Is Bordetella pertussis co-infecting SARS-CoV-2 patients?

Renzi, Samuele; Clementi, Massimo; Racca, Sara; Mucci, María; Beccaria, Paolo; Borghi, Giovanni; Landoni, Giovanni; Zangrillo, Alberto

doi:10.1016/j.bjane.2020.09.008

Cited by 3 publications

(3 citation statements)

References 4 publications

(3 reference statements)

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“…as the most common coinfecting bacteria in COVID-19 patients. Contrary to our study, multiple studies in different countries (Italy, Korea, and India) reported no cases of Bordetella coinfection among COVID-19 patients [ 54 , 56 , 59 ]. These findings need to be interpreted cautiously until further investigations are carried out (ongoing project by our team).…”

Section: Discussioncontrasting

confidence: 99%

Prevalence of SARS-COV-2 and other respiratory pathogens among a Jordanian subpopulation during Delta-to-Omicron transition: Winter 2021/2022

et al. 2023

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Acute respiratory tract infections (ARTIs) during the winter months are associated with higher morbidity and mortality compared to other seasons of the year, with children below five, elderly, and immunocompromised patients being the most susceptible. Influenza A and B viruses, rhinovirus, coronaviruses, respiratory syncytial virus, adenovirus, and parainfluenza viruses, are the most frequently identified causes of viral ARTIs. In addition, the emergence of SARS-CoV-2 in 2019 provided an additional viral cause of ARTIs. The aim of this study was to provide an overview of the epidemiological status of upper respiratory infections, their main causative agents, and reported clinical presentation in the winter months of 2021, during two important surges of COVID-19 in Jordan. Nasopharyngeal samples were collected from 339 symptomatic patients during the period from December 2021 to March 2022, followed by nucleic acid isolation using a Viral RNA/DNA extraction Kit. The causative virus species associated with the patient’s respiratory symptoms was determined utilizing a multiplex real-time PCR targeting 21 viruses, 11 bacteria, and a single fungus. SARS-CoV-2 was identified in 39.2% of the patients (n = 133/339). A total of 15 different pathogens were also identified as co-infections among these 133 patients (n = 67/133). SARS-CoV-2-Bacterial coinfections (37.6%, n = 50/133) were the most frequent, with Bordetella species being the most common, followed by Staphylococcus aureus, and H.influenzae type B. Viral coinfection rate was 27.8% (n = 37/133), with Influenza B virus and Human bocavirus being the most common. In Conclusion, Both SARS-CoV-2, influenza B virus, and Bordetella accounted for the majority of infections in patients with URTI during the winter months of 2021–2022. Interestingly, more than 50% of the patients with symptoms of URTIs were confirmed to have a coinfection with two or more respiratory pathogens, with SARS-CoV-2 and Bordetella coinfection being most predominant.

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Section: Discussioncontrasting

confidence: 99%

Prevalence of SARS-COV-2 and other respiratory pathogens among a Jordanian subpopulation during Delta-to-Omicron transition: Winter 2021/2022

et al. 2023

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“…However, Sambul et al [ 48 ] reported a very significant inverse correlation between pertussis antibody titers and risk of COVID-19 ( p = 0.0001) in a case-controlled study, but these titers did not distinguish between asymptomatic and severe cases ( p = 0.49) or mild and severe cases ( p = 0.11) of COVID-19 so that while pertussis vaccination may protect against SARS-CoV-2 infection, it does not seem to moderate disease severity. Notably, the role of pertussis itself as a super-infection in COVID-19 is also contradictory: pertussis superinfections of SARS-CoV-2 were significantly increased over control cases of other viral pneumonias in one Chinese study [ 79 ], but a Brazilian study found no B. pertussis among their COVID-19 patients [ 80 ]. Thus, the role of pertussis in COVID-19 and the efficacy of pertussis vaccination are in need of further investigation.…”

Section: Introductionmentioning

confidence: 99%

Pneumococcal and Influenza Vaccination Rates and Pneumococcal Invasive Disease Rates Set Geographical and Ethnic Population Susceptibility to Serious COVID-19 Cases and Deaths

Root‐Bernstein

2021

Vaccines

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This study examines the relationship of pneumococcal vaccination rates, influenza, measles-mumps-rubella (MMR) diphtheria-tetanus-pertussis vaccinations (DTP), polio, Haemophilus influenzae type B (Hib), and Bacillus Calmette–Guerin (tuberculosis) vaccination rates to COVID-19 case and death rates for 51 nations that have high rates of COVID-19 testing and for which nearly complete childhood, at-risk adult and elderly pneumococcal vaccination data were available. The study is unique in a large number of nations examined, the range of vaccine controls, in testing effects of combinations of vaccinations, and in examining the relationship of COVID-19 and vaccination rates to invasive pneumococcal disease (IPD). Analysis of Italian regions and the states of the United States were also performed. Significant positive correlations were found between IPD (but not lower respiratory infections) and COVID-19 rates, while significant negative correlations were found between pneumococcal vaccination and COVID-19 rates. Influenza and MMR vaccination rates were negatively correlated with lower respiratory infection (LRI) rates and may synergize with pneumococcal vaccination rates to protect against COVID-19. Pneumococcal and influenza vaccination rates were independent of other vaccination rates. These results suggest that endemic rates of bacterial pneumonias, for which pneumococci are a sentinel, may set regional and national susceptibility to severe COVID-19 disease and death.

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“…Более того, коклюш часто ассоциируются с респираторными вируса ми, включая сезонный коронавирус. Это приводит к тому, что случаи коклюша хуже диагностируются в период пандемии COVID-19, что заставляет сохра нять настороженность в этом отношении [8].…”

Section: Introductionunclassified

The clinical case of a combined new coronavirus infection and whooping cough in an unvaccinated child

Konstantinova¹,

Бабаченко

Харит

et al. 2023

jour

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Whooping cough remains a life-threatening infection, especially for unvaccinated young children. The article describes a case of severe and non-smooth course of whooping cough in an unvaccinated girl of 4 months of life from the family hearth of whooping cough and COVID-19. There were cases of COVID-19 and whooping cough in adults in the family, occurring under the mask of a mild respiratory infection, not verified before they were detected in a child and did not require hospitalization. The combined course of two infectious diseases COVID-19 and whooping cough in a 4-monthold unvaccinated girl contributed to the prolongation of the duration of whooping cough, prolonged release of SARS-COV-2 RNA, the late appearance of hematological changes typical of whooping cough, the development of respiratory delays and re-hospitalization of a patient with prolonged respiratory support. In the context of the COVID-19 pandemic, the coverage of routine vaccination has significantly decreased, as a result of which children of the first years of life have become more vulnerable to vaccine-controlled infections, which causes the risk of combined infections.

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Is Bordetella pertussis co-infecting SARS-CoV-2 patients?

Cited by 3 publications

References 4 publications

Prevalence of SARS-COV-2 and other respiratory pathogens among a Jordanian subpopulation during Delta-to-Omicron transition: Winter 2021/2022

Prevalence of SARS-COV-2 and other respiratory pathogens among a Jordanian subpopulation during Delta-to-Omicron transition: Winter 2021/2022

Pneumococcal and Influenza Vaccination Rates and Pneumococcal Invasive Disease Rates Set Geographical and Ethnic Population Susceptibility to Serious COVID-19 Cases and Deaths

The clinical case of a combined new coronavirus infection and whooping cough in an unvaccinated child

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