Sixty-two patients with plantar fasciitis were randomized to a placebo controlled trial testing the efficacy of a topical solution of plant terpenes containing camphor, menthol, eugenol, eucalyptol, and vanillin. Skin permeation of the mixture was enhanced with 15% dimethylsulfoxide (DMSO), 1% limonene, and rosemary oil. Using the validated foot function index 78.1% of patients reported an 85% or greater decrease in their total pain score by day 10 with twice daily application, while placebo treatment was without effect.
ClinicalTrials.gov Identifier: NCT05467631