The effects of intra-cerebroventricular administered rocuronium on the central nervous system of rats and determination of its epileptic seizure-inducing dose

Baykal, Mehmet; Gökmen, Ali Necati; Doğan, Alper; Erbayraktar, Serhat; Yılmaz, Osman; Öçmen, Elvan; Erdost, Hale Aksu; Arkan, Atalay

doi:10.1016/j.bjane.2015.02.010

Cited by 2 publications

(2 citation statements)

References 16 publications

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“… 9 In addition, intrathecal NMBA administration induces autonomic dysfunction, cholinergic block, and seizures in rats. 6 , 10 , 11 Together, this evidence suggests that in patients with an impaired BBB, rocuronium can reach the CNS and cause dilated nonreactive pupils.…”

Section: Discussionmentioning

confidence: 91%

Rocuronium-Induced Dilated Nonreactive Pupils in a Patient With Coronavirus Disease 2019: A Case Report

et al. 2021

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We report the clinical case of a patient with coronavirus disease 2019 (COVID-19) who had recently undergone neurosurgery and presented with dilated nonreactive pupils during continuous rocuronium infusion, which was reversible with the suspension of the drug. Both the neurosurgical procedure and possible disruption of the blood–brain barrier due to COVID-19 infection may have led to the action of rocuronium in the central nervous system (CNS). Thus, clinicians must remember that neuromuscular blocking agents (NMBAs) can cause dilated nonreactive pupils in patients with COVID-19.

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Section: Discussionmentioning

confidence: 91%

Rocuronium-Induced Dilated Nonreactive Pupils in a Patient With Coronavirus Disease 2019: A Case Report

et al. 2021

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“…They reported that sugammadex had a protective eff ect against ischemiareperfusion injury in brain. But a recent study showed that rocuronium has dose-related deleterious eff ects on the central nervous system and can produce dose-dependent excitatory eff ects and seizures [21] . Also it is known that rocuronium can permeate the CSF after intravenous injection [22] .…”

Section: Discussionmentioning

confidence: 99%

Ratlarda Sugammadex ve Rocuronium Kombinasyonunun Kraniyal Nörotoksisite Üzerine Etkisi: Deneysel Çalışma

Uludağ¹

2019

Kafkas Univ Vet Fak Derg

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Sugammadex is frequently used in clinical anesthetic practice. In order to determine whether sugammadex has neurotoxic effect, histopathological evaluation and antioxidant status of brain and cerebellum tissues were investigated. Thirty-two adult sprague dawley rats were divided into four groups. Purine Control Group (Group 1, n=8) had no action. The control group (Group 2, n=8) received 16 mg/ kg serum physiologic, the sugammadex group (Group 3, n=8) received 16 mg/kg sugammadex and the sugammadex+rocuronium group (Group 4, n=8) received 16 mg/kg sugammadex and 1 mg/kg rocuronium. After drug administration, brain and cerebellum tissues were evaluated histological and biochemically for and oxidative damage. The overall structure of the brain and cerebellum tissues were normal in all groups. Images of the layers and the neurons contained there in were normal. No pathological findings were found. There had no statistically significant difference between the groups in terms of glutathione enzyme activity levels (GSH-Px) and the malondialdehyde (MDA) levels in rat brain. GSH-Px and MDA levels had a slight increase in sugammadex and sugammadex+rocuronium group in cerebellum tissues. These increases were statistically significant. But this increase did not cause any histopathological damage to the cerebellum tissue. The study demonstrates that sugammadex is safe for reversal of rocuronium effects in rats. Sugammadex in the dose ranges used in the studies, did not produce adverse effects in rats brain and cerebellum tissues.

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The effects of intra-cerebroventricular administered rocuronium on the central nervous system of rats and determination of its epileptic seizure-inducing dose

Abstract: This study showed that rocuronium bromide has dose-related deleterious effects on the central nervous system and can produce dose-dependent excitatory effects and seizures.

Cited by 2 publications

References 16 publications

Rocuronium-Induced Dilated Nonreactive Pupils in a Patient With Coronavirus Disease 2019: A Case Report

Rocuronium-Induced Dilated Nonreactive Pupils in a Patient With Coronavirus Disease 2019: A Case Report

Ratlarda Sugammadex ve Rocuronium Kombinasyonunun Kraniyal Nörotoksisite Üzerine Etkisi: Deneysel Çalışma

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