Comparison of granisetron and lidocaine on reducing injection pain of etomidate: a controlled randomized study

Saliminia, Alireza; Azimaraghi, Omid; Javadi, Amir; Abdoulahpoor, Maryam; Movafegh, Ali

doi:10.1016/j.bjane.2017.04.001

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…In another interventional study conducted by Alipour et al in Iran, 20 there were 336 patients in the six groups receiving ondansetron (4 mg intravenous), paracetamol (2 mg/kg intravenous), granisetron (2 mg), lidocaine (40 mg), magnesium sulfate (2 mg), and placebo (5 mL normal saline) before surgery and showed that all drugs had a significant reduction in pain intensity versus placebo; however, granisetron and lidocaine had the most effective outcome. 21 But in our study, the addition of ondansetron did not affect the reduction of pain.…”

Section: Discussioncontrasting

confidence: 65%

Paracetamol versus Paracetamol Plus Ondansetron on Acute Postoperative Pain

et al. 2021

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This study was performed to determine the comparative efficacy of paracetamol alone versus paracetamol plus ondansetron on acute postoperative pain after abdominal surgeries in Azad University hospitals in 2017 and 2019. In this randomized clinical trial, 62 consecutive patients under abdominal surgeries, were randomly divided into two groups, group 1 patient who received paracetamol alone 1 gram and group 2 patient who received paracetamol 1 gram plus 4 mg ondansetron and the pain severities were determined and compared between groups at recovery and after 4 and 24 hours. The results of this study revealed that there were no statistically significant differences between two groups for the postoperative pain severity and analgesic use (p> 0.05). It may be concluded that addition of ondansetron to paracetamol would not result in further postoperative pain reduction and additive use of this drug is not recommended.

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Section: Discussioncontrasting

confidence: 65%

Paracetamol versus Paracetamol Plus Ondansetron on Acute Postoperative Pain

et al. 2021

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“…[ 19 - 21 ] There have been numerous studies on the prevalence of pain due to the injection of the above drugs, and all of them have confirmed the sensation of injection pain. [ 5 10 12 14 ] In another study in 2017, injection pain was reported in the case of sodium thiopental and etomidate, and the intensity of injection pain in the etomidate group was higher than sodium thiopental group. [ 22 ] The above studies did not compare pain intensity due to the injection of the above drugs, and such limitation was eliminated in the present study.…”

Section: Introductionmentioning

confidence: 99%

Comparing intensity of pain due to intravenous injection of sodium thiopental, propofol, diazepam, and etomidate during induction of general anesthesia

Mansourian

Abdi

Alizadeh

et al. 2022

J Family Med Prim Care

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A BSTRACT Aim: The aim of the present study was to compare the pain intensity due to intravenous injection of sodium thiopental, propofol, diazepam, and etomidate during the induction of general anesthesia. Methods: This was a non-controlled quasi-experimental double-blinded study performed on eligible patients referred to the operating room of Shahid Beheshti Hospital in Yasouj. A total of 200 patients were randomly selected by convenience sampling and based on a table of random numbers generated on a computer. They were then randomly divided into four intervention groups based on random blocks (sodium thiopental, propofol, etomidate, and diazepam). Finally, the collected data were analyzed using descriptive as well as analytical statistical tests such as Chi-square, analysis of covariance (ANCOVA), and Bonferroni post hoc test were analyzed in SPSS ver. 24. Results: The results of the present study showed that the diazepam group experienced the highest pain intensity (8.42) compared to other groups, which was statistically significant ( P = 0.001). Also, the sodium thiopental group experienced the highest pain (6.92) after the diazepam group, which was also statistically significant as compared to the other remaining two groups ( P = 0.001). Propofol and etomidate groups experienced the lowest pain intensity (3.30 and 3.26, respectively). Conclusion: The present study revealed that the use of diazepam and sodium thiopental as anesthetic drugs was generally associated with greater pain intensity during injection and less hemodynamic stability. The results of the present study indicated that propofol and etomidate are preferred over diazepam and sodium thiopental in abdominal and gastrointestinal surgeries, considering their less pain intensity and fewer hemodynamic changes.

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Comparison of granisetron and lidocaine on reducing injection pain of etomidate: a controlled randomized study

Cited by 2 publications

References 23 publications

Paracetamol versus Paracetamol Plus Ondansetron on Acute Postoperative Pain

Paracetamol versus Paracetamol Plus Ondansetron on Acute Postoperative Pain

Comparing intensity of pain due to intravenous injection of sodium thiopental, propofol, diazepam, and etomidate during induction of general anesthesia

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