Effect of intraoperative esmolol infusion on anesthetic, analgesic requirements and postoperative nausea-vomitting in a group of laparoscopic cholecystectomy patients

Dereli, Necla; Tutal, Zehra Baykal; Babayiğit, Münire; Kurtay, Aysun; Sahap, Mehmet; Horasanlı, Eyüp

doi:10.1016/j.bjane.2014.08.007

Cited by 7 publications

(7 citation statements)

References 43 publications

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“…In current study, postoperative nausea and vomiting were less in group E in which only three patients experienced PONV in comparison to seven patients in group T but statistically insignificant. In Dereli et al study, they found that PONV incidence was significantly lowest in groups that received esmolol [16].…”

Section: Discussionmentioning

confidence: 91%

“…Followed by a significant decrease of MAP in esmolol group and remained higher in control group till the end of surgery [11]. Dereli et al conducted a similar trial and reported that HR was significantly lower in esmolol groups compared to controls (p = 0.001); but, blood pressures were comparable in all groups (p = 0.594) [16]. Other studies as well reported lower HR and/or MAP compared with controls [17,18].…”

Section: Discussionmentioning

confidence: 99%

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Does esmolol infusion have an adjuvant effect on transversus abdominis plane block for pain control in laparoscopic cholecystectomy? A randomized controlled double-blind trial

Abdelfatah

Amin

2021

Egyptian Journal of Anaesthesia

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Background: Both intraoperative esmolol and transversus abdominis plane (TAP) block facilitate postoperative analgesia after laparoscopic cholecystectomy as part of multimodal analgesia. Both strategies can minimize the use of postoperative opioids. In current study, our goal was to assess if intra-operative esmolol infusion in association with TAP block can overcome the deficits of TAP block alone after laparoscopic cholecystectomy. Methods: This prospective, randomized and double-blinded clinical trial included 60 patients of either sex who scheduled for elective laparoscopic cholecystectomy; received either ultrasound-guided TAP block alone or in association with intravenous esmolol bolus (0.5 mg/kg) before induction followed by a maintenance infusion (0.05 mg/kg/min) till the end of operation. Intra-operative hemodynamic parameters were followed up. Postoperatively, in order to maintain visual analogue scale (VAS) scores ≤3, patients received IV morphine. The primary outcome was amount of opioid consumption during the first 24 hours postoperative. Pain scores, mean arterial pressure (MAP), heart rate (HR) and occurrence of nausea/vomiting were secondary outcomes. Results: The mean morphine consumption after surgery in patients receiving esmolol was (5.83) mg compared to (7.5) mg in TAP only group (p = 0.204). The mean pain scores at early postoperative hours were significantly lower in esmolol group (p < 0.05). MAP and HR were significantly lower in esmolol group intraoperative; however, no variance was detected later. Conclusion:In the first 24 hours following surgery, esmolol infusion increased the analgesic impact of TAP block in terms of opioid demand and pain severity.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Does esmolol infusion have an adjuvant effect on transversus abdominis plane block for pain control in laparoscopic cholecystectomy? A randomized controlled double-blind trial

Abdelfatah

Amin

2021

Egyptian Journal of Anaesthesia

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“…We believe that all those causes can reduce PONV rates in these patients. 18 According to our results, the measured VAS score in PACU immediately after surgery and the next four hours was significantly lower in group E than in group N. The incidence of PONV and hypoxia were also significant in group Ein postoperative 24 hours compared with group N. Similarly analgesic requirements in postoperative 24 hours was significantly lower in group E compared with group N. Based on these results, we consider the use of esmolol during laparoscopic bariatric surgery for morbid obese patients to be useful compared to non-use of esmolol.…”

Section: Discussionmentioning

confidence: 99%

Role of intraoperative beta blocker for morbid obese patients undergoing laparoscopic bariatric surgery

Mahrose

Elgharabawy

2020

Sri Lankan J Anaesthesiol

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Background: Postoperative pain, nausea, vomiting (PONV) and hypoxia are common in relation to laparoscopic bariatric surgery. Sympatholytic drugs might decrease the need for intravenous or inhalation anaesthetics and opioids and also decrease postoperative adverse events. Method: Sixty patients were included. Propofol, fentanyl and rocuronium were used for induction. Study groups were as follows; group E, esmolol infusion was added to sevoflurane and fentanyl, group N only sevoflurane and fentanyl was used during maintenance of anaesthesia. Patients were monitored during the intraoperative period and postoperatively for 24 h for analgesic requirements and PONV. Visual analog scale (VAS) scores for pain was also assessed. Results: Analgesic and anaesthetic requirements were significantly lower in group E than in group N (P-value <0.05). VAS scores were significantly lower in group E than in group N (Pvalue <0.05). PONV incidence was significantly lower in group E than in group N (Pvalue <0.05). Heart rates and blood pressures were significantly lower in group E compared to group N (P-value <0.05) Conclusion: Using esmolol during anaesthetic maintenance of laparoscopic bariatric surgery significantly decreases anaesthetic and analgesic requirements, postoperative pain, PONV and postoperative hypoxia.

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“…They concluded that in light of depth of anaesthesia monitor, esmolol has no effect on requirement of isoflurane, but it decreases the postoperative pain as well as postoperative requirement of morphine without increasing the risk of awareness. Necla Dereli et al 7 from their study, sixty patients have been included, propofol, remifentanil and vecuronium were used for induction.…”

Section: Discussionmentioning

confidence: 99%

Influence of Esmolol on Requirement of Inhalational Agent Using Entropy and Assessment of Its Effect on Immediate Postoperative Pain Score

Rajendra¹,

Bias²

2016

jebmh

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This study aims to know the influence of esmolol on requirement of inhalational agent using entropy and also to assess the effect on immediate postoperative pain score. MATERIALS AND METHODS This study was conducted in 60 healthy ASA I and II patients. INCLUSION CRITERIA Body mass index (BMI) which is less than 25, age between 25 to 60 years of either sex who underwent lower abdominal surgeries. EXCLUSION CRITERIA Patients with history of allergy to opioids or halogenated anaesthetics, or taking drugs known to influence anaesthetic requirement including beta blockers, opioids, pregnant women and those who had cardiovascular, pulmonary, renal, hepatic diseases were excluded. Patients were divided into two groups, Group A and Group B depending on the infusion being used, esmolol in Group A and saline in Group B. RESULTS Age, body weight, ASA physical Status, total duration of surgeries (min.) and total isoflurane used was compared in both the groups and was non-significant (P>0.05). Pain was assessed in all the patients when they reached the postoperative room after extubation. VAS0 being the pain score at the time when they reached the postoperative room and VAS5, 10, 15, 20, 25 and 30 being the pain scores at respective time intervals which revealed a statistically significant difference in the VAS score between the groups at 5 and 10 min. intervals. Dose of morphine used at 5, 10, 15, 20, 25 and 30 min. for pain relief was calculated for both the groups and compared. Similarly, there was a statistically significant difference in morphine consumption at 5, 10, 25 and 30 min. intervals (P<0.05). Total dose of morphine used in 30 min. was also significantly less in Group A as compared to Group B (P<0.05). CONCLUSION Esmolol has no effect on requirement of isoflurane, but it decreases the postoperative requirement of morphine and postoperative pain without increasing the risk of awareness as concluded from this study.

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Effect of intraoperative esmolol infusion on anesthetic, analgesic requirements and postoperative nausea-vomitting in a group of laparoscopic cholecystectomy patients

Cited by 7 publications

References 43 publications

Does esmolol infusion have an adjuvant effect on transversus abdominis plane block for pain control in laparoscopic cholecystectomy? A randomized controlled double-blind trial

Does esmolol infusion have an adjuvant effect on transversus abdominis plane block for pain control in laparoscopic cholecystectomy? A randomized controlled double-blind trial

Role of intraoperative beta blocker for morbid obese patients undergoing laparoscopic bariatric surgery

Influence of Esmolol on Requirement of Inhalational Agent Using Entropy and Assessment of Its Effect on Immediate Postoperative Pain Score

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