Addition of lidocaine to levobupivacaine reduces intrathecal block duration: randomized controlled trial

Yazicioglu, Dilek; Akkaya, Taylan; Sonmez, Ercan; Gümüş, Haluk

doi:10.1016/j.bjane.2013.06.004

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Addition of lidocaine to levobupivacaine reduces intralethal block duration [4]. Tibial nerve block it is also very useful using the ultrasound-guided inframalleolar medial plantar nerve perineural injection [5].…”

Section: Discussionmentioning

confidence: 99%

Rib fractures and nerve block. A 84 case study

Metaxas¹,

Stamatatos²,

Bouchra³

et al. 2019

Open J Trauma

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The aim of the study is to determine the importance of nerve block in rib fracture patients. Methods:During the period January 2017-December 2018 a retrospective study took place. Eighty four patients diagnosed already with rib fractures underwent nerve bock by thoracic surgery department at General Hospital of Nicaea-Piraeus, Greece.Results: All 84 patients received nerve block and 54 of them received nerve block and Diclofenac injection. After a week of post nerve block along with regularly analgesic-NSAID medication the recorded pain has been reduced to minimum. Conclusion:Nerve block seems that is very helpful to reduce pain post rib fractures. Provides satisfactory pain relief and low cost. It can combine with analgesic and ant infl ammatory medication. Reduces patients hospital stay and even more suggested admission.

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Section: Discussionmentioning

confidence: 99%

Rib fractures and nerve block. A 84 case study

Metaxas¹,

Stamatatos²,

Bouchra³

et al. 2019

Open J Trauma

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show abstract

“…Therefore, to assess whether an analgesic-containing microparticle system is able to effectively relieve bone fracture pain, we used electrospraying technology to develop biodegradable levobupivacaine/ lidocaine/acemetacin-containing PLGA microcarriers. Previous studies reported that the use of multi-analgesics exhibit superior outcomes than the use of single drugs in pain relief [34][35][36]. While lidocaine and levobupivacaine are fast and short-term anesthesia, acemetacin belongs to long-duration NSAIDs.…”

Section: Introductionmentioning

confidence: 99%

Sustained Release of Levobupivacaine, Lidocaine, and Acemetacin from Electrosprayed Microparticles: In Vitro and In Vivo Studies

Chen

Liu

Yeh

et al. 2020

IJMS

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In this study, we explored the release characteristics of analgesics, namely levobupivacaine, lidocaine, and acemetacin, from electrosprayed poly(D,L-lactide-co-glycolide) (PLGA) microparticles. The drug-loaded particles were prepared using electrospraying techniques and evaluated for their morphology, drug release kinetics, and pain relief activity. The morphology of the produced microparticles elucidated by scanning electron microscopy revealed that the optimal parameters for electrospraying were 9 kV, 1 mL/h, and 10 cm for voltage, flow rate, and travel distance, respectively. Fourier-transform infrared spectrometry indicated that the analgesics had been successfully incorporated into the PLGA microparticles. The analgesic-loaded microparticles possessed low toxicity against human fibroblasts and were able to sustainably elute levobupivacaine, lidocaine, and acemetacin in vitro. Furthermore, electrosprayed microparticles were found to release high levels of lidocaine and acemetacin (well over the minimum therapeutic concentrations) and levobupivacaine at the fracture site of rats for more than 28 days and 12 days, respectively. Analgesic-loaded microparticles demonstrated their effectiveness and sustained performance for pain relief in fracture injuries.

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Addition of lidocaine to levobupivacaine reduces intrathecal block duration: randomized controlled trial

Abstract: Addition of low dose lidocaine to hyperbaric levobupivacaine reduces the duration of the intrathecal block provided by hyperbaric levobupivacaine. This technique can be used to reduce the spinal block duration for relatively short procedures like TUR-P.

Cited by 2 publications

References 14 publications

Rib fractures and nerve block. A 84 case study

Rib fractures and nerve block. A 84 case study

Sustained Release of Levobupivacaine, Lidocaine, and Acemetacin from Electrosprayed Microparticles: In Vitro and In Vivo Studies

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