Does dexmedetomidine prevent colistin nephrotoxicity?

Talih, Gamze; Esmaoğlu, Aliye; Bayram, Adnan; Yazıcı, Cevat; Denız, Kemal; Talih, Tutkun

doi:10.1016/j.bjane.2018.01.021

Cited by 5 publications

(2 citation statements)

References 19 publications

(25 reference statements)

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“…twice a day 20 min before the injection of colistin for seven days 10 mg/kg of I.P. CMS BUN, SCr, KIM-1, TAS, TOS, caspase-3 Decreased BUN, Cr, and TOS [ 71 ] Gelofusin Mice Cumulative I.P. doses of 450, 900, 1,800, and 3,600 mg/kg: 75, 150, 300, and 600 mg/kg every 2 h (6 doses) S.Q.…”

Section: Methodsmentioning

confidence: 99%

“…The altered parameters were improved using 10 and 20 mcg/kg IP dexmedetomidine 20 min before the administration of 10 mg/kg IP colistin twice a day for 7 days. Moreover, the apoptotic activity was evaluated via caspase-3 immunostaining, which indicated that the caspase-3 staining rate was lower in the dexmedetomidine group compared to the colistin group, but the difference was not statistically significant [ 71 ].…”

Section: Methodsmentioning

confidence: 99%

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Pharmacological agents for the prevention of colistin-induced nephrotoxicity

2022

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Background Colistin is a polymyxin antibiotic which has been used for treatment of Gram-negative infections, but it was withdrawn due to its nephrotoxicity. However, colistin has gained its popularity in recent years due to the reemergence of multidrug resistant Gram-negative infections and drug-induced toxicity is considered as the main obstacle for using this valuable antibiotic. Results In total, 30 articles, including 29 animal studies and one clinical trial were included in this study. These compounds, including aged black garlic extract, albumin fragments, alpha lipoic acid, astaxanthin, baicalein, chrysin, cilastatin, colchicine, curcumin, cytochrome c, dexmedetomidine, gelofusine, grape seed proanthocyanidin extract, hesperidin, luteolin, lycopene, melatonin, methionine, N-acetylcysteine, silymarin, taurine, vitamin C, and vitamin E exhibited beneficial effects in most of the published works. Conclusions In this review, the authors have attempted to review the available literature on the use of several compounds for prevention or attenuation of colistin-induced nephrotoxicity. Most of the studied compounds were potent antioxidants, and it seems that using antioxidants concomitantly can have a protective effect during the colistin exposure.

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