Remifentanil–ketamine vs. propofol–ketamine for sedation in pediatric patients undergoing colonoscopy: A randomized clinical trial

Propofol use in newborns and children: is it safe? A systematic review

“…Table 3 shows the summary of articles involving the use of propofol in children. 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 …”

“…Mean pre- and post-procedure lactate values were 1.0 (0.3) and 0.7 (0.2) (p < 0.001). Karacaer et al (2018) 47 70 children (2–16 years) Randomized clinical trial in colonoscopy patients Comparison between ketamine + remifentanil (2 mg/kg and 0.25 mcg/kg respectively) and propofol + ketamine (1 mg/kg and 2 mg/kg) - Better intraoperative sedation and less need for rescue analgesia in the K + P group II Kang P et al (2018) 48 218 patients younger than 3 years (109 patients in the propofol group and 109 in the control group) Retrospective study - To assess the safety and efficacy of propofol for anesthesia maintenance using controlled infusion compared to inhalation anesthesia by evaluating clinical data of patients under 3 years of age. - Difference in the proportion of patients who had decreased SBP (p < 0.001) and HR (p = 0.03) under propofol use, but there was no difference in DBP (p = 0.238) or MBP (p = 0.175) during surgery.…”