring antiemetic premedication, Group O consisted of those given ondansetron 4mg, and Group G had those receiving 3mg granisetron, 15 minutes prior to administration of spinal anaesthesia. Systolic blood pressures and heart rates were recorded before and at multiple intervals after spinal anaesthesia was administered. Episodes of hypotension and bradycardia were recorded. Requirement of phenylephrine and atropine as rescue drugs was recorded for each participant. Results: There was a statistically significant difference in incidence of hypotension among the three groups (p value <0.001), with both drugs being superior to the control group (p value <0.001 for both), and 3mg granisetron being superior to 4mg ondansetron (p value <0.001). As for incidence of bradycardia, ondansetron and granisetron were superior to control group (p value 0.03 and <0.001 respectively), but there was no significant difference between the two drug groups (p value 0.094). Conclusion: High dose granisetron (3mg) is superior to low dose ondansetron (4mg) in preventing hemodynamic fluctuations induced by spinal anaesthesia. doi: https://doi.org/10.12669/pjms.38.7.5585 How to cite this:Wahid M, Ali S, Yasin B, Farhat K, Noor M, Syed FT. Granisetron versus Ondansetron: Comparison of 5HT3 antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients. Pak J Med Sci. 2022;38(7):---------. doi: https://doi.org/10.12669/pjms.38.7.5585 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Granisetron versus Ondansetron: Comparison of 5HT3 antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients

Wahid

Ali²,

Yasin³

et al. 2022

Pak J Med Sci

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“…3,10 Non-pharmacological preventive measures include fluid warmers, operating room temperature monitoring, heating blankets and surgical sterile cloths, but these are are less effective in increasing core body temperature. 1,3,13,14,16 Several pharmacological interventions such as clonidine, tramadol, neostigmine, dexmedetomidine, magnesium sulfate, ketamine and opioids have been reported to be effective but with varied success rate and potential side effects, including hemodynamic changes such as hypotension, hypertension, hallucinations, sedation, respiratory depression and nausea and vomiting. 1,4,5,[10][11][12]16 Recently, a 5-HT3 receptor antagonists has been suggested to prevent postoperative shivering with comparable efficacy with minimal side effects.…”

Section: Introductionmentioning

confidence: 99%

“…1,3,13,14,16 Several pharmacological interventions such as clonidine, tramadol, neostigmine, dexmedetomidine, magnesium sulfate, ketamine and opioids have been reported to be effective but with varied success rate and potential side effects, including hemodynamic changes such as hypotension, hypertension, hallucinations, sedation, respiratory depression and nausea and vomiting. 1,4,5,[10][11][12]16 Recently, a 5-HT3 receptor antagonists has been suggested to prevent postoperative shivering with comparable efficacy with minimal side effects. Granisetron is a potent 5-HT3 receptor antagonist with fewer side effects than other antiemetics.…”

Section: Introductionmentioning

confidence: 99%

Comparison of granisetron 10 µg/kg vs 40 µg/kg intravenous for prophylaxis of shivering after spinal anesthesia for lower abdominal surgery

Wahid,

Pradian,

Prihartono

2023

Anaesth. pain intensive care

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Background & Objective: Postanesthetic shivering is one of the many complications during recovery that is marked by vasoconstriction and involuntary movements in several muscle groups and psychologically is an incredibly uncomfortable experience for the patient. The 5-HT3 receptor antagonist granisetron can potentially be used to manage postanesthetic shivering through the thermoregulation neurotransmission system. This study aims to compare the effects of administering 10 µg/kg or 40 µg/kg of granisetron intravenously on the grade of shivering post spinal anesthesia in lower abdominal surgeries. Methodology: This study was a single-blind experimental study conducted on 30 patients who underwent spinal anesthesia for lower abdominal surgeries in Dr. Hasan Sadikin Hospital Bandung. There were no statistical differences of age, weight, height, BMI, core temperature before anesthesia, block height, room temperature, total bleeding, input volume, duration of surgery, and use of ephedrine between the two intervention groups. Results: Administration of 40 µg/kg intravenous granisetron could maintain the body temperature above 36.56 °C , better than the 10 µg/kg intravenous granisetron with the lowest temperature at 35.31 °C. Regarding the grade of shivering, administration of 40 µg/kg granisetron IV was able to improve postanesthetic shivering up to grade 2 in 3 (20%) patients, while 10 µg/kg intravenous granisetron improved grade of shivering to grade 3 in 5 (33%) patients, these results were statistically significant (P < 0.05). Conclusion: In conclusion, administration of granisetron 40 µg/kg IV reduces the incidence and severity of shivering post spinal anesthesia, and maintains a better core temperature compared to granisetron 10 µg/kg IV.Keywords: 5-Ht3 Receptor Antagonist; Granisetron; Postanesthetic Shivering; Prophylaxis Citation: Wahid WR, Pradian E, Prihartono MA. Comparison of granisetron 10 µg/kg vs 40 µg/kg intravenous for prophylaxis of shivering after spinal anesthesia for lower abdominal surgery. Anaesth. pain intensive care 2023;27(4):553−557; DOI: 10.35975/apic.v27i4.2265 Received: October 20, 2021; Reviewed: March 19, 2023; Accepted: June 22, 2023

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Which 5-HT3 antagonist prevents nausea and vomiting in cesarean section more effectively: a network meta-analysis

QIU,

WANG,

CHU

2024

Minerva Anestesiol

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The effect of 1-mg versus 3-mg granisetron on shivering and nausea in cesarean section: a randomized, controlled, triple-blind, clinical trial

Cited by 3 publications

References 16 publications

Granisetron versus Ondansetron: Comparison of 5HT3 antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients

Granisetron versus Ondansetron: Comparison of 5HT3 antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients

Comparison of granisetron 10 µg/kg vs 40 µg/kg intravenous for prophylaxis of shivering after spinal anesthesia for lower abdominal surgery

Which 5-HT3 antagonist prevents nausea and vomiting in cesarean section more effectively: a network meta-analysis

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