Vitamin D and juvenile systemic lupus erythematosus: Lights, shadows and still unresolved issues

Stagi, Stefano; Rigante, Donato

doi:10.1016/j.autrev.2018.01.004

Cited by 14 publications

(5 citation statements)

References 156 publications

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“…Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease that mostly appears in young women. Studies described that SLE is associated with low vitamin D levels in disease expression, relapses, and pathogenesis [ 214 , 283 , 284 , 285 , 286 , 287 , 288 , 289 , 290 , 291 , 292 ]. In SLE, there is no association between vitamin D and pro-inflammatory cytokines.…”

Section: Vitamin D and Immune-related And Autoimmune Diseasesmentioning

confidence: 99%

An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases

Simu

Rednic

Grama

et al. 2022

IJMS

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Vitamin D intervenes in calcium and phosphate metabolism and bone homeostasis. Experimental studies have shown that 1,25-dihydroxyvitamin D (calcitriol) generates immunologic activities on the innate and adaptive immune system and endothelial membrane stability. Low levels of serum 25-hydroxyvitamin D (25(OH)D) are associated with an increased risk of developing immune-related diseases such as psoriasis, type 1 diabetes, multiple sclerosis, and autoimmune diseases. Various clinical trials describe the efficacy of supplementation of vitamin D and its metabolites for treating these diseases that result in variable outcomes. Different disease outcomes are observed in treatment with vitamin D as high inter-individual difference is present with complex gene expression in human peripheral blood mononuclear cells. However, it is still not fully known what level of serum 25(OH)D is needed. The current recommendation is to increase vitamin D intake and have enough sunlight exposure to have serum 25(OH)D at a level of 30 ng/mL (75 nmol/L) and better at 40–60 ng/mL (100–150 nmol/L) to obtain the optimal health benefits of vitamin D.

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Section: Vitamin D and Immune-related And Autoimmune Diseasesmentioning

confidence: 99%

An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases

Simu

Rednic

Grama

et al. 2022

IJMS

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“…Genome-wide association studies have provided deeper insights into the genetic causes of autoimmune diseases (8). Additionally, some environmental factors are important risk factors of autoimmune diseases, such as vitamin D deficiency and infections (6, 9–11). Recent epigenetic studies have further proven the essential role of epigenetics in the pathogeneses of autoimmune diseases (12–14).…”

Section: Introductionmentioning

confidence: 99%

Aberrant Expressions of Co-stimulatory and Co-inhibitory Molecules in Autoimmune Diseases

Wang

et al. 2019

Front. Immunol.

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Co-signaling molecules include co-stimulatory and co-inhibitory molecules and play important roles in modulating immune responses. The roles of co-signaling molecules in autoimmune diseases have not been clearly defined. We assessed the expressions of co-stimulatory and co-inhibitory molecules in autoimmune diseases through a bioinformatics-based study. By using datasets of whole-genome transcriptome, the expressions of 54 co-stimulatory or co-inhibitory genes in common autoimmune diseases were analyzed using Robust rank aggregation (RRA) method. Nineteen array datasets and 6 RNA-seq datasets were included in the RRA discovery study and RRA validation study, respectively. Significant genes were further validated in several autoimmune diseases including Graves' disease (GD). RRA discovery study suggested that CD160 was the most significant gene aberrantly expressed in autoimmune diseases (Adjusted P = 5.9E-12), followed by CD58 (Adjusted P = 5.7E-06) and CD244 (Adjusted P = 9.5E-05). RRA validation study also identified CD160 as the most significant gene aberrantly expressed in autoimmune diseases (Adjusted P = 5.9E-09). We further found that the aberrant expression of CD160 was statistically significant in multiple autoimmune diseases including GD ( P < 0.05), and CD160 had a moderate role in diagnosing those autoimmune diseases. Flow cytometry confirmed that CD160 was differentially expressed on the surface of CD8 + T cells between GD patients and healthy controls ( P = 0.002), which proved the aberrant expression of CD160 in GD at the protein level. This study suggests that CD160 is the most significant co-signaling gene aberrantly expressed in autoimmune diseases. Treatment strategy targeting CD160-related pathway may be promising for the therapy of autoimmune diseases.

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“…Many studies over the years have evaluated the significance of vitamin D deficiency in SLE [ 26 , 91 , 93 , 133 , 134 , 135 , 136 , 137 , 138 , 139 ]. Various studies performed in countries all over the world have shown that vitamin D deficiency is observed in patients with SLE [ 26 , 93 ].…”

Section: Systemic Lupus Erythematosus and Vitamin Dmentioning

confidence: 99%

Vitamin D and Autoimmune Rheumatic Diseases

Athanassiou

Kostoglou-Athanassiou

Koutsilieris

et al. 2023

Biomolecules

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Vitamin D is a steroid hormone with potent immune-modulating properties. It has been shown to stimulate innate immunity and induce immune tolerance. Extensive research efforts have shown that vitamin D deficiency may be related to the development of autoimmune diseases. Vitamin D deficiency has been observed in patients with rheumatoid arthritis (RA) and has been shown to be inversely related to disease activity. Moreover, vitamin D deficiency may be implicated in the pathogenesis of the disease. Vitamin D deficiency has also been observed in patients with systemic lupus erythematosus (SLE). It has been found to be inversely related to disease activity and renal involvement. In addition, vitamin D receptor polymorphisms have been studied in SLE. Vitamin D levels have been studied in patients with Sjogren’s syndrome, and vitamin D deficiency may be related to neuropathy and the development of lymphoma in the context of Sjogren’s syndrome. Vitamin D deficiency has been observed in ankylosing spondylitis, psoriatic arthritis (PsA), and idiopathic inflammatory myopathies. Vitamin D deficiency has also been observed in systemic sclerosis. Vitamin D deficiency may be implicated in the pathogenesis of autoimmunity, and it may be administered to prevent autoimmune disease and reduce pain in the context of autoimmune rheumatic disorders.

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Vitamin D and juvenile systemic lupus erythematosus: Lights, shadows and still unresolved issues

Cited by 14 publications

References 156 publications

An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases

An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases

Aberrant Expressions of Co-stimulatory and Co-inhibitory Molecules in Autoimmune Diseases

Vitamin D and Autoimmune Rheumatic Diseases

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