Impact of postoperative cognitive decline in quality of life: a prospective study

Borges, Joana; Moreira, Joana; Moreira, Adriano; Santos, Alice; Abelha, Fernando

doi:10.1016/j.bjane.2016.07.012

Cited by 14 publications

(11 citation statements)

References 37 publications

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“…Post-operative cognitive dysfunction (POCD) is a common post-operative complication affecting the central nervous system in elderly patients. It leads to increased medical costs for patients, impairs their recovery after surgery, and can even increase mortality (1). Risk factors for POCD include pain and being of the female sex (2,3), and the incidence of POCD is higher in elderly patients undergoing cardiovascular and orthopedic surgical procedures (4).…”

Section: Introductionmentioning

confidence: 99%

Effects of different analgesia regimens on early post‑operative cognitive dysfunction in elderly patients undergoing radical resection of cervical carcinoma

2019

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This study was designed to compare the effects of epidural and intravenous analgesia on early post-operative cognitive dysfunction (POCD) in elderly patients undergoing radical resection of cervical cancer. For this purpose, 74 patients aged 60-78 years [body mass index (BMI), 18-25 kg/m 2 ; American Society of Anesthesiologists (ASA) classification score of I-III) undergoing radical resection of cervical cancer were divided into the epidural group (group E) and parenteral group (group P) groups (37 patients in each group). All patients underwent their surgical procedures under epidural anesthesia and intravenously-delivered general anesthesia. Patient-controlled analgesia (PCA) was supplied for 72 h after the surgery. Epidural analgesia was provided for the patients in group E and intravenous analgesia was provide for those in group P. General patient information was recorded and peripheral blood neutrophil counts, C-reactive protein (CRP) levels and interleukin (IL)-6 concentrations were measured immediately prior to the surgery (T 0), and at 24, 48 and 72 h after the procedure (T 1 , T 2 and T 3 , respectively). Visual analog scale (VAS) scores were also recorded at T 1 , T 2 and T 3 , and the mini-mental state evaluation (MMSE) scores at T 0 , T 1 , T 2 , and T 3 were calculated. Patients were diagnosed as having POCD according to their MMSE score differences between the peri-operative and post-operative values. The results revealed that the levels of CRP and IL-6 significantly increased in both groups after the surgery (T 1-3). However, the CRP and IL-6 levels in group E were significantly lower than those in group P at all time points examined (P<0.05). The VAS scores in group E at T 1 , T 2 and T 3 were significantly lower than those in group P (P<0.05). Finally, the incidence of POCD in group E was significantly lower than that in group P (P<0.05). On the whole, the post-operative epidural analgesia reduced the systemic inflammatory response, the perceived pain, and the incidence of POCD in patients undergoing radical resection of cervical cancer, when compared with the effects of intravenous analgesia.

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Section: Introductionmentioning

confidence: 99%

Effects of different analgesia regimens on early post‑operative cognitive dysfunction in elderly patients undergoing radical resection of cervical carcinoma

2019

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“…126 It is linked to prolonged hospital stays, death, loss in ADL, and worsened QOL. 118,127,128 There is equipoise of evidence about the long-term recovery after perioperative cognitive impairment. Prior studies have reported recovery with improvement in the overall health status 125,129e132 ; however, these may have biases of repeated testing-learning effects and the absence of nonsurgical controls.…”

Section: Atherosclerotic Risk Factors Dmentioning

confidence: 99%

Comprehensive Geriatric Assessment in the Management of Older Patients With Cardiovascular Disease

Singh

Spertus

Gharacholou

et al. 2020

Mayo Clinic Proceedings

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Cardiovascular disease (CVD) disproportionately affects older adults. It is expected that by 2030, one in five people in the United States will be older than 65 years. Individuals with CVD now live longer due, in part, to current prevention and treatment approaches. Addressing the needs of older individuals requires inclusion and assessment of frailty, multimorbidity, depression, quality of life, and cognition. Despite the conceptual relevance and prognostic importance of these factors, they are seldom formally evaluated in clinical practice. Further, although these constructs coexist with traditional cardiovascular risk factors, their exact prevalence and prognostic impact remain largely unknown. Development of the right decision tools, which include these variables, can facilitate patient-centered care for older adults. These gaps in knowledge hinder optimal care use and underscore the need to rigorously evaluate the optimal constructs for providing care to older adults. In this review, we describe available tools to examine the prognostic role of age-related factors in patients with CVD.

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“…Multiple studies reported its usefulness in reducing postoperative neurocognitive events after cardiac surgery [1][2][3][4][5] . Neurocognitive impairments are common after cardiac surgery and associated with impaired quality of life 6 and increased health care costs 7 . Preventing cerebral desaturation using NIRS monitoring in coronary artery bypass surgery (CABG) was also reported to reduce length of stay in intensive care unit (ICU LOS) and major organ dysfunction 3,8 .…”

Section: Introductionmentioning

confidence: 99%

Interventions Triggered During Routine Use of NIRS Cerebral Oxygenation Monitoring in Cardiac Surgical Patients

Bochmann

Meineri

Ender

et al. 2022

Journal of Cardiothoracic and Vascular Anesthesia

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Impact of postoperative cognitive decline in quality of life: a prospective study

Cited by 14 publications

References 37 publications

Effects of different analgesia regimens on early post‑operative cognitive dysfunction in elderly patients undergoing radical resection of cervical carcinoma

Effects of different analgesia regimens on early post‑operative cognitive dysfunction in elderly patients undergoing radical resection of cervical carcinoma

Comprehensive Geriatric Assessment in the Management of Older Patients With Cardiovascular Disease

Interventions Triggered During Routine Use of NIRS Cerebral Oxygenation Monitoring in Cardiac Surgical Patients

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