The effect of anesthetic preconditioning with sevoflurane on intracellular signal-transduction pathways and apoptosis, in a lung autotransplant experimental model

Garutti, Ignacio; González-Moraga, Francisco J.; Sánchez-Pedrosa, G.; Casanova, Javier; Martin-Piñeiro, Beatriz; Rancán, Lisa; Simón, Carlos; Vara, Elena

doi:10.1016/j.bjane.2018.07.003

Cited by 4 publications

(3 citation statements)

References 46 publications

(51 reference statements)

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“…Se ha evaluado la posible influencia de anestésicos sistémicos (sevoflurano) y locales (lidocaína) sobre el glicocálix, llegándose a la conclusión que disminuyen el daño ocasionado por el fenómeno IR. La administración de anestésicos podría ser potencialmente beneficiosa en el futuro [49,50].…”

Section: Mecanismos Fisiopatológicos Del Fenómeno Isquemia-reperfusiónunclassified

Revisión Bibliográfica: Glicocálix Endotelial como Blanco de Agresión del Fenómeno Isquemia Reperfusión

Villagómez¹,

Páez²,

González³

et al. 2019

Rev Med HJCA

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Bibliographic Review: Endothelial Glycocalyx as Target of Aggression of the Ischemia-Reperfusion InjuryThe endothelial glycocalyx is a structure rich in glycosaminoglycans, proteoglycans and glycoproteins that cover vascular endothelium; in addition of being a protective structure, the direct contact with blood turns it the target of aggression of multiple physiopathological mechanisms. The ischemia-reperfusion injury commonly presents in several critical care entities, including: ischemic stroke, acute coronary syndrome, sepsis and shock, major trauma, surgery and transplantation. Complications are multiple and dependent of the site of presentation; the common denominator is microvascular dysfunction that could potentially trigger multiple organ dysfunction syndrome. The aim of this bibliographic review was to update the knowledge regarding endothelial glycocalyx damage and ischemia-reperfusion injury.

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Section: Mecanismos Fisiopatológicos Del Fenómeno Isquemia-reperfusiónunclassified

Revisión Bibliográfica: Glicocálix Endotelial como Blanco de Agresión del Fenómeno Isquemia Reperfusión

Villagómez¹,

Páez²,

González³

et al. 2019

Rev Med HJCA

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“…In the study of the diaphragmatic index, Zhang et al considered that the blood lactate level and diaphragmatic motor function were two relatively independent indexes, and their independent prediction ability did not interfere with each other, and few researchers at home and abroad discussed the predictive value of the combination of the above two indexes in evaluating the outcome [ 6 ]. Garutti et al explored the predictive value of diaphragm motion parameters combined with the blood lactate level before and after SBT in evaluating the outcome in order to find a method that can accurately predict the outcome of patients receiving long-term mechanical ventilation and provide reference for clinical guidance in selecting the evaluation time [ 7 ]. Bertani et al proposed that the use of propofol or inhaled anesthetics during operation did not increase the risk of delirium within 3 days after cardiac surgery.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Evaluation of the Diaphragm in Clinical Anesthesia

Zhao

2022

Journal of Healthcare Engineering

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When the human body is anesthetized, the human nerve tissue will be greatly affected, which also affects the breathing of the human body. The respiration during anesthesia is a lack of initiative, and the energy efficiency of the diaphragm in the lungs is very important to the safety of anesthesia. In this paper, the application of the ultrasound evaluation of the diaphragm in clinical anesthesia was studied. In this paper, 24 patients who underwent lung examination under medical anesthesia at our hospital were evaluated by the ultrasound vertical mixed echo method. Through patient voluntary selection and consent, 16 patients were examined with B-mode ultrasound and the other 8 patients with M-mode ultrasound to compare the effects of different ultrasounds on diaphragm image quality. In addition, this paper also analyzes the differences between different ultrasounds and the strengths and weaknesses of diaphragmatic ultrasound evaluation in clinical anesthesia. The suggestions of using different ultrasounds in ultrasonic evaluation are given. The study showed that 16 cases of B-mode ultrasound evaluation of the diaphragm obtained ultrasound images which showed a large field of vision, acoustic frequency between 7 and 18 MHz, and thickness difference between 0.35 and 0.52 cm. In 8 patients with the diaphragm evaluated by M-mode ultrasound, the local features of M-mode ultrasound images were clearer than those of B-mode ultrasound images, but the visual field area was smaller, the acoustic frequency was between 10 and 15 MHz, and the thickness difference was between 0.12 and 0.18 cm. Based on the above data, this paper suggests that, in the ultrasonic evaluation of the diaphragm, B-mode ultrasound should be used to check the patients first, and then M-mode ultrasound should be used to check the parts with poor quality so that the accurate diaphragm quality of patients can be obtained in the vast majority of patients.

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“…5 The induction and regulation of apoptosis is complex, and this process involves a series of apoptosis-related factors and signal transduction pathways. 6,7 Therefore, it is important to reveal the mechanisms of neuronal apoptosis and reduce the apoptosis of neurons after cerebral I/R. Acute brain damage in the brain is caused by central necrosis, while secondary or late death is mainly caused by neuronal apoptosis in the ischemic penumbra.…”

Section: Introductionmentioning

confidence: 99%

<p>K-3-Rh Protects Against Cerebral Ischemia/Reperfusion Injury by Anti-Apoptotic Effect Through PI3K-Akt Signaling Pathway in Rat</p>

Sun¹,

Wang²,

Hu³

et al. 2020

NDT

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Background/Aims: Ischemic stroke is the main cause of nerve damage and brain dysfunction, accompanied by strong brain cell apoptosis. This study aimed to investigate the effect of kaempferol-3-O-rhamnoside (K-3-rh) on cerebral ischemia-reperfusion (I/R) injury. Methods and Materials: A rat model of cerebral I/R injury was established. The effects of K-3-rh on cerebral infarction size, brain water content and neurological deficits in rats were evaluated. Apoptosis of ischemic brain cells after mouse I/R was observed by TUNEL staining and flow cytometry. Western blot and qRT-PCR were used to detect the effect of K-3-rh on the expression of apoptosis-related proteins. Results: K-3-rh can improve the neurological deficit score, reduce the infarct volume and brain water content, and inhibit cell apoptosis. In addition, K-3-rh significantly downregulated the expression of Bax and p53 and upregulated the expression of Bcl-2, and the phosphorylation level of Akt. Blockade of PI3K activity by the PI3K inhibitor wortmannin not only reversed the effects of K-3-rh on infarct volume and brain water content but also reversed the expression level of p-Akt. Conclusion: K-3-rh had obvious neuroprotective effects on brain I/R injury and neuronal apoptosis, and its mechanism may be related to activation of PI3K/Akt signaling pathway.

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The effect of anesthetic preconditioning with sevoflurane on intracellular signal-transduction pathways and apoptosis, in a lung autotransplant experimental model

Cited by 4 publications

References 46 publications

Revisión Bibliográfica: Glicocálix Endotelial como Blanco de Agresión del Fenómeno Isquemia Reperfusión

Revisión Bibliográfica: Glicocálix Endotelial como Blanco de Agresión del Fenómeno Isquemia Reperfusión

Ultrasound Evaluation of the Diaphragm in Clinical Anesthesia

<p>K-3-Rh Protects Against Cerebral Ischemia/Reperfusion Injury by Anti-Apoptotic Effect Through PI3K-Akt Signaling Pathway in Rat</p>

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