Effect of equipotent doses of bupivacaine and ropivacaine in high-fat diet fed neonatal rodent model

Abstract

Ropivacaine and bupivacaine induced spinal toxicity that was more pronounced in over-fed rat pups as against normal controls.

Paresthesia in dentistry: The ignored neurotoxicity of local anesthetics

“…Some researchers found that T-lymphoma cells could be promoted by lidocaine by activating caspase-3 and releasing cytochrome C, which was accompanied by T-lymphoma cells viability reduction and a loss of the mitochondrial membrane potential, while in cells deficient in caspase-9, cell apoptosis induced by lidocaine was strongly reduced and lidocaine induced cell apoptosis was demonstrated through intrinsic caspase pathway [ 71 ]. In vivo , over-weight neonatal rats were administered ropivacaine and bupivacaine using intrathecal injection and both ropivacaine and bupivacaine could induce cell apoptosis and activate caspase-3 [ 72 ]. Ropivacaine promoted apoptosis of hepatocellular carcinoma cells through activating caspase-3 activity [ 73 ].…”