Effects of various anesthesia maintenance on serum levels of selenium, copper, zinc, iron and antioxidant capacity

Akın, Mehmet; Ayoğlu, Hilal; Okyay, Dilek; Ayoğlu, Ferruh Niyazi; Gür, Abdullah; Çan, Murat; Yurtlu, Serhan; Hancı, Volkan; Küçükosman, Gamze; Turan, İşıl Özkoçak

doi:10.1016/j.bjane.2014.04.001

Cited by 10 publications

(12 citation statements)

References 57 publications

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“…The results showed that propofol (25, 50, and 100 μ M) could inhibit lipid peroxidation injury in cells. The result was consistent with previous report about propofol decreasing the levels of MDA [ 14 , 15 ].…”

Section: Resultssupporting

confidence: 93%

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Propofol Suppressed Hypoxia/Reoxygenation-Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl-2, Bax, Caspase3, Kir6.1, and p-JNK

Zhang

Xia

et al. 2016

Oxidative Medicine and Cellular Longevity

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Recent studies have found that propofol may protect brain from cerebral ischemic-reperfusion injury. However, the underlying mechanism remains unclear. The effects of propofol were evaluated in HBVSMC after hypoxia/reoxygenation (H/R). Cell viability and levels of SOD, LDH, and MDA were measured. Apoptosis was detected by flow cytometry. The levels of Bax, Bcl-2, Caspase3, Sur2b, Kir6.1, JNK, p-JNK, mTOR, and p-mTOR proteins were measured by western blotting. H/R decreased cell viability and SOD activity and increased LDH leakage and MDA content in HBVSMC, all of which were significantly reversed by propofol. Propofol suppressed the levels of H/R-induced apoptosis. The expression of Bcl-2 and p-mTOR was significantly downregulated and the expression levels of Bax, Caspase3, Kir6.1, and p-JNK were upregulated following H/R injury. The ratio of p-JNK/JNK was increased; however, that of p-mTOR/mTOR decreased correspondingly. The effects on the expression of these proteins were reversed by propofol treatment. SP600125 enhanced and Everolimus attenuated the effect of propofol. These findings suggested that the protective effect of propofol against H/R injury in the HBVSMC was through the inhibition of apoptosis by inducing the expression of Bcl-2 and p-mTOR as well as inhibiting the expression levels of Bax, Caspase3, Kir6.1, and p-JNK.

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Section: Resultssupporting

confidence: 93%

“…Superoxide dismutase (SOD) can protect cells from damage by elimination of oxygen free radicals. SOD is one of the endogenous antioxidative enzymes that protect against ROS-induced damage [ 15 ]. In H/R model group, the activities of SOD were significantly decreased compared with control group.…”

Section: Resultsmentioning

confidence: 99%

Propofol Suppressed Hypoxia/Reoxygenation-Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl-2, Bax, Caspase3, Kir6.1, and p-JNK

Zhang

Xia

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…In a recent study in men, Akin et al [25] evaluated serum levels of MDA, GSH-Px, selenium, copper, zinc and iron after exposure to sevofl urane, propofol or desfl urane. Sevofl urane and propofol anaesthesia decreased MDA concentrations and increased GSH-Px activity signifi cantly.…”

Section: Discussionmentioning

confidence: 99%

Influence of sevoflurane or propofol anaesthesia on oxidative stress parameters in dogs with early-stage myxomatous mitral valve degeneration. A preliminary study

et al. 2018

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The aim of this study was to investigate the effects of total intravenous anaesthesia with propofol and anaesthesia induced with propofol and maintained with sevoflurane on oxidative stress parameters in dogs with early-stage myxomatous mitral valve degeneration (MMVD). Sixteen client-owned dogs with early stage MMVD that required periodontal treatment were included in the study. After induction with propofol, anaesthesia was maintained with propofol (group P) or sevoflurane (group PS). Blood samples for determination of vitamin E, superoxide dismutase, glutathione peroxidase and malondialdehyde were collected before premedication, 5 and 60 minutes and 6 hours after induction to anaesthesia. There were no significant differences between groups in any of the oxidative stress parameters at each sampling time. Compared to basal values, vitamin E concentration decreased significantly during anaesthesia in both groups and glutathione peroxidase activity increased 60 minutes after induction to anaesthesia in PS group. Anaesthesia with propofol or with propofol and sevoflurane did not have any significant impact on oxidative stress parameters in dogs with early stage MMVD. In terms of oxidative stress, both protocols may be equally safely used in dogs with early stage MMVD.

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“…It was shown that oxidative stress changes trace elements levels. 13 Trace element levels in critical patients were decreased by factors such as increased oxidative stress, use of anti-oxidant systems, haemodilution with fluid resuscitation, renal replacement therapies, losses in biological fluids and inadequate intake. 14 Systemic inflammation affected oxidative stress in sepsis and SIRS.…”

Section: Discussionmentioning

confidence: 99%

Trace elements and septic shock in elderly patients

et al. 2017

The Egyptian Journal of Geriatrics and Gerontology

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Background: Sepsis is defined as an inflammatory body response to infection, with severe sepsis and septic shock being its more severe forms. 1 Despite advances in the management of septic patients, sepsis is still the second leading cause of death among patients in non-coronary intensive care units (ICU). 2 The number of elderly admitted to ICU is increasing in recent years due to increase survival. 3 Routinely, the macronutrient contribution is thoroughly studied when a patient is admitted to ICU. However, it must be kept in mind that along with macronutrients, micronutrients are also significant, and these must be taken into account. Previous studies tackled trace elements in relation to surgery complications 4 , and total parenteral nutrition. 5 Concerning sepsis, some studies were conducted to evaluate if trace elements are related to inflammation 6 , critical illness 7 and if supplementation would affect the outcome. 8 We aimed to evaluate baseline trace elements as s predictor of septic shock in Egyptian elderly patients within intensive care setting. Methods Prospective observational single central cohort study included all patients ≥ 60 years old, admitted to geriatric ICU during a 6 months period. Patients admitted for brief postoperative monitoring were excluded. The subjects were further subdivided into two groups. First group includes patients who developed septic shock. The second group included patients who did not develop septic shock.

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Effects of various anesthesia maintenance on serum levels of selenium, copper, zinc, iron and antioxidant capacity

Cited by 10 publications

References 57 publications

Propofol Suppressed Hypoxia/Reoxygenation-Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl-2, Bax, Caspase3, Kir6.1, and p-JNK

Propofol Suppressed Hypoxia/Reoxygenation-Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl-2, Bax, Caspase3, Kir6.1, and p-JNK

Influence of sevoflurane or propofol anaesthesia on oxidative stress parameters in dogs with early-stage myxomatous mitral valve degeneration. A preliminary study

Trace elements and septic shock in elderly patients

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